CPT code 87274 covers laboratory detection of Herpes simplex virus type 1 (HSV-1) antigens using immunofluorescent antibody staining and fluorescence microscopy. This test is used in clinical microbiology laboratories to identify HSV-1 infection directly from patient specimens and can affect diagnosis, infection control, and antiviral treatment decisions. Nationally, antigen detection methods remain part of the diagnostic toolkit alongside viral culture and molecular assays, with use varying by clinical setting and laboratory capability.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for antigen-based HSV-1 testing, typical sites of service, and how CPT code 87274 fits into laboratory service lines. The publication summarizes common billing modifiers and payer coverage patterns where available, highlights benchmarking and reimbursement considerations, and provides policy and coding guidance relevant to laboratories and billing professionals. Data not available in the input is noted where applicable. This piece is intended for laboratory managers, billing specialists, and policy analysts seeking a national-level briefing on CPT code 87274 and its clinical billing context.