CPT code 54135 denotes radical penectomy with bilateral inguinal lymphadenectomy, a major oncologic operation used for advanced or refractory penile cancer. Nationally, this code represents definitive surgical management for cases where tumor size, depth, or failure of conservative treatments necessitate removal of the entire organ and associated regional lymph nodes. The procedure has implications for surgical oncology capacity, post‑operative inpatient resources, and long‑term survivorship and rehabilitation services.

Key payers covered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare and Medicare. Readers will find a concise clinical context for the code, an overview of settings where the service is typically performed, and what to expect in claims and billing workflows for major ablative urologic oncology procedures. The publication summarizes benchmark considerations, common modifiers and reporting practices, and highlights policy and coverage elements relevant to high‑acuity inpatient surgical care. This information is intended to aid coding professionals, revenue cycle staff, and clinical leaders who manage complex oncologic surgeries and related claims.