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    OpenPayerBilling CodesHemolytic anemiasICD-10-CM d58-other-hereditary-hemolytic-anemias
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    ICD-10-CM Code For Other Hereditary Hemolytic Anemias: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D58 includes inherited hemolytic anemias other than sickle-cell and thalassemia, such as hereditary spherocytosis, elliptocytosis, and enzyme defects causing chronic hemolysis that result in anemia, jaundice, and splenomegaly. These ICD-10-CM diagnosis codes are used to document clinical presentations of chronic or episodic hemolysis, capture disease severity, organ involvement such as splenic or hepatic effects, and record complications like gallstones or iron overload. Accurate coding within the ICD-10-CM D58 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM D58: Other Hereditary Hemolytic Anemias Overview

    This group represents inherited disorders characterized by premature red blood cell destruction leading to anemia and related sequelae. These diagnoses target the hematologic system and may involve splenic enlargement, jaundice, and varying degrees of hemolysis. Accurate coding matters for reimbursement because it captures disease severity, need for interventions, and supports correct claim adjudication.

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    When to Use

    Use a code from this group when a patient has a documented hereditary hemolytic anemia confirmed by clinical findings and laboratory testing indicating chronic or recurrent hemolysis. Select codes to reflect the specific hereditary disorder and any associated complications such as splenomegaly or gallstones.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    D58.0Hereditary spherocytosis
    D58.1Hereditary elliptocytosis
    D58.2Other hemoglobinopathies
    D58.8Other specified hereditary hemolytic anemias
    D58.9Hereditary hemolytic anemia, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    811Red Blood Cell Disorders with MCC
    812Red Blood Cell Disorders without MCC

    Typical Clinical Scenarios

    • A 6-year-old child presents to the pediatric clinic with pallor, jaundice, and episodes of dark urine after minor infections; laboratory testing shows chronic hemolysis with elevated reticulocyte count, indirect bilirubin, and a family history of red blood cell enzyme deficiency. The clinician documents a chronic inherited hemolytic anemia due to a specific enzyme defect as the cause of ongoing hemolysis and schedules follow‑up for hemolytic monitoring and genetic counseling. Typical codes: D58.0, D58.9
    • An adult patient arrives to the emergency department with sudden onset fatigue, tachycardia, and marked scleral icterus after starting a new medication; labs confirm acute hemolytic anemia with hemoglobin drop and hemoglobinuria, and workup suggests a drug‑induced hemolysis in the setting of an underlying hereditary red cell vulnerability. The acute presentation prompts assignment of a code for an acute hemolytic event related to an inherited predisposition while treating the hemolysis and removing the offending agent. Typical codes: D58.1, D58.9
    • A middle‑aged patient with known congenital hemolytic anemia due to a structural red cell membrane defect is hospitalized for heart failure exacerbation and is noted to have chronic compensated hemolysis contributing to iron overload and transfusion dependence. The inherited hemolytic disorder is documented as a chronic comorbidity that affects inpatient management and transfusion planning. Typical codes: D58.2, D58.8

    Related Codes

    D55-ANEMIA-DUE-TO-ENZYME-DISORDERS

    ICD-10-CM Code For Anemia Due To Enzyme Disorders: Group Overview

    D56-THALASSEMIA

    ICD-10-CM Code For Thalassemia: Group Overview

    D57-SICKLE-CELL-DISORDERS

    ICD-10-CM Code For Sickle-Cell Disorders: Group Overview

    D59-ACQUIRED-HEMOLYTIC-ANEMIA

    ICD-10-CM Code For Acquired Hemolytic Anemia: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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