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    OpenPayerBilling CodesEndometrial sampling, D&C and Uterus Tumor Excision ProceduresCPT cpt-58100-endometrial-biopsy-office-ambulatory
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    CPT 58100: Endometrial biopsy without cervical dilation

    Medicare pays $101 on average nationally for this procedure.

    CPT code 58100 describes an endometrial biopsy in which the provider obtains a tissue sample from the uterine lining without dilation of the cervix; an endocervical biopsy may also be performed. Service type: endometrial/endocervical biopsy. Typical site of service: office or ambulatory surgical center for diagnostic evaluation of uterine lining pathology.

    For related coverage guidance, see recent payer policy updates: Abortion Services, Prolonged Services for Labor Management, Prolonged Services for Labor Management.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 48-year-old woman presenting to a gynecology clinic with abnormal uterine bleeding, postmenopausal bleeding, or persistent intermenstrual spotting. After history, pelvic exam, and noninvasive testing (pregnancy test, pelvic ultrasound as indicated), the clinician recommends an outpatient endometrial biopsy to obtain tissue for histologic evaluation. The procedure is performed in an exam room or minor procedure suite: the patient is placed in lithotomy position, a speculum is inserted, the cervix is cleansed, and a single-operator endometrial biopsy instrument is passed through the cervical canal without mechanical dilation to sample the endometrial lining. Local anesthesia or paracervical block may be used for comfort. An endocervical curettage or biopsy may be obtained in the same encounter if indicated. Specimens are submitted to pathology for evaluation of hyperplasia, malignancy, or other endometrial pathology. The encounter typically includes pre-procedure counseling, consent, specimen collection, and brief post-procedure observation before discharge to home.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    76830Transvaginal ultrasound, limited or follow-upOften performed before biopsy to evaluate endometrial thickness and guide decision to biopsy.

    | 58110 | Endometrial sampling (dilatation and curettage), diagnostic | More invasive endometrial sampling performed when office biopsy is nondiagnostic or when dilation is required; alternative to 58100.

    | 57460 | Colposcopy of the cervix including upper/adjacent vagina | May be performed same day if abnormal cervical findings necessitate direct cervical evaluation; not routine with 58100 but related for cervical pathology.

    | 88172 | Cytopathology, immediate and direct smears, interpretation on-site | May be used if on-site adequacy assessment of specimen is performed during biopsy.

    | 88305 | Level IV surgical pathology, gross and microscopic examination | Common pathology charge for endometrial tissue specimens submitted after biopsy.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    24Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    208D00000X
    367A00000X
    3747P1801X
    291U00000X
    2084N0400X
    332BN1400X
    146M00000X

    Related Payer Policy Updates

    Specialty: Obstetrics/Gynecology1 / 2

    10 rows

    PolicyPayerEffective Date
    Abortion ServicesNew Mexico Health Care Authority2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Prolonged Services for Labor ManagementPremera Bluecross2027-01-01
    Obstetrical Home Care ProgramsAmbetter Georgia2026-11-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesPremera Bluecross2026-10-01
    Maternal Serum Testing for Prediction of Adverse Obstetric OutcomesBlue Cross Blue Shield - Massachusetts2026-10-01
    Cervical Cancer ScreeningOscar Health2026-10-01
    Prenatal Testing for Fetal AneuploidyOscar Health2026-10-01
    Diagnosis of VaginitisOscar Health2026-10-01

    Related Codes

    CPT-58110-ENDOMETRIAL-BIOPSY-WITH-COLPOSCOPY

    CPT 58110: Endometrial Biopsy During Colposcopy

    CPT-58120-ENDOMETRIAL-CURETTAGE-DILATION-AND-CURETTAGE

    CPT 58120: Dilation and Curettage for Uterine Bleeding

    CPT-58140-ABDOMINAL-MYOMECTOMY-1-TO-4-FIBROIDS-250G-OR-LESS

    CPT 58140: Myomectomy, Abdominal, 1–4 Fibroids ≤250 g

    CPT-58145-VAGINAL-MYOMECTOMY-UTERINE-FIBROID-EXCISION-1-TO-4-TUMORS

    CPT 58145: Vaginal Myomectomy, 1–4 Fibroids ≤250 g

    CPT-58146-ABDOMINAL-MYOMECTOMY-5-PLUS-FIBROIDS-GT-250G

    CPT 58146: Abdominal Myomectomy, 5+ Fibroids, Total >250 g

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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