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    OpenPayerBilling CodesEndoscopic Retrograde Cholangiopancreatography (ERCP) ProceduresCPT cpt-43263-endoscopic-ercp-with-sphincter-of-oddi-manometry
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    CPT 43263: Endoscopic Retrograde Cholangiopancreatography with Sphincter of Oddi Manometry

    Medicare pays $318 on average nationally for this procedure.

    CPT code 43263 describes a combined diagnostic endoscopic procedure—upper endoscopy with retrograde injection of contrast into the biliary tree (endoscopic retrograde cholangiopancreatography) with fluoroscopic imaging of the gallbladder, pancreas, and bile ducts and measurement of sphincter of Oddi pressure; service type: diagnostic endoscopic/fluoroscopic biliary evaluation with sphincter of Oddi manometry; typical site of service: hospital outpatient endoscopy suite or ambulatory surgery center.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 46-year-old female presents with recurrent right upper-quadrant abdominal pain, intermittent jaundice, and abnormal liver function tests suggestive of biliary obstruction. Noninvasive imaging (abdominal ultrasound and MRCP) shows dilated bile ducts without a clear obstructing stone on ultrasound. The gastroenterologist schedules an endoscopic retrograde cholangiopancreatography with sphincter of Oddi manometry to evaluate for choledocholithiasis, biliary strictures, or sphincter of Oddi dysfunction. The procedure is performed in an outpatient endoscopy suite or ambulatory surgery center under monitored anesthesia care or general anesthesia depending on patient comorbidities. During the procedure the provider performs an upper endoscopy to reach the ampulla, cannulates the biliary system, injects contrast for fluoroscopic cholangiography, obtains diagnostic images of the bile ducts and pancreatic duct as indicated, and measures sphincter of Oddi pressures using a manometry catheter. Specimens or therapeutic interventions (stone extraction, sphincterotomy) are not part of this diagnostic code unless billed separately. Typical documentation includes indication, pre-procedure consent, anesthesia type, endoscopic findings, cannulation attempts, fluoroscopic images obtained, measured sphincter pressures with interpretation, and any immediate complications and post-procedure plan.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43260Esophagogastroduodenoscopy, flexible, transoral; diagnostic, with or without collection of specimen(s) by brushing or washing when performed (separate procedure)Performed to visualize upper GI tract and ampulla; may be reported if diagnostic endoscopy is performed separately from ERCP/manometry.
    43264Endoscopic retrograde cholangiopancreatography, diagnostic, with or without collection of specimen(s) by brushing or washing when performed (includes performance of sphincterotomy when performed)Related diagnostic ERCP code; therapeutic maneuvers such as sphincterotomy would be reported with appropriate therapeutic ERCP codes rather than pure manometry code alone.
    43262Endoscopic retrograde cholangiopancreatography, diagnostic, with cannulation of the ampulla and contrast injection onlyRepresents diagnostic ERCP without manometry; may be billed when manometry is not performed.
    43264(duplicate) See aboveData not available in the input.
    43261Endoscopic retrograde cholangiopancreatography with placement of stent or drainageTherapeutic ERCP codes such as stent placement are commonly performed after diagnostic imaging identifies obstruction; these are billed in addition to or instead of diagnostic codes as appropriate.
    43255Endoscopic retrograde cholangiopancreatography with sphincterotomyTherapeutic sphincterotomy is billed when sphincter cutting is performed in conjunction with diagnostic evaluation or manometry.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RP1001X
    2080P0207X
    193200000X
    364SP0810X
    146N00000X
    163WX1100X
    204F00000X
    133VN1201X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 2

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43260-DIAGNOSTIC-ERCP-UPPER-ENDOSCOPY-BILIARY-CONTRAST

    CPT 43260: Diagnostic Upper Endoscopy with Cholangiography and Brushing

    CPT-43261-ERCP-WITH-BIOPSY-DIAGNOSTIC-ENDOSCOPY-BILIARY-PANCREATIC-IMAGING

    CPT 43261: Upper Endoscopy with ERCP and Biopsy

    CPT-43262-ERCP-SPHINCTEROTOMY-PAPILLOTOMY

    CPT 43262: ERCP with Sphincterotomy/Papillotomy

    CPT-43264-ERCP-ENDOSCOPY-DUCTAL-STONE-REMOVAL

    CPT 43264: ERCP with Diagnostic Imaging and Ductal Stone Removal

    CPT-43265-ERCP-THERAPEUTIC-PANCREATICOBILIARY-STONE-DESTRUCTION

    CPT 43265: ERCP with Stone Destruction and Radiologic Assessment of Biliary/Pancreatic Ducts

    CPT-43270-EGD-UPPER-GASTROINTESTINAL-ENDOSCOPY-WITH-ABLATION

    CPT 43270: Esophagogastroduodenoscopy with Dilation and Lesion Ablation

    CPT-43273-ERCP-VISUALIZATION-PANCREATIC-COMMON-BILE-DUCTS

    CPT 43273: ERCP Visualization of Pancreatic or Bile Ducts

    CPT-43274-ERCP-BILIARY-OR-PANCREATIC-DUCT-STENT-PLACEMENT

    CPT 43274: ERCP with Biliary or Pancreatic Duct Stent Placement

    CPT-43275-ERCP-ENDOSCOPIC-REMOVAL-BILIARY-PANCREATIC-STENT-FOREIGN-BODY

    CPT 43275: ERCP with Removal of Biliary/Pancreatic Foreign Body or Stent

    CPT-43276-ERCP-WITH-SINGLE-DUCT-STENT-REMOVAL-AND-EXCHANGE

    CPT 43276: ERCP with Single Duct Stent Removal and Exchange

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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