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    v1.0.28
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80426-serial-fsh-lh-assay-four-samples
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    CPT 80426: Serial FSH and LH Measurement, Four-Timed Serum Samples

    CPT code 80426 reports laboratory measurement of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels from a total of four serum samples collected at four distinct times during a single procedure; the service is a serial hormone assay typically performed in a clinical laboratory or hospital laboratory setting for reproductive endocrinology or fertility evaluations.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Bone Turnover Markers Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a reproductive-age woman undergoing evaluation for suspected ovulatory dysfunction or infertility. The clinician orders a timed serum gonadotropin panel to obtain follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels measured from four blood draws collected at specified intervals (for example baseline and three subsequent time points) to evaluate pulsatility, surge pattern, or dynamic responses during an ovarian stimulation cycle or evaluation of hypothalamic-pituitary-ovarian axis function. The workflow: the patient presents to an outpatient phlebotomy clinic or fertility clinic on a scheduled procedure day; nursing places an intravenous or uses serial venipuncture to collect four serum samples at the prescribed time points; each sample is labeled and sent to the laboratory; the lab analyst performs immunoassays for FSH and LH on all four specimens and reports values to the ordering clinician, who interprets patterns in the context of menstrual history, medications, and other endocrine testing.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    83001Qualitative pregnancy test (e.g., serum, urine)Often performed before timed hormone panels to confirm nonpregnancy prior to ovarian stimulation or dynamic testing.
    84443Thyroid stimulating hormone (TSH)Frequently ordered in evaluation of menstrual irregularity and infertility as part of endocrine assessment alongside FSH/LH testing.
    85025Blood count; complete (CBC) automatedRoutine baseline laboratory screening performed in fertility workups or prior to procedures that may accompany timed sampling.
    83615Estradiol; direct (e.g., serum)Commonly measured concurrently with FSH and LH to evaluate follicular development and ovarian response.
    86152Follicle stimulating hormone (FSH)Individual FSH assay code used when single-point measurements are billed separately; related conceptually to the multi-sample panel represented by 80426.
    83655Luteinizing hormone (LH)Individual LH assay code used when single-point measurements are billed separately; related to the multi-sample series in 80426.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    310400000XAssisted Living FacilityA facility providing supportive services to individuals who can function independently in most areas of activity, but need assistance and/or monitorin…
    367500000XCertified Registered Nurse Anesthetist(1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, prov…
    225200000XPhysical Therapy Assistant(1)Physical therapist assistants are skilled health care providers who are graduates of a physical therapist assistant associate degree program accred…
    207SG0207XMedical Biochemical GeneticsA medical biochemical geneticist specializes in the diagnosis, evaluation, prevention, and treatment of patients with biochemical genetic disorders, d…
    170100000XPh.D. Medical GeneticsA medical geneticist works in association with a medical specialist, is affiliated with a clinical genetics program, and serves as a consultant to med…
    261QE0700XEnd-Stage Renal Disease (ESRD) Treatment Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    273Y00000XRehabilitation Hospital UnitIn general, a distinct unit of a general acute care hospital that provides care encompassing a comprehensive array of restoration services for the dis…

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    E23.0Hypopituitarism
    E23.1Drug-induced hypopituitarism
    E28.2Polycystic ovarian syndrome
    E28.8Other ovarian dysfunction
    E34.9Endocrine disorder, unspecified
    F52.22Female sexual arousal disorder
    N91.2Amenorrhea, unspecified
    N92.5Other specified irregular menstruation
    N92.6Irregular menstruation, unspecified
    N93.9Abnormal uterine and vaginal bleeding, unspecified

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    5 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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