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    v1.0.30
    OpenPayerBilling CodesEndoscopic Retrograde Cholangiopancreatography (ERCP) ProceduresCPT cpt-43260-diagnostic-ercp-upper-endoscopy-biliary-contrast
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    CPT 43260: Diagnostic Upper Endoscopy with Cholangiography and Brushing

    Medicare pays $286 on average nationally for this procedure.

    CPT code 43260 describes a diagnostic endoscopic procedure combining upper endoscopy (esophagogastroduodenoscopy) with retrograde injection of contrast into the biliary ducts to obtain fluoroscopic images of the bile ducts, gallbladder, and pancreas; the procedure may include collection of specimens by brushing or washing for diagnostic analysis. Service type: diagnostic endoscopy with cholangiography and specimen collection. Typical site of service: hospital outpatient department or ambulatory surgical center.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 56-year-old patient presents with progressive jaundice, right upper quadrant pain, and abnormal liver function tests; cross-sectional imaging suggests a possible choledocholithiasis or obstructing biliary stricture. After initial evaluation in the outpatient clinic and failed noninvasive management, the gastroenterologist schedules an endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic evaluation. In the endoscopy suite or hospital endoscopy unit, under moderate sedation or monitored anesthesia care, the provider performs upper endoscopy to access the ampulla, cannulates the biliary tree, injects contrast retrograde into the bile ducts under fluoroscopy to delineate the common bile duct, intrahepatic ducts, cystic duct and pancreatic duct as indicated, and may obtain brushings, washings, or ductal aspirates for cytology or culture. The typical workflow includes pre-procedure consent and assessment, NPO status, anesthetic plan, prophylactic antibiotics if indicated, performance of diagnostic cholangiography with sampling as needed, post-procedure monitoring for complications (bleeding, pancreatitis, infection, perforation), and discharge instructions or inpatient admission based on procedural findings and patient stability.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43260Diagnostic endoscopic retrograde cholangiopancreatography with cholangiography; diagnostic, may include brushing or washing for analysisPrimary procedure: diagnostic ERCP with contrast injection into biliary ducts and possible specimen collection.
    43262Endoscopic retrograde cholangiopancreatography; with diagnostic cholangiography including sphincterotomy, stone removal, or stent placement (therapeutic)Performed when diagnostic findings necessitate therapeutic intervention such as sphincterotomy, stone extraction, or stent insertion during the same session.
    43274Endoscopic retrograde cholangiopancreatography with removal of calculus(es) from biliary tract, with or without sphincterotomyUsed when choledocholithiasis is identified and stones are removed during the ERCP.
    43269Endoscopic retrograde cholangiopancreatography with insertion of biliary stentUsed when a biliary obstruction requires temporary or permanent stent placement following diagnostic imaging.
    43255Upper gastrointestinal endoscopy, diagnostic, flexible, transoral; with biopsy(s)May be performed concurrently if mucosal biopsies of the ampulla or duodenum are required.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208000000X
    207RH0000X
    2084P0800X
    207K00000X
    1223X0008X
    332100000X
    207RH0003X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    K75.9Inflammatory liver disease, unspecified
    K80.10Calculus of gallbladder with chronic cholecystitis without obstruction
    K80.20Calculus of gallbladder without cholecystitis without obstruction
    K80.30Calculus of bile duct with cholangitis, unspecified, without obstruction
    K80.40Calculus of bile duct with cholecystitis, unspecified, without obstruction
    K80.50Calculus of bile duct without cholangitis or cholecystitis without obstruction
    K80.60Calculus of gallbladder and bile duct with cholecystitis, unspecified, without obstruction
    K81.0Acute cholecystitis
    K81.9Cholecystitis, unspecified
    K82.9Disease of gallbladder, unspecified

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 2

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43261-ERCP-WITH-BIOPSY-DIAGNOSTIC-ENDOSCOPY-BILIARY-PANCREATIC-IMAGING

    CPT 43261: Upper Endoscopy with ERCP and Biopsy

    CPT-43262-ERCP-SPHINCTEROTOMY-PAPILLOTOMY

    CPT 43262: ERCP with Sphincterotomy/Papillotomy

    CPT-43263-ENDOSCOPIC-ERCP-WITH-SPHINCTER-OF-ODDI-MANOMETRY

    CPT 43263: Endoscopic Retrograde Cholangiopancreatography with Sphincter of Oddi Manometry

    CPT-43264-ERCP-ENDOSCOPY-DUCTAL-STONE-REMOVAL

    CPT 43264: ERCP with Diagnostic Imaging and Ductal Stone Removal

    CPT-43265-ERCP-THERAPEUTIC-PANCREATICOBILIARY-STONE-DESTRUCTION

    CPT 43265: ERCP with Stone Destruction and Radiologic Assessment of Biliary/Pancreatic Ducts

    CPT-43270-EGD-UPPER-GASTROINTESTINAL-ENDOSCOPY-WITH-ABLATION

    CPT 43270: Esophagogastroduodenoscopy with Dilation and Lesion Ablation

    CPT-43273-ERCP-VISUALIZATION-PANCREATIC-COMMON-BILE-DUCTS

    CPT 43273: ERCP Visualization of Pancreatic or Bile Ducts

    CPT-43274-ERCP-BILIARY-OR-PANCREATIC-DUCT-STENT-PLACEMENT

    CPT 43274: ERCP with Biliary or Pancreatic Duct Stent Placement

    CPT-43275-ERCP-ENDOSCOPIC-REMOVAL-BILIARY-PANCREATIC-STENT-FOREIGN-BODY

    CPT 43275: ERCP with Removal of Biliary/Pancreatic Foreign Body or Stent

    CPT-43276-ERCP-WITH-SINGLE-DUCT-STENT-REMOVAL-AND-EXCHANGE

    CPT 43276: ERCP with Single Duct Stent Removal and Exchange

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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