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    v1.0.28
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80434-insulin-tolerance-test-glucose-cortisol-serial-measurement
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    CPT 80434: Insulin Tolerance Test — Glucose and Cortisol Measurements

    CPT code 80434 describes laboratory analysis for an insulin tolerance test in which glucose and cortisol concentrations are measured in five serial blood samples (one pre-insulin and four post-insulin); service type: dynamic endocrine function testing; typical site of service: outpatient laboratory or hospital clinical laboratory during an endocrinology evaluation.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Bone Turnover Markers Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old patient with suspected hypoglycemia undergoes an insulin tolerance test to evaluate counter-regulatory hormone response and glucose homeostasis. The procedure is performed in an outpatient endocrinology clinic or hospital clinical laboratory under direct physician supervision. After informed consent, baseline blood is drawn for glucose and cortisol. Short-acting insulin is administered intravenously, and timed blood samples are collected: one pre-insulin and four post-insulin draws (commonly at 30, 45, 60 and 90 minutes) for measurement of serum glucose and cortisol. The lab analyst processes and measures glucose and cortisol levels for each of the five samples. The supervising endocrinologist monitors the patient for symptomatic hypoglycemia, documents vital signs and mental status at intervals, and provides corrective glucose as needed. Results are reviewed by the clinician to assess pituitary-adrenal axis integrity and counter-regulatory hormone response, guiding diagnosis and management of adrenal insufficiency, growth hormone deficiency, or disorders of glucose regulation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80434Insulin tolerance test; lab analysis measuring glucose and cortisol in five samples (one pre, four post)Primary code describing the laboratory measurement component as specified.
    82947Glucose; quantitative, blood (eg, glucose oxidase)Performed for individual glucose measurements if billed separately or by the performing laboratory.
    82533Assay of cortisol; totalPerformed for individual cortisol measurements if billed separately or by the performing laboratory.
    36415Collection of venous blood by venipuncturePerformed for each scheduled blood draw; billed when separate from the lab panel.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance)May be reported for the administration of intravenous insulin when reported separately from the laboratory analysis.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    363LF0000XFamily Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    2085N0904XNuclear Radiology PhysicianA radiologist who is involved in the analysis and imaging of radionuclides and radiolabeled substances in vitro and in vivo for diagnosis and the admi…
    207U00000XNuclear Medicine PhysicianA nuclear medicine specialist employs the properties of radioactive atoms and molecules in the diagnosis and treatment of disease and in research. Rad…
    207ZP0007XMolecular Genetic Pathology (Pathology) PhysicianA molecular genetic pathologist is expert in the principles, theory and technologies of molecular biology and molecular genetics. This expertise is us…
    246ZC0007XSurgical AssistantA surgical assistant is a skilled practitioner who has undergone formalized education and training as a surgical assistant. The surgical assistant per…
    207RI0008XHepatology PhysicianThe discipline of Hepatology encompasses the structure, function, and diseases of the liver and biliary tract. The American Board of Internal Medicine…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E08.65Diabetes mellitus due to underlying condition with hyperglycemia
    E08.9Diabetes mellitus due to underlying condition without complications
    E10.21Type 1 diabetes mellitus with diabetic nephropathy
    E10.40Type 1 diabetes mellitus with diabetic neuropathy, unspecified
    E10.65Type 1 diabetes mellitus with hyperglycemia
    E10.69Type 1 diabetes mellitus with other specified complication
    E10.9Type 1 diabetes mellitus without complications
    E11.21Type 2 diabetes mellitus with diabetic nephropathy
    E11.22Type 2 diabetes mellitus with diabetic chronic kidney disease

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    5 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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