CPT code 54110 covers surgical excision of penile plaque or abnormal fibrous tissue to correct deformity from Peyronie’s disease, including severe curvature, painful erections, palpable shaft nodules, and penile shortening. This procedure is an important urologic intervention for patients with functional impairment or significant pain and has relevance for surgical practices, health plans, and Medicare given the potential impact on quality of life and need for specialized operative care. Key payers in national coverage discussions include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find clinical context on the purpose and typical settings for the procedure, benchmarks and utilization considerations where available, and summaries of common billing practices tied to this code. The publication provides a concise reference for coding teams, revenue cycle staff, and policy analysts who manage or evaluate coverage and reimbursement for surgical treatment of Peyronie’s disease. Data not available in the input is noted where relevant.