ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 0F5C includes procedures performed to destroy tissue in the ampulla of Vater. These ICD-10-PCS codes are used for inpatient documentation when a clinician performs direct destruction of all or a portion of the ampulla of Vater using energy, force, or a destructive agent. Accurate coding within the ICD-10-PCS 0F5C group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Ampulla Of Vater Destruction Procedure Overview

Procedures in this group involve the destruction of all or a portion of the ampulla of Vater within the hepatobiliary system and pancreas. These procedures use energy, force, or a destructive agent to eradicate targeted tissue and are coded in the Medical and Surgical section. Accurate coding is important for reflecting the clinical intervention performed and for appropriate inpatient reimbursement and case mix assignment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
0	Section	Medical and Surgical
F	Body System	Hepatobiliary System and Pancreas
5	Operation	Destruction
C	Body Part	Ampulla of Vater

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ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview

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Ampulla Of Vater Destruction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
0	Section	Medical and Surgical
F	Body System	Hepatobiliary System and Pancreas
5	Operation	Destruction
C	Body Part	Ampulla of Vater

When to Use

Use a code from this group when the clinical procedure involves direct destruction of the ampulla of Vater rather than excision or repair. These codes apply when the intent is eradication of tissue using destructive modalities during an inpatient encounter.

ICD-10-PCS Codes

8 rows

ICD-10-PCS Code	Description
0F5C0Z3	Destruction of Ampulla of Vater using Laser Interstitial Thermal Therapy, Open Approach
0F5C0ZZ	Destruction of Ampulla of Vater, Open Approach
0F5C3Z3	Destruction of Ampulla of Vater using Laser Interstitial Thermal Therapy, Percutaneous Approach
0F5C3ZZ	Destruction of Ampulla of Vater, Percutaneous Approach
0F5C4Z3	Destruction of Ampulla of Vater using Laser Interstitial Thermal Therapy, Percutaneous Endoscopic Approach
0F5C4ZZ	Destruction of Ampulla of Vater, Percutaneous Endoscopic Approach
0F5C7ZZ	Destruction of Ampulla of Vater, Via Natural or Artificial Opening
0F5C8ZZ	Destruction of Ampulla of Vater, Via Natural or Artificial Opening Endoscopic

DRG Codes

9 rows

DRG Code	Description
356	Other Digestive System O.R. Procedures with MCC
357	Other Digestive System O.R. Procedures with CC
358	Other Digestive System O.R. Procedures without CC/MCC
408	Biliary Tract Procedures Except Only Cholecystectomy with or without C.D.E. with MCC
409	Biliary Tract Procedures Except Only Cholecystectomy with or without C.D.E. with CC
410	Biliary Tract Procedures Except Only Cholecystectomy with or without C.D.E. without CC/MCC
987	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with MCC
988	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with CC
989	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis without CC/MCC

Typical Clinical Scenarios

An elderly patient presents to the hospital with acute cholangitis characterized by fever, jaundice, right upper quadrant pain, and sepsis from obstruction at the ampulla causing biliary stasis. Endoscopic attempts at stone removal were unsuccessful and the clinical team proceeds with endoscopic destructive ablation of the ampullary tissue to remove the obstructing lesion and restore biliary drainage during the inpatient encounter. The intent is direct eradication of ampullary tissue using an endoscopic destructive modality to relieve the obstruction and treat the infection. Typical codes: 0F5C4Z3, 0F5C4ZZ, 0F5C8ZZ
A middle-aged patient with recurrent ampullary adenomatous lesions undergoes a planned inpatient procedure for local eradication of the neoplastic tissue after multidisciplinary review. A percutaneous endoscopic approach using targeted energy is selected to ablate the residual adenoma while preserving surrounding pancreatic and biliary structures. The procedure is performed electively with the documented intent to destroy the ampullary lesion rather than excise it. Typical codes: 0F5C4Z3, 0F5C4ZZ
A patient previously treated with endoscopic sphincterotomy and stent placement develops recurrent ampullary hyperplasia and persistent obstructive symptoms; prior excisional attempts left residual tissue. During the inpatient admission for symptom control, the team performs percutaneous destruction of the persistent ampullary tissue using a destructive modality to eradicate the remnant and prevent further obstruction. This is a revision-style therapeutic destruction targeting remaining ampullary tissue. Typical codes: 0F5C3Z3, 0F5C3ZZ

Related Codes

0F50-LIVER-DESTRUCTION

ICD-10-PCS Code For Liver: Procedure Code Group Overview

0F51-LIVER-RIGHT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Right Lobe: Procedure Code Group Overview

0F52-LEFT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Left Lobe: Procedure Code Group Overview

0F54-GALLBLADDER-DESTRUCTION

ICD-10-PCS Code For Gallbladder: Procedure Code Group Overview

0F55-HEPATIC-DUCT-RIGHT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Right: Procedure Code Group Overview

0F56-LEFT-HEPATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct, Left: Procedure Code Group Overview

0F57-HEPATIC-DUCT-COMMON-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Common: Procedure Code Group Overview

0F58-CYSTIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Cystic Duct: Procedure Code Group Overview

0F59-COMMON-BILE-DUCT-DESTRUCTION

ICD-10-PCS Code For Common Bile Duct: Procedure Code Group Overview

0F5D-PANCREATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Pancreatic Duct: Procedure Code Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

8 rows

ICD-10-PCS Code	Description
0F5C0Z3	Destruction of Ampulla of Vater using Laser Interstitial Thermal Therapy, Open Approach
0F5C0ZZ	Destruction of Ampulla of Vater, Open Approach
0F5C3Z3	Destruction of Ampulla of Vater using Laser Interstitial Thermal Therapy, Percutaneous Approach
0F5C3ZZ	Destruction of Ampulla of Vater, Percutaneous Approach
0F5C4Z3	Destruction of Ampulla of Vater using Laser Interstitial Thermal Therapy, Percutaneous Endoscopic Approach
0F5C4ZZ	Destruction of Ampulla of Vater, Percutaneous Endoscopic Approach
0F5C7ZZ	Destruction of Ampulla of Vater, Via Natural or Artificial Opening
0F5C8ZZ	Destruction of Ampulla of Vater, Via Natural or Artificial Opening Endoscopic

DRG Codes

9 rows

DRG Code	Description
356	Other Digestive System O.R. Procedures with MCC
357	Other Digestive System O.R. Procedures with CC
358	Other Digestive System O.R. Procedures without CC/MCC
408	Biliary Tract Procedures Except Only Cholecystectomy with or without C.D.E. with MCC
409	Biliary Tract Procedures Except Only Cholecystectomy with or without C.D.E. with CC
410	Biliary Tract Procedures Except Only Cholecystectomy with or without C.D.E. without CC/MCC
987	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with MCC
988	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with CC
989	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis without CC/MCC

Typical Clinical Scenarios

An elderly patient presents to the hospital with acute cholangitis characterized by fever, jaundice, right upper quadrant pain, and sepsis from obstruction at the ampulla causing biliary stasis. Endoscopic attempts at stone removal were unsuccessful and the clinical team proceeds with endoscopic destructive ablation of the ampullary tissue to remove the obstructing lesion and restore biliary drainage during the inpatient encounter. The intent is direct eradication of ampullary tissue using an endoscopic destructive modality to relieve the obstruction and treat the infection. Typical codes: 0F5C4Z3, 0F5C4ZZ, 0F5C8ZZ
A middle-aged patient with recurrent ampullary adenomatous lesions undergoes a planned inpatient procedure for local eradication of the neoplastic tissue after multidisciplinary review. A percutaneous endoscopic approach using targeted energy is selected to ablate the residual adenoma while preserving surrounding pancreatic and biliary structures. The procedure is performed electively with the documented intent to destroy the ampullary lesion rather than excise it. Typical codes: 0F5C4Z3, 0F5C4ZZ
A patient previously treated with endoscopic sphincterotomy and stent placement develops recurrent ampullary hyperplasia and persistent obstructive symptoms; prior excisional attempts left residual tissue. During the inpatient admission for symptom control, the team performs percutaneous destruction of the persistent ampullary tissue using a destructive modality to eradicate the remnant and prevent further obstruction. This is a revision-style therapeutic destruction targeting remaining ampullary tissue. Typical codes: 0F5C3Z3, 0F5C3ZZ

Related Codes

0F50-LIVER-DESTRUCTION

ICD-10-PCS Code For Liver: Procedure Code Group Overview

0F51-LIVER-RIGHT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Right Lobe: Procedure Code Group Overview

0F52-LEFT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Left Lobe: Procedure Code Group Overview

0F54-GALLBLADDER-DESTRUCTION

ICD-10-PCS Code For Gallbladder: Procedure Code Group Overview

0F55-HEPATIC-DUCT-RIGHT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Right: Procedure Code Group Overview

0F56-LEFT-HEPATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct, Left: Procedure Code Group Overview

0F57-HEPATIC-DUCT-COMMON-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Common: Procedure Code Group Overview

0F58-CYSTIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Cystic Duct: Procedure Code Group Overview

0F59-COMMON-BILE-DUCT-DESTRUCTION

ICD-10-PCS Code For Common Bile Duct: Procedure Code Group Overview

0F5D-PANCREATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Pancreatic Duct: Procedure Code Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview policy alerts

Ampulla Of Vater Destruction Procedure Overview

Code Attributes

ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview policy alerts

Ampulla Of Vater Destruction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 0F5C?

What are the code attributes for the 0F5C group?

Can you list the individual ICD-10-PCS codes in this group and their approaches?

How does accurate coding within 0F5C affect inpatient reimbursement?

Which DRGs are related to procedures in the 0F5C code group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in ICD-10-PCS code group 0F5C?

What are the code attributes for the 0F5C group?

Can you list the individual ICD-10-PCS codes in this group and their approaches?

How does accurate coding within 0F5C affect inpatient reimbursement?

Which DRGs are related to procedures in the 0F5C code group?

References