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    v1.0.28
    OpenPayerBilling CodesCertain zoonotic bacterial diseasesICD-10-CM a27-leptospirosis
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    ICD-10-CM Code For Leptospirosis: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group A27 includes diagnoses for leptospirosis, a zoonotic infection caused by Leptospira species that can affect the liver, kidneys, and other organ systems and may present as mild or severe disease. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as acute febrile illness with organ involvement, Weil disease, and other manifestations that capture disease severity and organ system complications. Accurate coding within the ICD-10-CM A27 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM A27: Leptospirosis Overview

    The ICD-10-CM A27 group covers leptospirosis, a zoonotic bacterial infection that primarily affects the liver, kidneys, and other organ systems. These diagnoses represent infection by Leptospira species and range from mild, flu-like illness to severe, multi-organ disease. Accurate coding is important to reflect clinical severity and support appropriate reimbursement and public health reporting.

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    When to Use

    Use a code from this group when a patient has a confirmed or clinically diagnosed leptospiral infection with documented signs, symptoms, or organ dysfunction attributable to the infection. Select the code that reflects the severity and specific manifestations such as renal failure, hepatic involvement, or other systemic complications.

    ICD-10-CM Codes

    4 rows

    ICD-10-CM CodeDescription
    A27.0Leptospirosis icterohemorrhagica
    A27.81Aseptic meningitis in leptospirosis
    A27.89Other forms of leptospirosis
    A27.9Leptospirosis, unspecified

    DRG Codes

    8 rows

    DRG CodeDescription
    023Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
    024Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
    097Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
    098Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
    099Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
    867Other Infectious and Parasitic Diseases Diagnoses with MCC
    868Other Infectious and Parasitic Diseases Diagnoses with CC
    869Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • A middle-aged farmer presents to the emergency department with high fever, severe myalgias, conjunctival suffusion, and jaundice after wading through flooded rice paddies 10 days earlier; laboratory studies show elevated bilirubin and acute kidney injury with rising creatinine. Because this is an acute systemic zoonotic infection with hepatic and renal involvement consistent with severe leptospirosis, an acute leptospiral infection code is assigned. Typical codes: A27.0, A27.81
    • A young athlete develops persistent low-grade fever, malaise, and intermittent headaches for several weeks after a recreational freshwater swim; symptoms are milder without organ failure but last beyond the expected acute phase, prompting outpatient infectious disease follow-up. In the setting of ongoing signs attributed to a leptospiral infection without severe systemic complications, a non-severe leptospirosis code is used for continued management and surveillance. Typical codes: A27.81, A27.9
    • An older hospitalized patient with known leptospirosis is evaluated for cardiac and pulmonary complications, including new-onset arrhythmia and pulmonary hemorrhage, requiring critical care; these findings represent complications of the primary zoonotic bacterial disease and alter management and prognosis. When leptospiral infection is documented as the underlying cause of these serious complications, a code indicating leptospirosis with specified complications is assigned. Typical codes: A27.89, A27.0

    Related Codes

    A20-PLAGUE

    ICD-10-CM Code For Plague: Group Overview

    A21-TULAREMIA

    ICD-10-CM Code For Tularemia: Group Overview

    A22-ANTHRAX

    ICD-10-CM Code For Anthrax: Group Overview

    A23-BRUCELLOSIS

    ICD-10-CM Code For Brucellosis: Group Overview

    A24-GLANDERS-AND-MELIOIDOSIS

    ICD-10-CM Code For Glanders And Melioidosis: Group Overview

    A25-RAT-BITE-FEVERS

    ICD-10-CM Code For Rat Bite Fevers: Group Overview

    A26-ERYSIPELOID-INFECTION

    ICD-10-CM Code For Erysipeloid: Group Overview

    A28-OTHER-ZOONOTIC-BACTERIAL-DISEASES

    ICD-10-CM Code For Other Zoonotic Bacterial Diseases Not Elsewhere Classified: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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