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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of female genital organsICD-10-CM c52-malignant-neoplasm-of-vagina
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    ICD-10-CM Code For Malignant Neoplasm Of Vagina: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C52 includes malignant neoplasms originating in the vagina, such as squamous cell carcinoma and other primary vaginal cancers involving the vaginal mucosa and wall. These ICD-10-CM diagnosis codes are used to document primary vaginal cancer diagnoses, capturing anatomic site, extent of local invasion, and presence of metastasis when applicable. Accurate coding within the ICD-10-CM C52 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C52: Malignant Neoplasm Of Vagina Overview

    The diagnoses in this group represent malignant tumors originating in the vaginal tissue, including primary cancers of the vagina. These conditions affect the female genital organs and may involve local invasion or spread to adjacent structures. Accurate coding is important for clinical records, cancer registry reporting, and appropriate reimbursement.

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    When to Use

    Use a code from this group when a clinician documents a primary malignant neoplasm of the vagina based on histology, imaging, or clinical examination. Select the most specific code available to reflect site, laterality if specified, and documented extension or metastasis.

    ICD-10-CM Codes

    1 rows

    ICD-10-CM CodeDescription
    C52Malignant neoplasm of vagina

    DRG Codes

    9 rows

    DRG CodeDescription
    736Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with MCC
    737Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with CC
    738Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy without CC/MCC
    739Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy with MCC
    740Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy with CC
    741Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy without CC/MCC
    754Malignancy, Female Reproductive System with MCC
    755Malignancy, Female Reproductive System with CC
    756Malignancy, Female Reproductive System without CC/MCC

    Typical Clinical Scenarios

    • A postmenopausal woman presents to gynecologic oncology with a new vaginal bleeding and a palpable mass on pelvic exam; biopsy of the lesion confirms invasive carcinoma originating in the vaginal epithelium. She is referred for staging and treatment planning, and a malignant neoplasm of the vagina diagnosis is assigned to capture the primary vaginal cancer. Typical codes: C52
    • A middle-aged woman with a history of prior pelvic radiation for cervical cancer develops progressive vaginal pain, ulceration, and a nonhealing lesion checked during routine follow-up; biopsy demonstrates malignant cells consistent with a primary vaginal neoplasm rather than recurrent cervical disease. Because the malignant tumor is located in the vagina, a code from this group is used to document the current primary vaginal malignancy. Typical codes: C52
    • An elderly patient presents to the emergency department with acute urinary retention and obstructive uropathy caused by an enlarging vaginal tumor compressing the urethra; imaging and biopsy confirm a vaginal carcinoma as the source of mass effect. The acute complication and need for urgent management are coded along with the primary diagnosis of malignant vaginal neoplasm. Typical codes: C52

    Related Codes

    C51-MALIGNANT-NEOPLASM-OF-VULVA

    ICD-10-CM Code For Malignant Neoplasm Of Vulva: Group Overview

    C53-MALIGNANT-NEOPLASM-OF-CERVIX-UTERI

    ICD-10-CM Code For Malignant Neoplasm Of Cervix Uteri: Group Overview

    C54-MALIGNANT-NEOPLASM-OF-CORPUS-UTERI

    ICD-10-CM Code For Malignant Neoplasm Of Corpus Uteri: Group Overview

    C55-MALIGNANT-NEOPLASM-OF-UTERUS

    ICD-10-CM Code For Malignant Neoplasm Of Uterus Part Unspecified: Group Overview

    C56-MALIGNANT-NEOPLASM-OF-OVARY

    ICD-10-CM Code For Malignant Neoplasm Of Ovary: Group Overview

    C57-MALIGNANT-NEOPLASM-OTHER-FEMALE-GENITAL-ORGANS

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Female Genital Organs: Group Overview

    C58-MALIGNANT-NEOPLASM-OF-PLACENTA

    ICD-10-CM Code For Malignant Neoplasm Of Placenta: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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