ICD-10-PCS Code For Liver: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 0F50 includes procedures performed to destroy tissues or portions of the liver in the hepatobiliary system and pancreas. These ICD-10-PCS codes are used for inpatient documentation when a clinician performs physical eradication of all or part of the liver using energy, force, or a destructive agent. Accurate coding within the ICD-10-PCS 0F50 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Liver Destruction Procedure Overview

This group includes inpatient procedures that physically destroy all or a portion of the liver using energy, force, or a destructive agent. These procedures target the hepatobiliary system and pancreas body system and involve intentional eradication of hepatic tissue. Accurate ICD-10-PCS coding matters for inpatient reimbursement because it documents the specific destructive technique and extent of tissue treated, which affects case mix and payment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
0	Section	Medical and Surgical
F	Body System	Hepatobiliary System and Pancreas
5	Operation	Destruction
0	Body Part	Liver

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ICD-10-PCS Code For Liver: Procedure Code Group Overview

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Liver Destruction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
0	Section	Medical and Surgical
F	Body System	Hepatobiliary System and Pancreas
5	Operation	Destruction
0	Body Part	Liver

When to Use

Use a code from this group when the clinical procedure intentionally destroys hepatic tissue rather than excises or removes it. Codes apply when the operative technique is destruction by energy, force, or a destructive agent and the target is the liver.

ICD-10-PCS Codes

9 rows

ICD-10-PCS Code	Description
0F500Z3	Destruction of Liver using Laser Interstitial Thermal Therapy, Open Approach
0F500ZF	Destruction of Liver using Irreversible Electroporation, Open Approach
0F500ZZ	Destruction of Liver, Open Approach
0F503Z3	Destruction of Liver using Laser Interstitial Thermal Therapy, Percutaneous Approach
0F503ZF	Destruction of Liver using Irreversible Electroporation, Percutaneous Approach
0F503ZZ	Destruction of Liver, Percutaneous Approach
0F504Z3	Destruction of Liver using Laser Interstitial Thermal Therapy, Percutaneous Endoscopic Approach
0F504ZF	Destruction of Liver using Irreversible Electroporation, Percutaneous Endoscopic Approach
0F504ZZ	Destruction of Liver, Percutaneous Endoscopic Approach

DRG Codes

9 rows

DRG Code	Description
356	Other Digestive System O.R. Procedures with MCC
357	Other Digestive System O.R. Procedures with CC
358	Other Digestive System O.R. Procedures without CC/MCC
405	Pancreas, Liver and Shunt Procedures with MCC
406	Pancreas, Liver and Shunt Procedures with CC
407	Pancreas, Liver and Shunt Procedures without CC/MCC
987	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with MCC
988	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with CC
989	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis without CC/MCC

Typical Clinical Scenarios

An adult patient presents with a solitary, small hepatocellular carcinoma deep in the right hepatic lobe identified on imaging and deemed unresectable due to inadequate future liver remnant. After multidisciplinary review, the team performs percutaneous thermal ablation under image guidance to destroy the tumor while preserving surrounding liver tissue; the intent is targeted destruction rather than excision. The procedure is performed percutaneously with laser interstitial thermal therapy to achieve tumor necrosis. Typical codes: 0F503Z3
An older patient with multiple metastases to the liver and rapidly progressive disease is admitted urgently for palliative control of a dominant lesion causing pain and local symptoms. Because surgical resection is not feasible, the interventional surgical team performs an open destruction of the symptomatic hepatic lesion using irreversible electroporation to ablate tumor tissue while minimizing thermal injury to adjacent structures. The goal is symptom relief through targeted destruction of hepatic tissue. Typical codes: 0F500ZF
A patient previously treated percutaneously for a hepatic tumor demonstrates recurrent disease at the treated site with irregular margins and adjacent biliary tract involvement. During a planned inpatient procedure, a percutaneous endoscopic approach is used to destroy the recurrent tumor tissue after direct visualization and access, choosing a non-thermal destructive method to preserve nearby bile ducts. The case represents treatment of recurrent hepatic disease requiring repeat destruction rather than formal resection. Typical codes: 0F504ZF, 0F504ZZ

Related Codes

0F51-LIVER-RIGHT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Right Lobe: Procedure Code Group Overview

0F52-LEFT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Left Lobe: Procedure Code Group Overview

0F54-GALLBLADDER-DESTRUCTION

ICD-10-PCS Code For Gallbladder: Procedure Code Group Overview

0F55-HEPATIC-DUCT-RIGHT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Right: Procedure Code Group Overview

0F56-LEFT-HEPATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct, Left: Procedure Code Group Overview

0F57-HEPATIC-DUCT-COMMON-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Common: Procedure Code Group Overview

0F58-CYSTIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Cystic Duct: Procedure Code Group Overview

0F59-COMMON-BILE-DUCT-DESTRUCTION

ICD-10-PCS Code For Common Bile Duct: Procedure Code Group Overview

0F5C-AMPULLA-OF-VATER-DESTRUCTION

ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview

0F5D-PANCREATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Pancreatic Duct: Procedure Code Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

9 rows

ICD-10-PCS Code	Description
0F500Z3	Destruction of Liver using Laser Interstitial Thermal Therapy, Open Approach
0F500ZF	Destruction of Liver using Irreversible Electroporation, Open Approach
0F500ZZ	Destruction of Liver, Open Approach
0F503Z3	Destruction of Liver using Laser Interstitial Thermal Therapy, Percutaneous Approach
0F503ZF	Destruction of Liver using Irreversible Electroporation, Percutaneous Approach
0F503ZZ	Destruction of Liver, Percutaneous Approach
0F504Z3	Destruction of Liver using Laser Interstitial Thermal Therapy, Percutaneous Endoscopic Approach
0F504ZF	Destruction of Liver using Irreversible Electroporation, Percutaneous Endoscopic Approach
0F504ZZ	Destruction of Liver, Percutaneous Endoscopic Approach

DRG Codes

9 rows

DRG Code	Description
356	Other Digestive System O.R. Procedures with MCC
357	Other Digestive System O.R. Procedures with CC
358	Other Digestive System O.R. Procedures without CC/MCC
405	Pancreas, Liver and Shunt Procedures with MCC
406	Pancreas, Liver and Shunt Procedures with CC
407	Pancreas, Liver and Shunt Procedures without CC/MCC
987	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with MCC
988	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis with CC
989	Non-Extensive O.R. Procedures Unrelated to Principal Diagnosis without CC/MCC

Typical Clinical Scenarios

An adult patient presents with a solitary, small hepatocellular carcinoma deep in the right hepatic lobe identified on imaging and deemed unresectable due to inadequate future liver remnant. After multidisciplinary review, the team performs percutaneous thermal ablation under image guidance to destroy the tumor while preserving surrounding liver tissue; the intent is targeted destruction rather than excision. The procedure is performed percutaneously with laser interstitial thermal therapy to achieve tumor necrosis. Typical codes: 0F503Z3
An older patient with multiple metastases to the liver and rapidly progressive disease is admitted urgently for palliative control of a dominant lesion causing pain and local symptoms. Because surgical resection is not feasible, the interventional surgical team performs an open destruction of the symptomatic hepatic lesion using irreversible electroporation to ablate tumor tissue while minimizing thermal injury to adjacent structures. The goal is symptom relief through targeted destruction of hepatic tissue. Typical codes: 0F500ZF
A patient previously treated percutaneously for a hepatic tumor demonstrates recurrent disease at the treated site with irregular margins and adjacent biliary tract involvement. During a planned inpatient procedure, a percutaneous endoscopic approach is used to destroy the recurrent tumor tissue after direct visualization and access, choosing a non-thermal destructive method to preserve nearby bile ducts. The case represents treatment of recurrent hepatic disease requiring repeat destruction rather than formal resection. Typical codes: 0F504ZF, 0F504ZZ

Related Codes

0F51-LIVER-RIGHT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Right Lobe: Procedure Code Group Overview

0F52-LEFT-LOBE-DESTRUCTION

ICD-10-PCS Code For Liver Left Lobe: Procedure Code Group Overview

0F54-GALLBLADDER-DESTRUCTION

ICD-10-PCS Code For Gallbladder: Procedure Code Group Overview

0F55-HEPATIC-DUCT-RIGHT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Right: Procedure Code Group Overview

0F56-LEFT-HEPATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct, Left: Procedure Code Group Overview

0F57-HEPATIC-DUCT-COMMON-DESTRUCTION

ICD-10-PCS Code For Hepatic Duct Common: Procedure Code Group Overview

0F58-CYSTIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Cystic Duct: Procedure Code Group Overview

0F59-COMMON-BILE-DUCT-DESTRUCTION

ICD-10-PCS Code For Common Bile Duct: Procedure Code Group Overview

0F5C-AMPULLA-OF-VATER-DESTRUCTION

ICD-10-PCS Code For Ampulla Of Vater: Procedure Code Group Overview

0F5D-PANCREATIC-DUCT-DESTRUCTION

ICD-10-PCS Code For Pancreatic Duct: Procedure Code Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Liver: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Liver: Procedure Code Group Overview policy alerts

Liver Destruction Procedure Overview

Code Attributes

ICD-10-PCS Code For Liver: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Liver: Procedure Code Group Overview policy alerts

Liver Destruction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which body system and operation does ICD-10-PCS code group 0F50 describe?

What approaches and techniques are represented within the 0F50 code group?

How should accurate coding within the 0F50 group be used in inpatient documentation?

Which DRG families can be related to procedures coded from the 0F50 group?

What are examples of individual ICD-10-PCS codes included in the 0F50 group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which body system and operation does ICD-10-PCS code group 0F50 describe?

What approaches and techniques are represented within the 0F50 code group?

How should accurate coding within the 0F50 group be used in inpatient documentation?

Which DRG families can be related to procedures coded from the 0F50 group?

What are examples of individual ICD-10-PCS codes included in the 0F50 group?

References