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    v1.0.30
    OpenPayerBilling CodesImmunization Administration for Vaccines/ToxoidsCPT cpt-90472-additional-vaccine-injection
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    CPT 90472: Vaccine Injection, Subsequent Dose

    Medicare pays $17 on average nationally for this procedure.

    CPT code 90472 describes each subsequent vaccine injection administered after the first dose and is reported in addition to the code for the initial injection; this represents an injection administration service typically provided in outpatient clinic, physician office, or immunization clinic settings for per-dose vaccine delivery.

    For related coverage guidance, see recent payer policy updates: Abortion Services, Prolonged Services for Labor Management, Prolonged Services for Labor Management.

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    Clinical & Coding Specifications

    Clinical Context

    A patient presents to a primary care clinic for a scheduled multi-dose immunization series. After administration of the first vaccine dose (reported with the appropriate initial-dose CPT), the patient returns for the second injection of the same vaccine. The clinical workflow includes patient identity verification, review of vaccine history and contraindications, obtaining informed consent, preparation of the appropriate vaccine and syringe, administration of the intramuscular or subcutaneous injection, observation for immediate adverse reactions, and documentation in the medical record and immunization registry. Billing is submitted with the initial vaccine CPT for the first injection and with 90472 for each additional injection given during the same encounter or separate return visits, per payer rules. Typical sites of service are ambulatory clinics, physician offices, community health centers, and public health vaccination events. The typical patient scenario is an adult or pediatric patient receiving a multi-dose vaccine series (for example, a second dose of a COVID-19 vaccine, tetanus-containing vaccine series, or hepatitis B series) where each additional injection after the first is reported with 90472.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    90471Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular) for the first vaccine/toxoid component; first or only component of each vaccine administeredReports the first injection of a vaccine; 90472 is appended for each additional injection after 90471.
    90473Immunization administration by intranasal or oral route; first or only componentAlternative route-first dose reporting when vaccine is oral or intranasal; additional doses use corresponding additional-dose codes if available.
    90474Immunization administration by intranasal or oral route; each additional componentUsed to report additional oral/intranasal vaccine components after the first, analogous to 90472 for injectable vaccines.
    90702Diphtheria, tetanus toxoids, and acellular pertussis (DTaP) vaccineAn example vaccine CPT often reported with 90471 for dose one and 90472 for subsequent doses in the same series.
    90707Measles, mumps, and rubella (MMR) vaccineA vaccine CPT commonly administered in multi-dose schedules where 90472 may be used for additional injections.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207ZC0006X
    3416L0300X
    251T00000X
    2083A0100X
    363LN0000X
    2279P3900X
    132700000X
    207SG0203X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B34.2Coronavirus infection, unspecified
    B34.9Viral infection, unspecified
    B97.89Other viral agents as the cause of diseases classified elsewhere
    D70.9Neutropenia, unspecified
    J00Acute nasopharyngitis [common cold]
    J02.9Acute pharyngitis, unspecified
    J06.9Acute upper respiratory infection, unspecified
    J10.1Influenza due to other identified influenza virus with other respiratory manifestations
    J11.1Influenza due to unidentified influenza virus with other respiratory manifestations
    J18.9Pneumonia, unspecified organism

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Obstetrics/Gynecology1 / 3

    10 rows

    PolicyPayerEffective Date
    Abortion ServicesNew Mexico Health Care Authority2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesBlue Cross Blue Shield - Massachusetts2026-10-01
    Cervical Cancer ScreeningOscar Health2026-10-01
    Prenatal Testing for Fetal AneuploidyOscar Health2026-10-01
    Diagnosis of VaginitisOscar Health2026-10-01
    Prenatal Screening (Nongenetic)Oscar Health2026-10-01

    Related Codes

    CPT-90460-SINGLE-LIVE-ATTENUATED-VACCINE-ADMINISTRATION-PEDIATRIC

    CPT 90460: Administration of Single Live Attenuated Vaccine, ≤18 Years

    CPT-90461-ADDITIONAL-LIVE-ATTENUATED-VACCINE-ADMINISTRATION-PEDIATRICS

    CPT 90461: Additional Live Attenuated Vaccine Administration, Pediatrics

    CPT-90471-LIVE-ATTENUATED-VACCINE-ADMINISTRATION

    CPT 90471: Live Attenuated Vaccine Administration

    CPT-90473-LIVE-ATTENUATED-INTRANASAL-OR-ORAL-VACCINE-ADMINISTRATION

    CPT 90473: Live Attenuated Intranasal or Oral Vaccine Administration

    CPT-90474-ADDITIONAL-LIVE-ATTENUATED-VACCINE-ORAL-INTRANASAL-ADMINISTRATION

    CPT 90474: Additional Live Attenuated Vaccine, Oral or Intranasal

    CPT-90480-COVID19-VACCINE-IM-INJECTION-FIRST-DOSE

    CPT 90480: COVID-19 Vaccine, First or Only Intramuscular Dose

    CPT-90481-MULTICOMPONENT-COVID19-VACCINE-INTRAMUSCULAR-ADD-ON

    CPT 90481: Multicomponent SARS–CoV–2 Vaccine Administration, Intramuscular

    CPT-90482-IMMUNIZATION-COUNSELING-NO-VACCINE-ADMINISTERED

    CPT 90482: Immunization Counseling, 3–10 Minutes

    CPT-90483-IMMUNIZATION-COUNSELING-NO-ADMINISTRATION-10-20-MIN

    CPT 90483: Immunization Counseling, 10–20 Minutes

    CPT-90484-IMMUNIZATION-COUNSELING-NO-VACCINE-ADMINISTERED

    CPT 90484: Immunization Counseling >20 Minutes

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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