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    v1.0.28
    OpenPayerBilling CodesHemolytic anemiasICD-10-CM d59-acquired-hemolytic-anemia
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    ICD-10-CM Code For Acquired Hemolytic Anemia: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D59 includes acquired hemolytic anemias such as autoimmune hemolytic anemia, drug-induced hemolysis, and other nonhereditary hemolytic processes that cause premature red blood cell destruction. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving hemolysis with features such as anemia severity, immune or toxic etiology, and organ involvement like splenic enlargement or jaundice. Accurate coding within the ICD-10-CM D59 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

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    ICD-10-CM D59: Acquired Hemolytic Anemia Overview

    The acquired hemolytic anemias in this group represent disorders in which red blood cells are destroyed prematurely due to immune, toxic, or mechanical causes. These conditions affect the hematologic system and can lead to anemia, jaundice, and variable organ involvement such as the spleen. Accurate coding matters for appropriate clinical documentation and reimbursement because it captures the underlying cause, severity, and any associated complications that affect case complexity and payment.

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    When to Use

    Use a code from this group when clinical documentation indicates nonhereditary hemolysis with identified or suspected causes such as autoimmune reaction, drug toxicity, or mechanical hemolysis. Select the code that best captures the documented etiology, severity, and any associated complications noted in the medical record.

    ICD-10-CM Codes

    16 rows

    ICD-10-CM CodeDescription
    D59.0Drug-induced autoimmune hemolytic anemia
    D59.10Autoimmune hemolytic anemia, unspecified
    D59.11Warm autoimmune hemolytic anemia
    D59.12Cold autoimmune hemolytic anemia
    D59.13Mixed type autoimmune hemolytic anemia
    D59.19Other autoimmune hemolytic anemia
    D59.2Drug-induced nonautoimmune hemolytic anemia
    D59.30Hemolytic-uremic syndrome, unspecified
    D59.31Infection-associated hemolytic-uremic syndrome
    D59.32Hereditary hemolytic-uremic syndrome
    D59.39Other hemolytic-uremic syndrome
    D59.4Other nonautoimmune hemolytic anemias
    D59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
    D59.6Hemoglobinuria due to hemolysis from other external causes
    D59.8Other acquired hemolytic anemias
    D59.9Acquired hemolytic anemia, unspecified

    DRG Codes

    7 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    808Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC
    809Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC
    810Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC
    811Red Blood Cell Disorders with MCC
    812Red Blood Cell Disorders without MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with sudden onset jaundice, dark urine, tachycardia, and pallor after recently starting a new antibiotic; laboratory testing shows a falling hemoglobin, elevated indirect bilirubin, high lactate dehydrogenase, and a positive direct antiglobulin (Coombs) test consistent with immune-mediated red cell destruction. This acute hemolytic process is the reason for urgent evaluation and transfusion planning, and an acquired autoimmune hemolytic anemia code is assigned. Typical codes: D59.0, D59.11
    • A middle-aged patient with a history of systemic lupus erythematosus is seen in outpatient rheumatology for chronic anemia with recurrent low hemoglobin, reticulocytosis, and intermittent positive direct antiglobulin tests despite ongoing immunosuppressive therapy; management focuses on disease-modifying therapy adjustments and monitoring for hemolysis-related complications. Because the anemia is acquired and immune-related in the context of chronic autoimmune disease, a chronic hemolytic anemia code from this group is used. Typical codes: D59.11, D59.19
    • A hospitalized patient receiving multiple transfusions for trauma develops fever and hemoglobin drop with hemoglobinuria and laboratory evidence of hemolysis due to delayed hemolytic transfusion reaction; the event complicates the inpatient course and requires transfusion support and identification of alloantibodies. An acquired hemolytic anemia code specific to transfusion reaction or alloimmune hemolysis is assigned to capture this complication. Typical codes: D59.2, D59.12

    Related Codes

    D55-ANEMIA-DUE-TO-ENZYME-DISORDERS

    ICD-10-CM Code For Anemia Due To Enzyme Disorders: Group Overview

    D56-THALASSEMIA

    ICD-10-CM Code For Thalassemia: Group Overview

    D57-SICKLE-CELL-DISORDERS

    ICD-10-CM Code For Sickle-Cell Disorders: Group Overview

    D58-OTHER-HEREDITARY-HEMOLYTIC-ANEMIAS

    ICD-10-CM Code For Other Hereditary Hemolytic Anemias: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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