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    OpenPayerBilling CodesExcision Procedures on the PenisCPT cpt-54110-penile-plaque-excision-peyronies-disease
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    CPT 54110: Penile Plaque Excision for Peyronie’s Disease

    Medicare pays $579 on average nationally for this procedure.

    CPT code 54110 describes surgical excision of penile plaque or abnormal fibrous tissue to correct Peyronie’s disease, performed to address severe penile curvature, pain with erection, palpable shaft lumps, or penile shortening; this is a surgical corrective procedure typically performed in an operating room or ambulatory surgery center under regional or general anesthesia and involves removal of scar tissue to restore penile form and function.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old man with a 2-year history of progressive penile curvature and intermittent pain during erection presents for surgical management of Peyronie’s disease. Prior conservative measures (oral therapy and intralesional collagenase) produced inadequate correction and persistent functional impairment during intercourse. Examination demonstrates a dorsal plaque along the midshaft with a 60-degree curvature and mild shortening. Preoperative workup includes sexual history, objective curvature measurement, penile duplex ultrasound to assess plaque and vascular status, and counseling about risks including erectile dysfunction and penile shortening. The procedure performed is excision of the fibrous plaque in the tunica albuginea with primary repair, coded as 54110. Typical intraoperative workflow includes general or regional anesthesia, exposure of the dorsal penis, dissection to the plaque, excision of abnormal fibrous tissue, and repair with or without grafting (if grafting occurs, additional codes may apply). Postoperative care includes pain control, wound care, follow-up for wound healing, and assessment of erectile function and penile straightening. Typical site of service is an ambulatory surgery center or hospital operating room.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54110Excision of plaque, or abnormal fibrous tissue, in the penis (Peyronie’s disease)Primary procedure for surgical correction of Peyronie’s disease.
    54111Excision of plaque and graft; with grafting of the tunica albugineaUsed when excision requires placement of a graft to repair the tunica after plaque removal; performed as an extension of 54110 when grafting is necessary.
    54113Repair of penis injury, complicated (including grafts)May be used for complex reconstructive repairs when the defect after plaque excision requires more extensive reconstruction.
    54120Penile implant procedures (insertion)May be performed in patients with concurrent severe erectile dysfunction or when prosthesis is placed during reconstruction.
    54050Circumcision, simple; newborn or otherPerformed separately if exposure or access requires circumcision prior to plaque excision in select cases.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208800000X
    163W00000X
    374U00000X
    171WV0202X
    333600000X
    163WC3500X
    207ZP0104X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-54100-PENILE-SKIN-LESION-BIOPSY-DIAGNOSTIC

    CPT 54100: Penile Skin Lesion Biopsy

    CPT-54105-PENILE-BIOPSY-DEEP-SKIN-LESION

    CPT 54105: Biopsy of Deep Skin Lesions of the Penis

    CPT-54111-EXCISION-PLAQUE-PENILE-SKIN-GRAFT-PEYRONIES-DISEASE

    CPT 54111: Penile Plaque Excision with Skin Graft up to 5 cm

    CPT-54112-PENILE-PLA-QUE-EXCISION-SKIN-GRAFT

    CPT 54112: Penile Plaque Excision with Skin Graft >5 cm

    CPT-54115-PENILE-IMPLANT-OR-DEEP-PENILE-FOREIGN-BODY-REMOVAL

    CPT 54115: Removal of Penile Implant or Foreign Body

    CPT-54120-PARTIAL-PENECTOMY-PENILE-RESECTION

    CPT 54120: Partial Penectomy for Injury or Disease

    CPT-54125-TOTAL-PENECTOMY

    CPT 54125: Total Penectomy (Complete Removal of Penis)

    CPT-54130-TOTAL-PENECTOMY-WITH-INGUINAL-LYMPHADENECTOMY

    CPT 54130: Total Penectomy with Inguinal Lymphadenectomy

    CPT-54135-RADICAL-PENECTOMY-BILATERAL-INGUINAL-LYMPHADENECTOMY

    CPT 54135: Radical Penectomy with Inguinal Lymphadenectomy

    CPT-54150-CIRCUMCISION-CLAMP-DEVICE-WITH-REGIONAL-BLOCK

    CPT 54150: Circumcision with Clamp or Device, Regional Block

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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