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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the PenisCPT cpt-54125-total-penectomy
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    CPT 54125: Total Penectomy (Complete Removal of Penis)

    Medicare pays $760 on average nationally for this procedure.

    CPT code 54125 describes the complete surgical removal of the penis (total penectomy) performed to treat severe injury or disease; this is an operative procedure typically provided as inpatient or major ambulatory surgical care in an operating room by a urologic or surgical specialist.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult male presenting with a non-reconstructable malignant tumor of the penis (for example, squamous cell carcinoma with extensive local invasion) or catastrophic traumatic injury with devitalized tissue and uncontrollable sepsis/hemorrhage. The patient has undergone preoperative evaluation including oncology staging or trauma assessment, laboratory testing, and anesthesia evaluation. The urologic surgical team obtains informed consent for total penectomy and possible perineal urethrostomy or urinary diversion. In the operating room under appropriate anesthesia, the surgeon performs a complete removal of the penis (CPT 54125), achieves hemostasis, and reconstructs the urinary stream as indicated (perineal urethrostomy or staged reconstruction). Postoperative care includes monitoring for bleeding, infection, urinary function, pain control, wound care, pathology review of the specimen, and coordination with oncology, plastic surgery, or rehabilitation depending on etiology. Typical sites of service are the hospital inpatient setting for oncologic or complex trauma cases, or an ambulatory surgical center only when clinically appropriate and safe for the patient’s condition.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54120Partial penectomy (without urethral reconstruction)Performed when organ-sparing resection is feasible; may precede or be chosen instead of CPT 54125.
    54300Amputation of penis, partial; including simple closureAlternative partial amputation codes for less extensive disease or trauma.
    54320Excision of lesion of penis (e.g., biopsy, excision of melanoma)Diagnostic or staging procedures performed before deciding on total penectomy.
    50960Urethral meatoscopy, therapeutic excluding endoscopic; dilation, meatotomy, or meatoplastyProcedures to manage or reconstruct the urethral meatus often performed concurrently or subsequently.
    53600Urethroplasty, repair with graft (simple)Reconstructive procedures for urethral diversion or creation of perineal urethrostomy may be staged after penectomy.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    208600000X
    207L00000X
    363L00000X
    172P00000X
    1223E0200X
    281P00000X
    2084P0804X

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    C60.0Malignant neoplasm of prepuce
    C60.1Malignant neoplasm of glans penis
    C60.2Malignant neoplasm of body of penis
    C60.9Malignant neoplasm of penis, unspecified
    C79.11Secondary malignant neoplasm of bladder
    D07.5Carcinoma in situ of prostate
    D29.1Benign neoplasm of prostate
    I96Gangrene, not elsewhere classified
    L98.8Other specified disorders of the skin and subcutaneous tissue
    L98.9Disorder of the skin and subcutaneous tissue, unspecified

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-54100-PENILE-SKIN-LESION-BIOPSY-DIAGNOSTIC

    CPT 54100: Penile Skin Lesion Biopsy

    CPT-54105-PENILE-BIOPSY-DEEP-SKIN-LESION

    CPT 54105: Biopsy of Deep Skin Lesions of the Penis

    CPT-54110-PENILE-PLAQUE-EXCISION-PEYRONIES-DISEASE

    CPT 54110: Penile Plaque Excision for Peyronie’s Disease

    CPT-54111-EXCISION-PLAQUE-PENILE-SKIN-GRAFT-PEYRONIES-DISEASE

    CPT 54111: Penile Plaque Excision with Skin Graft up to 5 cm

    CPT-54112-PENILE-PLA-QUE-EXCISION-SKIN-GRAFT

    CPT 54112: Penile Plaque Excision with Skin Graft >5 cm

    CPT-54115-PENILE-IMPLANT-OR-DEEP-PENILE-FOREIGN-BODY-REMOVAL

    CPT 54115: Removal of Penile Implant or Foreign Body

    CPT-54120-PARTIAL-PENECTOMY-PENILE-RESECTION

    CPT 54120: Partial Penectomy for Injury or Disease

    CPT-54130-TOTAL-PENECTOMY-WITH-INGUINAL-LYMPHADENECTOMY

    CPT 54130: Total Penectomy with Inguinal Lymphadenectomy

    CPT-54135-RADICAL-PENECTOMY-BILATERAL-INGUINAL-LYMPHADENECTOMY

    CPT 54135: Radical Penectomy with Inguinal Lymphadenectomy

    CPT-54150-CIRCUMCISION-CLAMP-DEVICE-WITH-REGIONAL-BLOCK

    CPT 54150: Circumcision with Clamp or Device, Regional Block

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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