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    OpenPayerBilling CodesHemolytic anemiasICD-10-CM d56-thalassemia
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    ICD-10-CM Code For Thalassemia: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D56 includes inherited hemoglobin disorders such as alpha and beta thalassemia and related hemoglobinopathy variants that result in microcytic or hemolytic anemia and varying clinical severity. These ICD-10-CM diagnosis codes are used to document clinical scenarios including baseline disease type, transfusion dependence, complications such as iron overload or organ involvement, and disease severity. Accurate coding within the ICD-10-CM D56 group supports proper claim adjudication and complete clinical documentation and appropriate reimbursement.

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    ICD-10-CM D56: Thalassemia Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D56 covers inherited disorders of hemoglobin synthesis leading to chronic hemolytic anemia. These conditions primarily affect red blood cell production and oxygen transport and can involve multiple organ systems due to chronic anemia and iron overload. Accurate coding ensures complete clinical documentation and supports appropriate reimbursement for the complexity of care required.

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    When to Use

    Use a code from this group when documenting a confirmed diagnosis of thalassemia or a specific thalassemia subtype identified by clinical, laboratory, or genetic testing. Select codes that reflect disease severity, transfusion dependence, and any associated complications such as iron overload or organ dysfunction.

    ICD-10-CM Codes

    8 rows

    ICD-10-CM CodeDescription
    D56.0Alpha thalassemia
    D56.1Beta thalassemia
    D56.2Delta-beta thalassemia
    D56.3Thalassemia minor
    D56.4Hereditary persistence of fetal hemoglobin [HPFH]
    D56.5Hemoglobin E-beta thalassemia
    D56.8Other thalassemias
    D56.9Thalassemia, unspecified

    DRG Codes

    4 rows

    DRG CodeDescription
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    811Red Blood Cell Disorders with MCC
    812Red Blood Cell Disorders without MCC

    Typical Clinical Scenarios

    • An infant of Mediterranean descent presents to pediatric hematology with pallor, poor feeding, failure to thrive, and hepatosplenomegaly discovered on exam; laboratory testing shows microcytic hypochromic anemia with markedly reduced hemoglobin and electromorph patterns consistent with decreased beta-globin production. The child is diagnosed with a hereditary hemoglobinopathy causing chronic anemia requiring ongoing transfusion evaluation and genetic counseling, so a thalassemia diagnosis code is assigned. Typical codes: D56.1, D56.2
    • A 28-year-old pregnant woman with known beta thalassemia trait presents for routine prenatal care; she is asymptomatic but testing reveals mild, stable anemia attributed to her carrier state, and obstetric management is coordinated to monitor maternal hemoglobin and fetal well-being. Because the anemia is due to a documented thalassemia variant that affects pregnancy care but is not causing severe hemolysis, a thalassemia trait/code is used. Typical codes: D56.3, D56.9
    • A 45-year-old patient with longstanding transfusion-dependent thalassemia arrives at the emergency department with worsening shortness of breath and new-onset jaundice; evaluation reveals acute hemolytic exacerbation with elevated bilirubin and evidence of iron overload complications requiring urgent chelation therapy adjustment and supportive care. The acute hemolytic episode and chronic hemoglobinopathy are both relevant, so a thalassemia diagnosis reflecting chronic transfusion-dependent disease with acute hemolysis is assigned. Typical codes: D56.0, D56.8

    Related Codes

    D55-ANEMIA-DUE-TO-ENZYME-DISORDERS

    ICD-10-CM Code For Anemia Due To Enzyme Disorders: Group Overview

    D57-SICKLE-CELL-DISORDERS

    ICD-10-CM Code For Sickle-Cell Disorders: Group Overview

    D58-OTHER-HEREDITARY-HEMOLYTIC-ANEMIAS

    ICD-10-CM Code For Other Hereditary Hemolytic Anemias: Group Overview

    D59-ACQUIRED-HEMOLYTIC-ANEMIA

    ICD-10-CM Code For Acquired Hemolytic Anemia: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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