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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Genitourinary SystemCPT cpt-78730-ureteral-reflux-and-bladder-function-radioisotope-study
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    CPT 78730: Ureteral Reflux Study with Bladder Functional Evaluation

    Medicare pays $51 on average nationally for this procedure.

    CPT code 78730 describes a procedure in which a radioisotope is administered during a ureteral reflux study to evaluate functional defects of the urinary bladder; service type: diagnostic nuclear medicine study combined with a voiding/urodynamic component; typical site of service: hospital outpatient department or ambulatory imaging center where nuclear medicine and fluoroscopic voiding studies are performed.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric patient with a history of recurrent febrile urinary tract infections is referred for evaluation of suspected vesicoureteral reflux and bladder dysfunction. The clinician performs a radionuclide cystogram with simultaneous ureteral reflux study using a radioisotope to detect reflux and to evaluate functional defects of the urinary bladder (such as post-void residual, bladder emptying dysfunction, or intravesical reflux). The procedure is typically scheduled in an outpatient radiology or nuclear medicine department, or in a hospital outpatient imaging suite. The workflow includes: pre-procedure consent and allergy screening, catheterization of the bladder, instillation of a tracer-labeled saline or radiopharmaceutical, acquisition of dynamic gamma camera imaging during filling and voiding phases, post-void imaging to assess residual activity, interpretation by a radiologist or nuclear medicine physician, and documentation of findings including presence/grade of reflux and any functional bladder abnormality. The patient may require supervision by pediatric nursing staff and may be discharged the same day with follow-up arranged with the referring pediatrician or pediatric urologist.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78740Intravenous renal scintigraphy; including an angioscintigraphic phase when performedMay be performed alongside to evaluate renal drainage and differential renal function when reflux is suspected.
    78750Diuretic renal scintigraphy (e.g., Lasix renal scan)Used when assessment of obstructive uropathy or drainage is needed in conjunction with bladder functional assessment.
    74400Fluoroscopic cystography, voiding (including voiding radiographs)Alternative or complementary study to evaluate vesicoureteral reflux with anatomic detail; may be performed instead of or after radionuclide study.
    51701Complex uroflowmetry with pressure flow studies including cystometrogram when performedPerformed by urology to evaluate bladder function and may follow radionuclide functional assessment.
    51798Bladder catheterization, single or multiplePerformed as part of study set-up to instill radiotracer into the bladder prior to imaging.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    246QL0901X
    207PE0004X
    101YS0200X
    213EP1101X
    133VN1201X
    207RG0100X
    2083C0008X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    N10Acute pyelonephritis
    N11.0Nonobstructive reflux-associated chronic pyelonephritis
    N11.1Chronic obstructive pyelonephritis
    N12Tubulo-interstitial nephritis, not specified as acute or chronic
    N13.6Pyonephrosis
    N20.0Calculus of kidney
    N20.1Calculus of ureter
    N20.2Calculus of kidney with calculus of ureter
    N28.9Disorder of kidney and ureter, unspecified
    N30.00Acute cystitis without hematuria

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Nephrology1 / 3

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-78700-KIDNEY-SCAN-NUCLEAR-MEDICINE-RENAL-FUNCTION

    CPT 78700: Kidney Scan (Cortical and Functional Renal Scintigraphy)

    CPT-78701-KIDNEY-SCAN-NUCLEAR-MEDICINE-KIDNEY-IMAGING

    CPT 78701: Kidney Nuclear Scan (Cortical and Functional)

    CPT-78707-KIDNEY-SCAN-NUCLEAR-MEDICINE

    CPT 78707: Kidney Scan (Renal Nuclear Medicine)

    CPT-78708-KIDNEY-SCAN-NUCLEAR-MEDICINE-RENAL-IMAGING

    CPT 78708: Kidney Scan (Renal Scintigraphy)

    CPT-78709-KIDNEY-SCAN-RENAL-NUCLEAR-IMAGING

    CPT 78709: Renal Nuclear Medicine Scan

    CPT-78725-KIDNEY-SCAN-NUCLEAR-MEDICINE-RENAL-IMAGING

    CPT 78725: Kidney Scan, Cortical and Functional

    CPT-78740-VOIDING-CYSTOURETHROGRAM-URETERAL-REFLUX-EVALUATION

    CPT 78740: Voiding Cystourethrogram to Evaluate Ureteral Reflux

    CPT-78761-NUCLEAR-MEDICINE-TESTICULAR-IMAGING-RADIOPHARMACEUTICAL

    CPT 78761: Scrotal Nuclear Medicine Scintigraphy for Acute Testicular Pain

    CPT-78799-DIAGNOSTIC-NUCLEAR-MEDICINE-GENITOURINARY

    CPT 78799: Diagnostic Nuclear Medicine Procedure, Genitourinary

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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