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    OpenPayerBilling CodesExcision Procedures on the PenisCPT cpt-54105-penile-biopsy-deep-skin-lesion
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    CPT 54105: Biopsy of Deep Skin Lesions of the Penis

    Medicare pays $295 on average nationally for this procedure.

    CPT code 54105 describes a diagnostic procedure in which the provider performs a biopsy of the penis to obtain tissue samples from deep skin lesions; this is a surgical diagnostic service typically performed in an outpatient surgical suite, ambulatory surgery center, or procedure room within a clinic or hospital setting.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A male patient presents to a urology or dermatology clinic with a persistent, suspicious lesion of the penis (for example, a firm indurated nodule, ulcerated lesion, or atypical pigmented lesion) that requires histologic diagnosis. Typical presentation includes localized pain, bleeding, change in lesion appearance, failure to respond to topical therapy, or concern for malignancy such as squamous cell carcinoma or penile intraepithelial neoplasia. The provider obtains informed consent, examines the lesion, prepares the area with antiseptic and local anesthesia, and performs a deep incisional or punch biopsy of the penile dermis to obtain adequate tissue for pathologic evaluation. Specimens are handled per laboratory protocol (labeled, preserved in formalin, and submitted with relevant clinical history). The patient is given wound care instructions and arranged for pathology results and any required follow-up, such as further excision, staging, or oncology referral based on histopathology.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11102Tangential biopsy of skin (e.g., shave, scoop), single lesion; first lesionPerformed for superficial lesions when full-thickness sampling is not required; may be an alternative to deep biopsy if indicated
    11104Tangential biopsy, single lesion, each additional lesion (List separately in addition to code for primary procedure)Used when multiple superficial lesions are sampled during the same encounter
    11107Punch biopsy of skin, including simple closure, single lesionCommon alternative technique for obtaining full-thickness skin samples of small penile lesions
    11440Excision, benign lesion including margins, trunk, arms, legs; excised diameter 0.5 cm or lessUsed when diagnostic biopsy leads to subsequent complete excision of a benign lesion
    11606Excision, malignant lesion including margins, trunk, arms, legs; excised diameter 0.5 to 0.9 cmMay be used if biopsy confirms malignancy and definitive excision is performed on the penis (select appropriate anatomic code and size)
    88305Level IV surgical pathology, gross and microscopic examinationRepresents a commonly billed pathology code for evaluation of tissue from a deep skin biopsy; billed by pathology for specimen interpretation

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    57CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…
    58Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207N00000X
    363L00000X
    261QM2500X
    207QB0002X
    133VN1501X
    363LP0222X
    207XS0117X
    2278C0205X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-54100-PENILE-SKIN-LESION-BIOPSY-DIAGNOSTIC

    CPT 54100: Penile Skin Lesion Biopsy

    CPT-54110-PENILE-PLAQUE-EXCISION-PEYRONIES-DISEASE

    CPT 54110: Penile Plaque Excision for Peyronie’s Disease

    CPT-54111-EXCISION-PLAQUE-PENILE-SKIN-GRAFT-PEYRONIES-DISEASE

    CPT 54111: Penile Plaque Excision with Skin Graft up to 5 cm

    CPT-54112-PENILE-PLA-QUE-EXCISION-SKIN-GRAFT

    CPT 54112: Penile Plaque Excision with Skin Graft >5 cm

    CPT-54115-PENILE-IMPLANT-OR-DEEP-PENILE-FOREIGN-BODY-REMOVAL

    CPT 54115: Removal of Penile Implant or Foreign Body

    CPT-54120-PARTIAL-PENECTOMY-PENILE-RESECTION

    CPT 54120: Partial Penectomy for Injury or Disease

    CPT-54125-TOTAL-PENECTOMY

    CPT 54125: Total Penectomy (Complete Removal of Penis)

    CPT-54130-TOTAL-PENECTOMY-WITH-INGUINAL-LYMPHADENECTOMY

    CPT 54130: Total Penectomy with Inguinal Lymphadenectomy

    CPT-54135-RADICAL-PENECTOMY-BILATERAL-INGUINAL-LYMPHADENECTOMY

    CPT 54135: Radical Penectomy with Inguinal Lymphadenectomy

    CPT-54150-CIRCUMCISION-CLAMP-DEVICE-WITH-REGIONAL-BLOCK

    CPT 54150: Circumcision with Clamp or Device, Regional Block

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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