Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.28
    OpenPayerBilling CodesHemolytic anemiasICD-10-CM d57-sickle-cell-disorders
    Ask Trek AI about this page

    ICD-10-CM Code For Sickle-Cell Disorders: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D57 includes sickle-cell disorders such as sickle-cell disease with various complications, sickle-cell trait, and other specified and unspecified sickling disorders that affect hemoglobin structure and red blood cell function. These ICD-10-CM diagnosis codes are used to document clinical scenarios including acute vaso-occlusive pain crises, chronic hemolytic anemia, organ-specific complications like acute chest syndrome or stroke, and disease severity or complication status. Accurate coding within the ICD-10-CM D57 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

    Customize your policy alerts

    Sign up for ICD-10-CM Code For Sickle-Cell Disorders: Group Overview policy alerts

    Get alerted when relevant policies change without checking for updates manually.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    ICD-10-CM D57: Sickle-cell Disorders Overview

    The diagnoses in this group represent inherited hemoglobinopathies characterized by sickling of red blood cells leading to chronic hemolytic anemia and episodic vaso-occlusion. These conditions primarily affect the hematologic system but can cause multi-organ complications including pain crises, acute chest syndrome, stroke, and renal impairment. Accurate coding matters because it links documented clinical complexity to appropriate claim adjudication and reimbursement and supports continuity of care.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    When to Use

    Use codes from this group when documenting a patient with a confirmed diagnosis of a sickle-cell disorder, including presentations involving acute pain crises, hemolytic anemia, or specific organ complications. Select the most specific code that reflects the type of sickle-cell disease and any related manifestations to accurately represent clinical complexity.

    ICD-10-CM Codes

    43 rows

    ICD-10-CM CodeDescription
    D57.00Hb-SS disease with crisis, unspecified
    D57.01Hb-SS disease with acute chest syndrome
    D57.02Hb-SS disease with splenic sequestration
    D57.03Hb-SS disease with cerebral vascular involvement
    D57.04Hb-SS disease with dactylitis
    D57.09Hb-SS disease with crisis with other specified complication
    D57.1Sickle-cell disease without crisis
    D57.20Sickle-cell/Hb-C disease without crisis
    D57.211Sickle-cell/Hb-C disease with acute chest syndrome
    D57.212Sickle-cell/Hb-C disease with splenic sequestration
    D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
    D57.214Sickle-cell/Hb-C disease with dactylitis
    D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
    D57.219Sickle-cell/Hb-C disease with crisis, unspecified
    D57.3Sickle-cell trait
    D57.40Sickle-cell thalassemia without crisis
    D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
    D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
    D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
    D57.414Sickle-cell thalassemia, unspecified, with dactylitis

    Showing 1–20 of 43

    DRG Codes

    4 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    811Red Blood Cell Disorders with MCC
    812Red Blood Cell Disorders without MCC

    Typical Clinical Scenarios

    • An adolescent with known sickle cell disease presents to the emergency department with acute onset of severe generalized bone pain, fever, and tachycardia after a recent viral illness; labs show hemolytic anemia with elevated reticulocyte count and the patient requires opioid analgesia and intravenous fluids for a vaso-occlusive pain crisis. A diagnosis from this group is assigned to capture the acute painful vaso-occlusive episode in a patient with sickle cell disease. Typical codes: D57.0, D57.00, D57.01.

    • An adult with a lifelong history of sickle cell disease attends a routine hematology clinic for chronic management; they have persistent anemia with episodes of chronic hemolysis, multiple prior acute chest syndrome events, and are being evaluated for disease-modifying therapy. A current outpatient code from this group documenting the specific sickle cell genotype and chronic sickling without acute crisis is used to support ongoing care and coordination. Typical codes: D57.1, D57.20, D57.219.

    • A middle-aged patient with sickle cell disease is admitted for acute chest syndrome characterized by fever, new pulmonary infiltrate, hypoxia, and chest pain requiring supplemental oxygen and antibiotics; this represents an acute pulmonary complication of underlying sickling disease and is coded to reflect acute complication of sickle cell disorder. Typical codes: D57.0, D57.01, D57.418.

    Related Codes

    D55-ANEMIA-DUE-TO-ENZYME-DISORDERS

    ICD-10-CM Code For Anemia Due To Enzyme Disorders: Group Overview

    D56-THALASSEMIA

    ICD-10-CM Code For Thalassemia: Group Overview

    D58-OTHER-HEREDITARY-HEMOLYTIC-ANEMIAS

    ICD-10-CM Code For Other Hereditary Hemolytic Anemias: Group Overview

    D59-ACQUIRED-HEMOLYTIC-ANEMIA

    ICD-10-CM Code For Acquired Hemolytic Anemia: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.