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    OpenPayerBilling CodesExcision Procedures on the PenisCPT cpt-54135-radical-penectomy-bilateral-inguinal-lymphadenectomy
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    CPT 54135: Radical Penectomy with Inguinal Lymphadenectomy

    Medicare pays $1366 on average nationally for this procedure.

    CPT code 54135 describes a radical penectomy with bilateral or unilateral inguinal lymph node dissection, a surgical oncology procedure that completely removes the penis and the groin lymph nodes to treat advanced or extensive penile cancer; service type: major surgical oncology of the genitalia, typical site of service: inpatient hospital operating room with possible postoperative inpatient stay.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a male in his 50s–70s with a biopsy-proven, locally advanced squamous cell carcinoma of the penis that is refractory to local therapies or demonstrates extensive primary tumor involvement and regional nodal disease. The clinical workflow begins with multidisciplinary evaluation (urology, medical oncology, radiation oncology, and pathology), staging with physical exam and imaging (CT/MRI and possible PET), and discussion of risks, benefits, and alternatives. Preoperative optimization includes informed consent, review of comorbidities (cardiopulmonary status, anticoagulation management, diabetes control), and counseling regarding urinary diversion and reconstructive options. On the day of surgery the patient undergoes radical penectomy with bilateral inguinal lymphadenectomy under general anesthesia; intraoperative considerations include meticulous hemostasis, preservation or reconstruction of urethral length for perineal urethrostomy, and placement of drains. Postoperative care involves pain control, wound and flap monitoring, drain management, DVT prophylaxis, pathology review of margins and nodal status, and coordination of adjuvant therapy if indicated. Long-term follow-up addresses oncologic surveillance, psychosocial support, prosthetic or reconstruction referrals, and sexual and urinary function counseling.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54125Partial penectomy; excision of lesion with preservation of urethraPerformed for less extensive penile cancers; may precede radical procedures when tumor is smaller.
    38570Biopsy or excision of lymph node(s); open, superficialMay be used for diagnostic nodal sampling prior to or instead of formal lymphadenectomy.
    38745Radical excision of pelvic lymph nodes (separate procedure)Performed when more extensive pelvic nodal dissection is required in addition to inguinal nodes.
    49020Drainage of peritoneal abscess or hematoma (secondary procedures like drainage)May be reported for postoperative management of deep hematoma or abscess if surgically drained.
    99760Surgical team/critical care services (example post-op management)Represents intensive postoperative or wound care services provided after major oncologic surgery.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208600000X
    207L00000X
    208800000X
    225XG0600X
    2255A2300X
    2084V0102X
    207P00000X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-54100-PENILE-SKIN-LESION-BIOPSY-DIAGNOSTIC

    CPT 54100: Penile Skin Lesion Biopsy

    CPT-54105-PENILE-BIOPSY-DEEP-SKIN-LESION

    CPT 54105: Biopsy of Deep Skin Lesions of the Penis

    CPT-54110-PENILE-PLAQUE-EXCISION-PEYRONIES-DISEASE

    CPT 54110: Penile Plaque Excision for Peyronie’s Disease

    CPT-54111-EXCISION-PLAQUE-PENILE-SKIN-GRAFT-PEYRONIES-DISEASE

    CPT 54111: Penile Plaque Excision with Skin Graft up to 5 cm

    CPT-54112-PENILE-PLA-QUE-EXCISION-SKIN-GRAFT

    CPT 54112: Penile Plaque Excision with Skin Graft >5 cm

    CPT-54115-PENILE-IMPLANT-OR-DEEP-PENILE-FOREIGN-BODY-REMOVAL

    CPT 54115: Removal of Penile Implant or Foreign Body

    CPT-54120-PARTIAL-PENECTOMY-PENILE-RESECTION

    CPT 54120: Partial Penectomy for Injury or Disease

    CPT-54125-TOTAL-PENECTOMY

    CPT 54125: Total Penectomy (Complete Removal of Penis)

    CPT-54130-TOTAL-PENECTOMY-WITH-INGUINAL-LYMPHADENECTOMY

    CPT 54130: Total Penectomy with Inguinal Lymphadenectomy

    CPT-54150-CIRCUMCISION-CLAMP-DEVICE-WITH-REGIONAL-BLOCK

    CPT 54150: Circumcision with Clamp or Device, Regional Block

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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