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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of female genital organsICD-10-CM c51-malignant-neoplasm-of-vulva
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    ICD-10-CM Code For Malignant Neoplasm Of Vulva: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C51 includes cancers of the vulva, covering malignant neoplasms of specific vulvar subsites such as labia majora, labia minora, clitoris, and overlapping or unspecified vulvar locations. These ICD-10-CM diagnosis codes are used to document primary vulvar malignancy, extent of local involvement, and site-specific tumor classification to capture disease severity and anatomic detail. Accurate coding within the ICD-10-CM C51 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C51: Malignant Neoplasm Of Vulva Overview

    The ICD-10-CM C51 group represents cancers originating in the vulva, including specific subsites such as labia majora, labia minora, clitoris, and overlapping lesions. These diagnoses target the female external genital organs and related regional structures. Accurate coding matters for clinical continuity, tracking disease burden, and correct reimbursement determination.

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    When to Use

    Use a code from this group when documenting a confirmed primary malignant neoplasm of the vulva with specification of anatomical subsite when known. Select the most specific C51 code that reflects the documented vulvar location or specify overlapping or unspecified vulvar involvement if the exact subsite is not identified.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    C51.0Malignant neoplasm of labium majus
    C51.1Malignant neoplasm of labium minus
    C51.2Malignant neoplasm of clitoris
    C51.8Malignant neoplasm of overlapping sites of vulva
    C51.9Malignant neoplasm of vulva, unspecified

    DRG Codes

    9 rows

    DRG CodeDescription
    736Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with MCC
    737Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with CC
    738Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy without CC/MCC
    739Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy with MCC
    740Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy with CC
    741Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy without CC/MCC
    754Malignancy, Female Reproductive System with MCC
    755Malignancy, Female Reproductive System with CC
    756Malignancy, Female Reproductive System without CC/MCC

    Typical Clinical Scenarios

    • A 68-year-old woman presents to her gynecologist with a several-month history of a painful, slowly enlarging ulcerative lesion on the labia majora that has begun to bleed and cause local discomfort. Examination and biopsy confirm an invasive squamous cell carcinoma confined to the labia majora without involvement of adjacent structures; imaging shows no distant metastasis. A vulvar primary malignant neoplasm diagnosis is assigned to guide oncology staging and local treatment planning. Typical codes: C51.0, C51.9
    • A 52-year-old woman with a history of chronic vulvar lichen sclerosus develops a small nodular lesion on the labia minora found during routine dermatologic follow-up; excisional biopsy demonstrates invasive vulvar cancer limited to the labia minora. She is referred for surgical excision and possible lymph node assessment because the cancer arises in a high-risk chronic dermatosis and represents a new primary vulvar malignancy. Typical codes: C51.1, C51.9
    • A 74-year-old woman arrives to the emergency department with acute profuse vulvar bleeding and anemia from a friable, fungating vulvar mass; biopsy and urgent surgical evaluation confirm advanced vulvar malignancy involving overlapping vulvar sites and requiring combined local control and systemic management. The diagnosis code selected reflects a malignant neoplasm of an overlapping or multiple vulvar subsite when the lesion spans more than one specific anatomic area. Typical codes: C51.8, C51.2

    Related Codes

    C52-MALIGNANT-NEOPLASM-OF-VAGINA

    ICD-10-CM Code For Malignant Neoplasm Of Vagina: Group Overview

    C53-MALIGNANT-NEOPLASM-OF-CERVIX-UTERI

    ICD-10-CM Code For Malignant Neoplasm Of Cervix Uteri: Group Overview

    C54-MALIGNANT-NEOPLASM-OF-CORPUS-UTERI

    ICD-10-CM Code For Malignant Neoplasm Of Corpus Uteri: Group Overview

    C55-MALIGNANT-NEOPLASM-OF-UTERUS

    ICD-10-CM Code For Malignant Neoplasm Of Uterus Part Unspecified: Group Overview

    C56-MALIGNANT-NEOPLASM-OF-OVARY

    ICD-10-CM Code For Malignant Neoplasm Of Ovary: Group Overview

    C57-MALIGNANT-NEOPLASM-OTHER-FEMALE-GENITAL-ORGANS

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Female Genital Organs: Group Overview

    C58-MALIGNANT-NEOPLASM-OF-PLACENTA

    ICD-10-CM Code For Malignant Neoplasm Of Placenta: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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