CPT code 90480 describes the administration of the first or only component of a SARS–CoV–2 (COVID–19) vaccine by intramuscular injection, a vaccine administration service typically performed in outpatient clinical settings such as physician offices, clinics, and vaccination sites to reduce a patient’s risk of contracting COVID–19; this CPT code represents the clinical act of giving the initial intramuscular COVID–19 vaccine dose and is used to document and bill that specific administration service.