Summary & Overview

HCPCS Level II S9339: Home Peritoneal Dialysis Therapy, Per Diem

Headline: HCPCS Level II code S9339 covers comprehensive home peritoneal dialysis support

Lead: HCPCS Level II code S9339 designates a per diem home therapy service for peritoneal dialysis that bundles administrative and professional pharmacy services, care coordination, and necessary supplies and equipment, with drugs and nursing visits billed separately.

What this code represents and why it matters nationally HCPCS Level II code S9339 identifies an integrated per-diem payment for non-pharmacologic and non-nursing elements of home peritoneal dialysis care. As home-based dialysis grows, clear coding for administrative and coordination services is important for billing consistency, care continuity, and aligning payer coverage across the health system.

Key payers covered Major national payers considered include Aetna, Blue Cross Blue Shield, Cigna Health, and UnitedHealthcare.

Overview of what readers will learn This publication provides a concise overview of the clinical and billing context for S9339, how it relates to other home infusion and dialysis service codes, typical sites of service, and common operational considerations for per-diem home therapy codes. Readers will find benchmarks for service classification, payer coverage scope, and the clinical setting in which S9339 is applied.

Scope and limitations The summary focuses on national coding and payer context. Specific state-level policies and provider guidance are outside the scope. Data not available in the input for service line details.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareS9339HCPCS Level IIperitoneal dialysishome infusion therapyper diemcare coordinationprofessional pharmacy serviceshome dialysis suppliesbilling

Billing Code Overview

HCPCS Level II code S9339 describes home therapy for peritoneal dialysis provided on a per diem basis. The code encompasses administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment required to support peritoneal dialysis in the home setting. Drugs and nursing visits associated with peritoneal dialysis are coded separately.

Service Type: Home infusion therapy / peritoneal dialysis services

Typical Site of Service: Home (per diem service)

Data not available in the input for additional service line metadata.

Clinical & Coding Specifications

Clinical Context

A 68-year-old patient with end-stage renal disease performs daily peritoneal dialysis at home. The home infusion therapy pharmacy coordinates delivery of dialysis solution, supplies and equipment; provides administrative services, professional pharmacy oversight, care coordination, and arranges nursing visits as needed. A visiting nurse or home health aide troubleshoots exchanges, documents therapy, and communicates with the nephrology team. Billing uses HCPCS Level II code S9339 as a per diem for these combined administrative and professional services while medications and nursing visits are billed separately.

Coding Specifications

Modifier 59 — Distinct Procedural Service
Use when a service or procedure that is separate and distinct from other services performed on the same day needs to be identified; applies when documentation supports a separate service in addition to the per diem home therapy administrative services billed with HCPCS Level II code S9339.
Modifier 76 — Repeat Procedure by Same Physician
Use when a procedure or service is repeated subsequent to the original procedure by the same provider; applies if the per diem service represented by HCPCS Level II code S9339 is billed again for a repeat session or date of service requiring distinction from a prior same-day or prior-date billing by the same provider.

National Reimbursement Benchmarks

National mean rates for HCPCS Level II code S9339 show a substantial gap between Medicare-equivalent benchmarking and commercial aggregates, with BUCA (average commercial) mean ($110,205.28) far above Medicare (no national Medicare mean provided; Medicare data not available in the input). The BUCA mean is orders of magnitude higher than available commercial payers like Aetna ($17.77), Cigna Health ($121.28), and UnitedHealthcare ($87.13); Blue Cross Blue Shield reports an unusually large mean ($309,708.43).

Rate dispersion (P75 − P25) varies widely across payers. Blue Cross Blue Shield and BUCA show wide nominal spreads ($89.00 and $21.25, respectively, computed from provided percentiles), indicating greater variability. Aetna and UnitedHealthcare display tighter distributions (Aetna P75−P25 = 5.67; UnitedHealthcare P75−P25 = 0.00), while Cigna Health has a moderate spread ($21.00). The table and chart below present the full breakdown.

National Mean Rates for HCPCS Level II code `S9339` by Payer

Taxonomy Code	Specialty
`251J00000X`	Home Infusion Therapy Pharmacy
`163WH0200X`	Home Health Aide
`207Q00000X`	Family Medicine Physician

Related Diagnoses

Z79.899 — Other long term (current) drug therapy
Relevant when a patient is on chronic medication regimens associated with home infusion or dialysis support; documents long-term therapy status that may necessitate coordination of supplies and pharmacy services billed under HCPCS Level II code S9339.
Z51.81 — Encounter for therapeutic drug level monitoring
Relevant when laboratory monitoring of drug levels (for example, antibiotics or immunosuppressants) is required as part of home infusion or dialysis care coordination billed with HCPCS Level II code S9339.
T80.219A — Unspecified infection due to central venous catheter, initial encounter
Relevant when catheter-related infection requires additional home care coordination, supplies, or pharmacy interventions associated with services billed under HCPCS Level II code S9339.
Z45.2 — Encounter for adjustment and management of vascular access device
Relevant for ongoing management of vascular or access devices that are part of home therapy; care coordination and administrative services for these devices are encompassed by HCPCS Level II code S9339.
Z79.4 — Long term (current) use of insulin
Relevant when insulin-dependent patients receive coordinated home therapy services or pharmacy oversight alongside peritoneal dialysis support billed with HCPCS Level II code S9339.

Code	Description	Relationship to `S9339`
`99601`	Home infusion/specialty drug administration, per visit	Provides per-visit drug administration services that may be billed in addition to the per diem administrative/professional services of HCPCS Level II code `S9339` when a separate drug administration visit occurs.
`99602`	Home infusion/specialty drug administration, each additional hour	Billed for additional time during a home infusion administration visit; complements `99601` when extended administration time occurs alongside services covered by HCPCS Level II code `S9339`.
`S9379`	Home infusion therapy, hydration therapy; per diem	Alternative per diem HCPCS Level II code for hydration therapy; may be used instead of HCPCS Level II code `S9339` when the primary service is hydration rather than peritoneal dialysis administrative/professional services.
`S9345`	Home infusion therapy, anti-infective therapy; per diem	Alternative per diem HCPCS Level II code for anti-infective therapy; may be used instead of HCPCS Level II code `S9339` when the primary service is anti-infective home infusion rather than peritoneal dialysis administrative/professional services.

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Summary & Overview

HCPCS Level II S9339: Home Peritoneal Dialysis Therapy, Per Diem

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

National Reimbursement Benchmarks

Related Codes

Related Diagnoses

Related Codes

National Reimbursement Benchmarks

Related Codes