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    v1.0.28
    OpenPayerBilling CodesMalignant neoplasms of lip, oral cavity and pharynxICD-10-CM c00-malignant-neoplasm-of-lip
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    ICD-10-CM Code For Malignant Neoplasm Of Lip: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C00 includes malignant neoplasms of the lip, covering cancers of the external and mucosal lip surfaces at specific anatomic sites and overlapping lip lesions. These ICD-10-CM diagnosis codes are used to document primary lip cancers, capture tumor site specificity and any extension to adjacent structures, and reflect laterality where applicable. Accurate coding within the ICD-10-CM C00 group supports proper claim adjudication, complete clinical documentation and appropriate reimbursement.

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    ICD-10-CM C00: Malignant Neoplasm Of Lip Overview

    This group represents malignant tumors originating on the lip, including specific anatomic sites of the upper and lower lip and overlapping lesions. These diagnoses target cancers of the oral region and adjacent mucocutaneous tissues. Accurate coding is important to reflect tumor site and extent, which affects clinical documentation and reimbursement.

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    When to Use

    Use codes from this group when documenting a primary malignant tumor of the lip confirmed by clinical, imaging, or histopathologic evaluation. Select the code that specifies the exact lip subsite and laterality to reflect the documented tumor location.

    ICD-10-CM Codes

    9 rows

    ICD-10-CM CodeDescription
    C00.0Malignant neoplasm of external upper lip
    C00.1Malignant neoplasm of external lower lip
    C00.2Malignant neoplasm of external lip, unspecified
    C00.3Malignant neoplasm of upper lip, inner aspect
    C00.4Malignant neoplasm of lower lip, inner aspect
    C00.5Malignant neoplasm of lip, unspecified, inner aspect
    C00.6Malignant neoplasm of commissure of lip, unspecified
    C00.8Malignant neoplasm of overlapping sites of lip
    C00.9Malignant neoplasm of lip, unspecified

    DRG Codes

    6 rows

    DRG CodeDescription
    011Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
    012Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
    013Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
    146Ear, Nose, Mouth and Throat Malignancy with MCC
    147Ear, Nose, Mouth and Throat Malignancy with CC
    148Ear, Nose, Mouth and Throat Malignancy without CC/MCC

    Typical Clinical Scenarios

    • An older adult with a long history of tobacco and heavy alcohol use presents to the otolaryngology clinic with a slowly enlarging, ulcerated lesion on the vermilion border of the lower lip that bleeds intermittently and has a palpable indurated margin. Biopsy confirms invasive squamous cell carcinoma of the external lower lip, and staging and treatment planning are initiated; this diagnosis is assigned to describe a primary malignant lesion of the lip. Typical codes: C00.3, C00.4
    • A middle-aged patient is brought to the emergency department after facial trauma and is found to have a rapidly enlarging, painful mass of the upper lip with new onset ulceration and associated regional lymphadenopathy; imaging and urgent biopsy identify a malignant neoplasm of the upper lip requiring prompt oncology and surgical evaluation. The acute presentation with suspected primary lip malignancy leads to assignment of a specific code for the upper lip tumor. Typical codes: C00.0, C00.1
    • A patient with a history of treated lip cancer presents during routine follow-up with a new non-healing lesion at the commissure and biopsy-proven recurrent carcinoma at the corner of the mouth; management focuses on re-resection and assessment for metastatic spread. Coding reflects the malignant neoplasm located at the lip commissure or overlapping sites as part of surveillance and recurrence care. Typical codes: C00.2, C00.8

    Related Codes

    C01-MALIGNANT-NEOPLASM-BASE-OF-TONGUE

    ICD-10-CM Code For Malignant Neoplasm Of Base Of Tongue: Group Overview

    C02-MALIGNANT-NEOPLASM-OF-TONGUE

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Parts Of Tongue: Group Overview

    C03-MALIGNANT-NEOPLASM-OF-GUM

    ICD-10-CM Code For Malignant Neoplasm Of Gum: Group Overview

    C04-MALIGNANT-NEOPLASM-OF-FLOOR-OF-MOUTH

    ICD-10-CM Code For Malignant Neoplasm Of Floor Of Mouth: Group Overview

    C05-MALIGNANT-NEOPLASM-OF-PALATE

    ICD-10-CM Code For Malignant Neoplasm Of Palate: Group Overview

    C06-MALIGNANT-NEOPLASM-OF-MOUTH

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Parts Of Mouth: Group Overview

    C07-MALIGNANT-NEOPLASM-OF-PAROTID-GLAND

    ICD-10-CM Code For Malignant Neoplasm Of Parotid Gland: Group Overview

    C08-MALIGNANT-SALIVARY-GLAND-NEOPLASMS

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Major Salivary Glands: Group Overview

    C09-MALIGNANT-NEOPLASM-OF-TONSIL

    ICD-10-CM Code For Malignant Neoplasm Of Tonsil: Group Overview

    C10-MALIGNANT-NEOPLASM-OF-OROPHARYNX

    ICD-10-CM Code For Malignant Neoplasm Of Oropharynx: Group Overview

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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