CPT 87624: HPV High-Risk Nucleic Acid Detection, Pooled

CPT code 87624 describes a laboratory molecular test that detects high-risk human papillomavirus (HPV) types using nucleic acid detection with a pooled result; service type: diagnostic molecular pathology test for HPV; typical site of service: clinical laboratory or hospital laboratory performing nucleic acid amplification testing.

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CPT 87624: HPV High-Risk Nucleic Acid Detection, Pooled

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Sign up for cpt 87624 policy alerts

Get alerted when payer policies referencing 87624 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A 32-year-old cisgender woman presents to her primary care clinic for routine cervical cancer screening. During the visit, the clinician performs a speculum exam and collects a cervical or vaginal specimen for human papillomavirus (HPV) testing using a liquid-based cytology or swab collection method. The specimen is sent to the laboratory where a molecular nucleic acid amplification test for pooled high-risk HPV types is performed by a laboratory technologist. Results return as positive or negative for high-risk HPV DNA; positive results prompt follow-up according to established screening guidelines, including reflex cytology or referral to colposcopy depending on age, prior testing, and clinical history. Typical sites of service include outpatient primary care clinics, obstetrics and gynecology offices, sexual health clinics, and hospital outpatient laboratory collection areas.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`88142`	Cytopathology, cervical or vaginal (Pap) smears by automated system; screening only	Performed concurrently when liquid-based cytology is ordered with HPV testing; may be the cytology component of reflex testing.
`88174`	Cytopathology, cervical or vaginal thin layer preparation; screening by automated system	Alternate cytology method often performed on the same specimen when co-testing with HPV.
`87625`	Infectious agent detection by nucleic acid (e.g., PCR), HPV, types 16 and 18 only; singleplex or multiplex	Related HPV molecular test specific for HPV-16 and -18 genotyping used when genotype-specific results are needed.
`87621`	Infectious agent detection by nucleic acid (e.g., PCR), HPV; high-risk types, each type	Genotype-specific HPV testing that may be ordered when individual type identification is required beyond pooled high-risk result.
`57454`	Colposcopy of the cervix including upper/adjacent vagina; with biopsy(s) of the cervix	Performed as follow-up when high-risk HPV is positive with abnormal cytology or per guidelines.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
261QP2400X	Prison Health Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
103TS0200X	School Psychologist	A psychologist whose specialty is concerned with the science and practice of psychology with children, youth, families; learners of all ages; and the …
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
224Y00000X	Clinical Exercise Physiologist	A Clinical Exercise Physiologist is a health care professional who is trained to work with patients with chronic disease where exercise training has b…
372500000X	Chore Provider	An individual who provides home maintenance services required to sustain a safe, sanitary living environment for individuals who because of age or dis…

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
A63.0	Anogenital (venereal) warts
B97.7	Papillomavirus as the cause of diseases classified elsewhere
C53.0	Malignant neoplasm of endocervix
C53.1	Malignant neoplasm of exocervix
C53.9	Malignant neoplasm of cervix uteri, unspecified
D06.9	Carcinoma in situ of cervix, unspecified
N72	Inflammatory disease of cervix uteri
N76.0	Acute vaginitis
N76.1	Subacute and chronic vaginitis
N76.2	Acute vulvitis

Showing 1–10 of 27

Related Payer Policy Updates

Specialty: Infectious Disease1 / 3

10 rows

Policy	Payer	Effective Date
B-Hemolytic Streptococcus Testing	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays	Oscar Health	2026-10-01
Hepatitis Testing (A, B, C, D) Coverage Criteria	Oscar Health	2026-10-01
Pathogen Panel Testing	Oscar Health	2026-10-01
Lyme Disease Testing Coverage Criteria	Oscar Health	2026-10-01
Diagnostic Testing of Common Sexually Transmitted Infections	Oscar Health	2026-10-01
Testing for Diagnosis of Active or Latent Tuberculosis	Oscar Health	2026-10-01
Coronavirus Testing in the Outpatient Setting	Oscar Health	2026-10-01
Testing for Vector-Borne Infections	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV)	blue cross blue shield - louisiana	2026-09-15

CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87265: Bordetella Antigen Detection by Immunofluorescence

CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

CPT 87267: Enterovirus Antigen Detection by DFA

CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87269: Giardia Antigen Detection by Immunofluorescence

CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

CPT-87271-CMV-DFA-ANTIGEN-DETECTION

CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87275: Influenza B Antigen Detection by Immunofluorescence

Showing 1–10 of 167

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`88142`	Cytopathology, cervical or vaginal (Pap) smears by automated system; screening only	Performed concurrently when liquid-based cytology is ordered with HPV testing; may be the cytology component of reflex testing.
`88174`	Cytopathology, cervical or vaginal thin layer preparation; screening by automated system	Alternate cytology method often performed on the same specimen when co-testing with HPV.
`87625`	Infectious agent detection by nucleic acid (e.g., PCR), HPV, types 16 and 18 only; singleplex or multiplex	Related HPV molecular test specific for HPV-16 and -18 genotyping used when genotype-specific results are needed.
`87621`	Infectious agent detection by nucleic acid (e.g., PCR), HPV; high-risk types, each type	Genotype-specific HPV testing that may be ordered when individual type identification is required beyond pooled high-risk result.
`57454`	Colposcopy of the cervix including upper/adjacent vagina; with biopsy(s) of the cervix	Performed as follow-up when high-risk HPV is positive with abnormal cytology or per guidelines.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
261QP2400X	Prison Health Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
103TS0200X	School Psychologist	A psychologist whose specialty is concerned with the science and practice of psychology with children, youth, families; learners of all ages; and the …
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
224Y00000X	Clinical Exercise Physiologist	A Clinical Exercise Physiologist is a health care professional who is trained to work with patients with chronic disease where exercise training has b…
372500000X	Chore Provider	An individual who provides home maintenance services required to sustain a safe, sanitary living environment for individuals who because of age or dis…

Related ICD-10-CM Codes

27 rows

ICD-10-CM Code	Description
A63.0	Anogenital (venereal) warts
B97.7	Papillomavirus as the cause of diseases classified elsewhere
C53.0	Malignant neoplasm of endocervix
C53.1	Malignant neoplasm of exocervix
C53.9	Malignant neoplasm of cervix uteri, unspecified
D06.9	Carcinoma in situ of cervix, unspecified
N72	Inflammatory disease of cervix uteri
N76.0	Acute vaginitis
N76.1	Subacute and chronic vaginitis
N76.2	Acute vulvitis

Showing 1–10 of 27

Related Payer Policy Updates

Specialty: Infectious Disease1 / 3

10 rows

Policy	Payer	Effective Date
B-Hemolytic Streptococcus Testing	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays	Oscar Health	2026-10-01
Hepatitis Testing (A, B, C, D) Coverage Criteria	Oscar Health	2026-10-01
Pathogen Panel Testing	Oscar Health	2026-10-01
Lyme Disease Testing Coverage Criteria	Oscar Health	2026-10-01
Diagnostic Testing of Common Sexually Transmitted Infections	Oscar Health	2026-10-01
Testing for Diagnosis of Active or Latent Tuberculosis	Oscar Health	2026-10-01
Coronavirus Testing in the Outpatient Setting	Oscar Health	2026-10-01
Testing for Vector-Borne Infections	Oscar Health	2026-10-01
Human Immunodeficiency Virus (HIV)	blue cross blue shield - louisiana	2026-09-15

CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87265: Bordetella Antigen Detection by Immunofluorescence

CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

CPT 87267: Enterovirus Antigen Detection by DFA

CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87269: Giardia Antigen Detection by Immunofluorescence

CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

CPT-87271-CMV-DFA-ANTIGEN-DETECTION

CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

CPT 87275: Influenza B Antigen Detection by Immunofluorescence

Showing 1–10 of 167

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 87624: HPV High-Risk Nucleic Acid Detection, Pooled

Sign up for cpt 87624 policy alerts

OpenPayer

CPT 87624: HPV High-Risk Nucleic Acid Detection, Pooled

Sign up for cpt 87624 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

References

CPT 87624: HPV High-Risk Nucleic Acid Detection, Pooled

Sign up for cpt 87624 policy alerts

CPT 87624: HPV High-Risk Nucleic Acid Detection, Pooled

Sign up for cpt 87624 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

What does CPT 87624 represent and where is it typically performed?

Which modifiers are commonly used with CPT 87624 and when would they apply?

How does CPT 87624 relate to Pap cytology codes and other HPV molecular test codes?

In what clinical contexts is CPT 87624 used and what follows a positive result?

Which payers are included in the analysis and does the page provide reimbursement rates or detailed coverage policies?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

What does CPT 87624 represent and where is it typically performed?

Which modifiers are commonly used with CPT 87624 and when would they apply?

How does CPT 87624 relate to Pap cytology codes and other HPV molecular test codes?

In what clinical contexts is CPT 87624 used and what follows a positive result?

Which payers are included in the analysis and does the page provide reimbursement rates or detailed coverage policies?

References