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    v1.0.30
    OpenPayerBilling CodesEndometrial sampling, D&C and Uterus Tumor Excision ProceduresCPT cpt-58110-endometrial-biopsy-with-colposcopy
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    CPT 58110: Endometrial Biopsy During Colposcopy

    Medicare pays $52 on average nationally for this procedure.

    CPT code 58110 describes an add-on procedure for performing an endometrial biopsy at the same session as a colposcopy, representing a gynecologic biopsy service performed during a diagnostic lower genital tract examination; service type: procedural/biopsy add-on; typical site of service: outpatient clinic or ambulatory surgical center concurrent with colposcopy.

    For related coverage guidance, see recent payer policy updates: Abortion Services, Prolonged Services for Labor Management, Prolonged Services for Labor Management.

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    Clinical & Coding Specifications

    Clinical Context

    A 36-year-old woman presents to a gynecology clinic with abnormal uterine bleeding and an abnormal cervical cytology result. The clinician performs a diagnostic colposcopy to evaluate the cervix and, during the same visit, obtains an endometrial biopsy to sample the uterine lining for pathology. The workflow includes patient consent, positioning in the speculum exam chair, application of acetic acid and Lugol's iodine to the cervix for colposcopic assessment, directed cervical biopsies if indicated, and then insertion of an endometrial sampling device (such as a Pipelle) to aspirate endometrial tissue. Specimens are placed in labeled containers and sent to histopathology. Procedure documentation includes indication, findings at colposcopy, details of the endometrial sample, anesthesia or analgesia used, any complications, and the use of modifier(s) as appropriate. Billing uses 58110 as the add-on code when endometrial biopsy is performed at the same session as colposcopy, reported in conjunction with the primary colposcopy procedure code.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    57454Colposcopy of the cervix including upper/adjacent vagina with biopsy(s) of the cervixPrimary colposcopy procedure commonly billed alongside 58110; colposcopy is the main service during which the add-on endometrial biopsy is performed
    57460Colposcopy of the cervix including upper/adjacent vagina; with loop electrode biopsy(s), with or without fulgurationAlternate colposcopy procedure that may precede or accompany endometrial biopsy when excisional cervical treatment is needed
    58300Endometrial sampling (by aspiration)Stand-alone endometrial sampling code; 58110 is an add-on when done in same session as colposcopy rather than billing 58300 separately
    57500Biopsy, single or multiple, of cervix, with or without endocervical curettageCervical biopsies commonly performed during colposcopy visit in addition to endometrial biopsy
    59025Fetal non-stress test (NST) or antepartum fetal testingNot routine for this procedure but may appear in obstetric patients undergoing evaluation when fetal monitoring is indicated

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207VG0400X
    207V00000X
    363LF0000X
    207K00000X
    225XR0403X
    2083T0002X
    207P00000X
    246ZB0500X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C53.9Malignant neoplasm of cervix uteri, unspecified
    C54.9Malignant neoplasm of corpus uteri, unspecified
    C55Malignant neoplasm of uterus, part unspecified
    N76.0Acute vaginitis
    N76.1Subacute and chronic vaginitis
    N76.2Acute vulvitis
    N80.9Endometriosis, unspecified
    N84.1Polyp of cervix uteri
    N86Erosion and ectropion of cervix uteri
    N87.0Mild cervical dysplasia

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Obstetrics/Gynecology1 / 2

    10 rows

    PolicyPayerEffective Date
    Abortion ServicesNew Mexico Health Care Authority2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Obstetrical Home Care ProgramsAmbetter Georgia2026-11-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesBlue Cross Blue Shield - Massachusetts2026-10-01
    Cervical Cancer ScreeningOscar Health2026-10-01
    Prenatal Testing for Fetal AneuploidyOscar Health2026-10-01
    Diagnosis of VaginitisOscar Health2026-10-01

    Related Codes

    CPT-58100-ENDOMETRIAL-BIOPSY-OFFICE-AMBULATORY

    CPT 58100: Endometrial biopsy without cervical dilation

    CPT-58120-ENDOMETRIAL-CURETTAGE-DILATION-AND-CURETTAGE

    CPT 58120: Dilation and Curettage for Uterine Bleeding

    CPT-58140-ABDOMINAL-MYOMECTOMY-1-TO-4-FIBROIDS-250G-OR-LESS

    CPT 58140: Myomectomy, Abdominal, 1–4 Fibroids ≤250 g

    CPT-58145-VAGINAL-MYOMECTOMY-UTERINE-FIBROID-EXCISION-1-TO-4-TUMORS

    CPT 58145: Vaginal Myomectomy, 1–4 Fibroids ≤250 g

    CPT-58146-ABDOMINAL-MYOMECTOMY-5-PLUS-FIBROIDS-GT-250G

    CPT 58146: Abdominal Myomectomy, 5+ Fibroids, Total >250 g

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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