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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the PenisCPT cpt-54130-total-penectomy-with-inguinal-lymphadenectomy
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    CPT 54130: Total Penectomy with Inguinal Lymphadenectomy

    Medicare pays $1087 on average nationally for this procedure.

    CPT code 54130 describes a total penectomy with inguinal lymphadenectomy, a surgical oncology procedure in which the provider completely removes the penis along with regional groin lymph nodes to treat advanced or extensive penile cancer; this service is an extirpative oncologic procedure typically performed in an inpatient hospital operating room with perioperative hospitalization and postoperative inpatient care.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a male in his 50s–70s presenting with an ulcerative or exophytic penile mass with progressive growth, bleeding, pain, and/or fixed inguinal lymphadenopathy. Prior management often includes biopsy confirming invasive squamous cell carcinoma and staging imaging (CT or PET/CT) demonstrating extensive primary tumor involving the penile shaft and possible regional nodal metastases. Multidisciplinary evaluation (urology, medical oncology, radiation oncology) determines that organ‑preserving surgery or partial penectomy is not feasible due to tumor size, multifocality, or depth of invasion; or the disease is recurrent after prior therapy.

    The clinical workflow includes preoperative staging and optimization, informed consent discussing radical penectomy with bilateral inguinal lymphadenectomy, marking of incision lines, general anesthesia, intraoperative removal of the entire penis and relevant superficial and deep inguinal lymph nodes, hemostasis and reconstruction or perineal urethrostomy when indicated, placement of drains, and postoperative monitoring for wound complications, lymphatic drainage issues, and urinary function. Pathology confirms margins and nodal status, guiding adjuvant therapy decisions such as radiation or systemic therapy. Typical site of service is an inpatient surgical setting at an acute care hospital; the service type is major operative oncology surgery for penile cancer.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54120Partial penectomy (removal of portion of penis)Performed when tumor extent allows organ preservation; may be an alternative to 54130 for smaller lesions.
    38999Unlisted procedure, hemic node dissection or lymph node excision (if specific inguinal nodal codes not applicable)Used to report atypical or extensive nodal dissections not described by standard codes; may be used adjunctively with penectomy when nodal work exceeds typical descriptors.
    38745Radical or modified radical bilateral inguinal lymphadenectomyCommonly performed at same operative session for regional nodal clearance and staging; directly related to management of penile cancer.
    51960Perineal urethrostomyPerformed when urethral diversion is required after radical penectomy to establish a permanent urinary stoma.
    15734Muscle, myocutaneous or fasciocutaneous flap; trunk (includes pedicle or free flap)Performed when reconstructive flap coverage is required for large defects after radical resection.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208600000X
    363L00000X
    2084P0800X
    207PT0002X
    2080C0008X
    177F00000X
    207RA0002X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    C60.0Malignant neoplasm of prepuce
    C60.1Malignant neoplasm of glans penis
    C60.2Malignant neoplasm of body of penis
    C60.9Malignant neoplasm of penis, unspecified
    C76.2Malignant neoplasm of abdomen
    C77.3Secondary and unspecified malignant neoplasm of axilla and upper limb lymph nodes
    C79.11Secondary malignant neoplasm of bladder
    C79.2Secondary malignant neoplasm of skin
    C79.9Secondary malignant neoplasm of unspecified site
    D07.5Carcinoma in situ of prostate

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-54100-PENILE-SKIN-LESION-BIOPSY-DIAGNOSTIC

    CPT 54100: Penile Skin Lesion Biopsy

    CPT-54105-PENILE-BIOPSY-DEEP-SKIN-LESION

    CPT 54105: Biopsy of Deep Skin Lesions of the Penis

    CPT-54110-PENILE-PLAQUE-EXCISION-PEYRONIES-DISEASE

    CPT 54110: Penile Plaque Excision for Peyronie’s Disease

    CPT-54111-EXCISION-PLAQUE-PENILE-SKIN-GRAFT-PEYRONIES-DISEASE

    CPT 54111: Penile Plaque Excision with Skin Graft up to 5 cm

    CPT-54112-PENILE-PLA-QUE-EXCISION-SKIN-GRAFT

    CPT 54112: Penile Plaque Excision with Skin Graft >5 cm

    CPT-54115-PENILE-IMPLANT-OR-DEEP-PENILE-FOREIGN-BODY-REMOVAL

    CPT 54115: Removal of Penile Implant or Foreign Body

    CPT-54120-PARTIAL-PENECTOMY-PENILE-RESECTION

    CPT 54120: Partial Penectomy for Injury or Disease

    CPT-54125-TOTAL-PENECTOMY

    CPT 54125: Total Penectomy (Complete Removal of Penis)

    CPT-54135-RADICAL-PENECTOMY-BILATERAL-INGUINAL-LYMPHADENECTOMY

    CPT 54135: Radical Penectomy with Inguinal Lymphadenectomy

    CPT-54150-CIRCUMCISION-CLAMP-DEVICE-WITH-REGIONAL-BLOCK

    CPT 54150: Circumcision with Clamp or Device, Regional Block

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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