Prior authorization and utilization management for specialty and injectable drugs and selected services
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Defines authorization pathways and UM program assignments for specialty/injectable drugs and selected services for Highmark BlueShield members in specified states; informs providers how to determine plan-specific authorization requirements.
No material clinical or coverage changes in this revision.
Coverage Criteria and Management Assignment
Management assignment (Evolent vs Highmark)
Coverage/management assignment is presented as mappings; coverage decisions depend on matching the drug name, J-code, and diagnosis to the listed manager.
Providers must use the specific mapping lines to determine the correct UM manager and prior authorization pathway.
Program management assignment (Evolent vs Highmark)
Coverage/management assignment by diagnosis and J-code
Mapping of specific drugs/J-codes to Evolent or Highmark is provided alongside each listed agent in this section.
Management assignment criteria
Coverage and management assignment by drug/code and diagnosis/site-of-care
Providers must include the exact J‑/Q‑code, drug name, diagnosis and site‑of‑care on UM/prior authorization requests to route to the correct manager.
UM routing by diagnosis and code
Routing and management criteria by diagnosis and service
Applies to codes and services listed throughout chunks 234–253; QMR and many device/supply codes are routed to Highmark Management Services or Highmark Advanced Imaging as indicated.
Services listed under the Evolent Oncology UM Program are managed by Evolent for most cancer diagnoses; services for all other (non-cancer) diagnoses are managed by Highmark. Providers should use the program mapping on the J‑code / CPT / HCPCS line items to determine which UM program (Evolent vs Highmark) will handle prior authorization and utilization management for a given service.
This excerpt contains no additional clinical exclusion statements. It reiterates the administrative program assignment: when a diagnosis maps to the Evolent Oncology UM Program the service is managed by Evolent; when the diagnosis is not an Evolent‑managed cancer diagnosis, Highmark manages the service.
For oncology diagnoses the document assigns management to the Evolent Oncology UM Program. When the submitted diagnosis is a cancer diagnosis falling within the Evolent program mapping, prior authorization and UM for the associated oncology services and injectables will be routed to Evolent per the code‑to‑program mapping.
For non‑cancer diagnoses the utilization management responsibility rests with Highmark. Services that do not meet the Evolent oncology diagnosis mapping should be routed to Highmark for prior authorization and UM processing.
This partial segment does not list any explicit clinical exclusions (for example, specific procedures labeled 'not medically necessary'). The content is administrative in nature and focuses on mapping J‑codes and other codes to the managing entity rather than setting clinical exclusion rules.
Management assignment is driven by the combination of the submitted code (J‑code, Q‑code, CPT/HCPCS) and the patient diagnosis: if the diagnosis corresponds to an Evolent‑managed oncology entry, the request is managed by Evolent; otherwise Highmark manages the request. The excerpt contains no stand‑alone clinical exclusion criteria; use the code‑to‑program mappings to determine routing.
This portion is primarily an administrative mapping of procedure, device and supply codes to the managing entity. It indicates which codes are routed to Highmark Management Services and which diagnoses (primarily cancer diagnoses) are routed to Evolent, without adding independent clinical rules in the excerpt.
Within the PET imaging code list the entry G0219 is noted as ‘PET IMAGING WHOLE BODY; MELANOMA FOR NON‑COVERED INDICATIONS’. This indicates a specific non‑covered use case is identified for that PET melanoma entry in the code mapping provided.
Evolent manages services only for the diagnoses that are explicitly listed as Evolent‑managed in the mapping; all other diagnoses (i.e., diagnoses not mapped to Evolent) are managed by Highmark. Providers must submit the correct procedure/J‑code and diagnosis so the request is routed to the appropriate manager.
The document reiterates the program split: services for most cancer diagnoses are managed by the Evolent Oncology UM Program, and services for non‑oncology diagnoses are managed by Highmark. The excerpt does not provide further clinical limitations or 'not medically necessary' statements.
No explicit 'not medically necessary' determinations are stated in this small excerpt. The content focuses on administrative mapping and program assignment rather than defining clinical coverage denials.
This partial section contains no explicit 'not medically necessary' language. It enumerates J‑codes and associated agents and indicates program assignment (Evolent, Highmark or both) rather than defining clinical exclusions.
No 'not medically necessary' statements appear in this excerpt. The listed entries describe mapping of other specialty drug J‑codes to Highmark Specialty or Evolent as appropriate, without introducing clinical exclusion criteria in this fragment.
CPT / HCPCS / J-code & Device Code Lists
| H0032 | MENTAL HEALTH SERVICE PLAN DEVELOPMENT BY NON-PHYSICIAN |
| H2019 | THERAPEUTIC BEHAVIORAL SERVICES, PER 15 MINUTES |
| H0015 | ALCOHOL AND/OR DRUG SERVICES; INTENSIVE OUTPATIENT TREATMENT |
| S9480 | INTENSIVE OUTPATIENT PSYCHIATRIC SERVICES, PER DIEM |
| H0035 | INTENSIVE OUTPATIENT PSYCHIATRIC SERVICES, PER DIEM |
| S0201 | PARTIAL HOSPITALIZATION SERVICES, LESS THAN 24 HOURS, PER DIEM |
| 90868 | TRANSCRANIAL MAGNETIC STIMULATION (TMS) THERAPEUTIC REPETITIVE TMS |
| 90869 | TMS MOTOR THRESHOLD RE-DETERMINATION WITH DELIVERY AND MANAGEMENT |
| H0019 | BEHAVIORAL HEALTH; LONG-TERM RESIDENTIAL, PER DIEM |
| T2048 | BEHAVIORAL HEALTH; LONG-TERM CARE RESIDENTIAL, PER DIEM |
| 0362T | TMS-RELATED / SITE SPECIFIC (temporary placeholder) |
| 0373T | TMS-RELATED / SITE SPECIFIC (temporary placeholder) |
| 97151 | ASSESSMENT/PLAN DEVELOPMENT BY CERTIFIED BEHAVIOR ANALYST, FIRST 15 MIN |
| 97152 | BEHAVIOR IDENTIFICATION ASSESSMENT, EACH 15 MIN |
| 97153 | BEHAVIORAL TREATMENT, PARENT TRAINING, FAMILY-RELATED |
| 97154 | ADAPTIVE BEHAVIOR TREATMENT BY TECHNICIAN |
| 97155 | ADAPTIVE BEHAVIOR TREATMENT SUPERVISION BY BCBA |
| 97156 | FAMILY ADAPTIVE BEHAVIOR TREATMENT, EACH 15 MIN |
| 97157 | FAMILY ADAPTIVE BEHAVIOR TREATMENT, MODIFICATION |
| 97158 | GROUP ADAPTIVE BEHAVIOR TREATMENT |
| 43644 | LAPAROSCOPY, GASTRIC BYPASS WITH ROUX-EN-Y (<=150 cm) |
| 43645 | LAPAROSCOPY, GASTRIC BYPASS WITH SMALL INTESTINE RECONSTRUCTION |
| 43647 | LAPAROSCOPY, IMPLANTATION/REPLACEMENT OF GASTRIC NEUROSTIMULATOR ELECTRODES, ANTRUM |
| 43771 | LAPAROSCOPIC REVISION OF ADJUSTABLE GASTRIC RESTRICTIVE DEVICE COMPONENT |
| 43773 | LAPAROSCOPY, REMOVAL/REPLACEMENT OF ADJUSTABLE GASTRIC RESTRICTIVE DEVICE COMPONENT |
| 43774 | LAPAROSCOPY, REMOVAL OF ADJUSTABLE GASTRIC RESTRICTIVE DEVICE & PORT |
| 43775 | LAPAROSCOPY, SLEEVE GASTRECTOMY |
| 43843 | GASTRIC RESTRICTIVE PROCEDURE, OTHER THAN VERTICAL-BANDED GASTROPLASTY |
| 43845 | BILIOPANCREATIC DIVERSION WITH DUODENAL SWITCH |
| 43847 | GASTRIC RESTRICTIVE PROCEDURE WITH GASTRIC BYPASS; SHORT LIMB ROUX-EN-Y |
| E0747 | OSTEOGENESIS STIMULATOR, ELECTRICAL, NON-INVASIVE (OTHER THAN SPINAL) |
| E0760 | OSTEOGENESIS STIMULATOR, LOW INTENSITY ULTRASOUND, NON-INVASIVE |
| 91110 | GASTROINTESTINAL TRACT IMAGING, INTRALUMINAL (CAPSULE ENDOSCOPY), INTERPRETATION & REPORT (ESOPHAGUS THROUGH ILEUM) |
| 91111 | CAPSULE ENDOSCOPY, WITH INTERPRETATION AND REPORT (ESOPHAGUS) |
| 33206 | Insertion of new or replacement permanent pacemaker with transvenous electrode(s); atrial |
| 33207 | ...; ventricular |
| 33208 | ...; atrial and ventricular |
| 33214 | Upgrade of implanted pacemaker system to dual chamber (includes generator removal, testing, insertion) |
| 33216 | Insertion of a single transvenous electrode, pacemaker or implantable defibrillator |
| 33217 | Insertion of 2 transvenous electrodes, pacemaker or implantable defibrillator |
| 33224 | Insertion of pacing electrode, cardiac venous system, for LV pacing, with attachment to existing generator |
| 33227 | Removal of pacemaker pulse generator with replacement; single lead |
| 33228 | Removal/replacement; dual lead |
| 33229 | Removal/replacement; multiple lead system |
| 75571 | CT, heart, without contrast, with quantitative coronary calcium |
| 75572 | CT, heart, with contrast for evaluation of cardiac structure and morphology |
| 75573 | CT, heart with contrast for congenital heart disease (includes 3D postprocessing) |
| 75574 | CT angiography, heart, coronary arteries and bypass grafts, with contrast and 3D postprocessing |
| 0331T | Myocardial sympathetic innervation imaging, planar and tomographic SPECT mapping (cross-mapped) |
| 0332T | Tomographic SPECT assessment variant |
| 33340 | Percutaneous transcatheter closure of the left atrial appendage with endocardial implant |
| 33361 | TAVR percutaneous femoral artery approach |
| 33362 | TAVR open femoral artery approach |
| 33363 | TAVR open axillary artery approach |
| 34709 | Placement of extension prosthesis distal to common iliac or proximal to renal artery for EVAR |
| 34710 | Delayed placement of extension prosthesis for EVAR |
| 34711 | Each additional vessel treated (listed separately) |
| 34712 | Transcatheter delivery of enhanced fixation device to endograft |
| 92920 | PTCA; single major coronary artery or branch |
| 92928 | Placement of intracoronary stent(s) with PTCA; single major coronary artery |
| 92937 | PTCA of or through coronary artery bypass graft |
| 92943 | Coronary thrombectomy (when performed) |
| 93580 | Invasive hemodynamic monitoring procedures (example cross-mapped) |
| 0408T | Insertion/replacement of permanent cardiac contractility modulation system, pulse generator only |
| 66989 | Complex extracapsular cataract removal with IOL, complex techniques or devices |
| 66991 | Cataract removal with insertion of IOL and anterior segment aqueous drainage device |
| 75557 | Cardiac MRI without contrast, morphology and function |
| 75559 | CMRI with stress imaging |
| 75561 | CMRI with contrast sequences |
| 75563 | CMRI with contrast and stress |
| 75565 | CMRI velocity flow mapping |
| 69714 | Implantation, osseointegrated implant, temporal bone (listening device) |
| 69930 | Cochlear implant insertion |
| L8614 | Cochlear device internal and external components |
| 61863 | Stereotactic implantation of neurostimulator electrode array, twist drill/burr hole (first array) |
| 61867 | ... with intraoperative microelectrode recording |
| 70450 | CT head without contrast |
| 70460 | CT head with contrast |
| 70470 | CT head without & with contrast |
| 70480 | CT orbit without contrast |
| 70481 | CT orbit with contrast |
| 70482 | CT orbit without & with contrast |
| 70486 | CT maxillofacial without contrast |
| 70487 | CT maxillofacial with contrast |
| 71250 | CT thorax without contrast |
| 71260 | CT thorax with contrast |
| 71270 | CT thorax without & with contrast |
| 72125 | CT cervical spine without contrast |
| 72126 | CT cervical spine with contrast |
| 72127 | CT cervical spine without & with contrast |
| 72128 | CT thoracic spine without contrast |
| 72129 | CT thoracic spine with contrast |
| 72130 | CT thoracic spine without & with contrast |
| 72131 | CT lumbar spine without contrast |
| 76380 | CT limited or localized follow-up study |
| 0711T | CTA noninvasive arterial plaque analysis (data prep/transmission) |
| 0712T | CTA noninvasive arterial plaque analysis (quantification) |
| 0713T | CTA plaque analysis interpretation & report |
| 93319 | 3D echocardiographic imaging and postprocessing during TEE or TTE for congenital anomalies |
| 93350 | Echocardiography, transthoracic, real-time with image documentation (2D) |
| 93351 | Echocardiography TTE with MMODE during stress |
| 0648T | Quantitative magnetic resonance for single organ (QMR) |
| 0649T | QMR obtained with diagnostic MRI of same anatomy |
| 0697T | QMR multiple organs without diagnostic MRI |
What Providers Must Do
How to verify authorization
Providers must verify member-specific authorization requirements before submitting any prior authorization (PA) or utilization management (UM) request. Check the phone number on the back of the member’s ID card, confirm eligibility and benefits via Availity, or search BlueExchange® through the provider portal to determine whether PA is required for the member’s plan.
- How to verify authorization: call the number on the back of the member's card; check Availity eligibility/benefits; search BlueExchange through local provider portal.
Prior authorization / utilization management routing
Prior authorization and UM routing are code- and diagnosis-dependent. Many procedures and drugs in the code lists are designated either Highmark Management Services, Highmark Advanced Imaging, Highmark Specialty/Site-of-Care, or Evolent (Evolent Oncology UM Program). Submit the exact CPT/HCPCS/J-/Q-code and the member’s diagnosis on the request so the service is routed to the correct manager.
- Many listed procedures are designated as Highmark Management Services, Highmark Advanced Imaging, Highmark Specialty (including Site of Care), or Evolent Oncology — use the code-to-program mapping when requesting UM review.
- Procedure code and diagnosis routing: include the CPT/HCPCS/J-/Q-code and indicate whether the diagnosis is cancer-related to ensure routing to Evolent Oncology UM Program (Evolent) or Highmark as specified.
- Use code-to-program mapping for routing: follow the management designation shown next to each listed code when submitting PA/UM requests.
J-code-based UM assignment
Certain injectable specialty and oncology drugs are assigned to a specific UM program. For drugs listed with J- or Q-codes, providers must include the drug name and the exact HCPCS/J-/Q-code on the prior authorization or UM submission. Management responsibility often depends on diagnosis (Evolent for most cancer diagnoses; Highmark for non-oncology or other specialty assignments).
- J-code-based UM assignment: prior authorization/UM management is designated per listed J/Q codes and associated drug names; include the J-/Q-code and drug name on the request.
- Include specific drug and J-code information: list the exact drug and corresponding J-/Q-code on PA/UM requests.
- Include correct J-code and drug name to ensure accurate routing and adjudication.
- Submit correct code and site-of-care when applicable (site-of-care designations are shown for some oncology/site-of-care drugs).
- Use specific J-/Q-code for routing: management assignment (Evolent vs Highmark) is determined by the code and diagnosis.
MRI/MRA prior authorization routing
Prior authorization is required for many MRI/MRA/QMR services designated as Highmark Advanced Imaging (some are Gold Card Eligible). When requesting prior authorization for MRI/MRA/QMR procedures, reference the exact CPT/HCPCS/QMR code and route the request to Highmark Advanced Imaging as indicated.
- MRI/MRA prior authorization routing: many MRI and MRA CPT/HCPCS codes (for example 70549, 70551, 73718–73723, 74181–74183, 0610T–0612T, S8037, S8042) are designated Highmark Advanced Imaging.
- QMR codes (0649T, 0697T, 0698T) and other quantitative MRI codes are routed to Highmark Advanced Imaging.
- Gold Card Eligible: some advanced imaging codes are marked Gold Card Eligible — follow plan-specific Gold Card rules where applicable.
Prior authorization required for select therapy codes
Certain therapy and rehabilitation codes require prior authorization when routed to Highmark Physical Medicine/Highmark Physical. Include the therapy CPT code(s) and relevant clinical rationale when submitting PA/UM requests.
- Prior authorization required for select therapy codes effective 2/1/2020: OT codes 97129, 97130 and physical/therapy codes 97139, 97164 require prior authorization.
- Physical Medicine routing: these therapy codes are managed by Highmark Physical Medicine / Highmark Physical.
- When submitting UM requests for therapy codes, include the primary procedure code, therapy code(s), clinical rationale, and number of units/sessions.
Prior authorization routing and required codes
Certain device, powered vehicle, and accessory codes are managed by Highmark Management Services and require the proper procedure or supply code on UM/PA submissions. Include model/brand details when applicable.
- Each listed powered vehicle and accessory code (for example E1230, E1239, E2298, E2324, E2327, K0011, K0012, K0014, K0098, K0800–K0899, K0884–K0891, K0898–K0899) is managed by Highmark Management Services.
- Required coding on UM requests: include the applicable HCPCS/CPT/L-code (e.g., K0884, K0885, L1840, L3971, L6647, 0648T, 0649T, 0697T, 0698T, etc.) and device model/brand when requested.
- Coding documentation guidance: for QMR/QMR-related and reconstructive/cosmetic codes, include the primary procedure, clinical rationale, and any QMR code details on the request.
Program assignment and routing impact
Management assignment affects authorization routing and may impact timeliness of review. Services in the Evolent Oncology UM Program are managed by Evolent for most cancer diagnoses and by Highmark for other diagnoses; submitting to the wrong manager can delay or jeopardize authorization.
- Program routing for oncology vs non-oncology diagnoses: for items listed under the Evolent Oncology UM Program, indicate whether the diagnosis is cancer-related — Evolent manages most cancer diagnoses; Highmark manages non-cancer diagnoses.
- Management routing affects authorization: incorrect routing (e.g., sending an oncology cancer diagnosis case to Highmark instead of Evolent) may cause delayed review or denial risk.
- When in doubt, include the diagnosis and the specific code on the request to ensure correct routing to Evolent or Highmark.
What to include on UM/PA requests
When submitting prior authorization or UM requests: include the exact CPT/HCPCS/J-/Q-code, the associated drug name (for injectables), the member’s diagnosis, the site of care (if applicable), and the clinical rationale. This ensures the request is routed to the correct program (Evolent Oncology UM Program, Highmark Management Services, Highmark Advanced Imaging, Highmark Specialty, or Highmark Site of Care) and reduces the risk of delays or denials.
- Code-specific routing requirement: prior authorization or UM submissions must reference the exact procedure or HCPCS/J-/Q-code to route the service to the designated manager.
- Include correct J-code and drug name and submit correct code and site-of-care when applicable.
- Use code-to-program mapping and indicate the diagnosis (oncology vs non-oncology) to direct the request to Evolent or the appropriate Highmark program.
Site-of-Care Designations
Step Therapy and Sequencing Notes
| Initial therapy criteria | Notes |
|---|---|
| No top-level initial therapy criteria specified in this partial section. | The document lists program-level management assignments for listed J-codes and drugs but does not define initial therapy requirements or clinical start criteria in the excerpt provided. |
| 0 top-level nodes | See UM program mappings for management routing; clinical initial-therapy rules are not present in this fragment. |
| Step therapy sequencing present? | Summary |
|---|---|
| No explicit step therapy sequence described in this partial section. | The excerpt states that no explicit step therapy requirements are specified here; prior authorization and UM routing are determined by J-code and diagnosis mapping. |
| Agent-specific authorization required when codes map multiple agents | Explanation / Example |
|---|---|
| Yes — agent-specific prior authorization criteria apply when multiple agents share a site-code grouping. | Entries show J9173 grouped to multiple agents (e.g., durvalumab mapped to nivolumab, pembrolizumab, combinations) and are labeled Evolent*/Highmark — providers must apply agent-specific prior authorization even when codes share a site-of-care grouping. |
| Step therapy rules provided in excerpt | Notes |
|---|---|
| No — no step therapy rules are provided in this excerpt. | The document indicates prior authorization and UM program assignment by J-/Q-code and diagnosis, but explicit step therapy algorithms or required prior agents are not defined in the provided sections. |
Biosimilar & Originator Product Notes
Background
Background: this document segment lists specialty and injectable drugs, procedure and supply codes, and maps each code or drug entry to a utilization management program. The mapping establishes that the Evolent Oncology UM Program manages utilization for most cancer diagnoses while Highmark manages services for other diagnoses and many non‑oncology specialty drugs and device codes.
Definitions and Designations
Revision History
OpenPayer is powered by Trek Health's payer performance platform. Trek continuously ingests, validates, and normalizes Transparency in Coverage data alongside payer policies and other commercial payer data to create a structured payer intelligence foundation. OpenPayer uses this foundation to deliver personalized search results, dynamically generated policy pages, and tailored policy monitoring based on each user's payers, specialties, billing codes, and areas of interest. The same intelligence powers broader payer performance workflows, including reimbursement benchmarking, contract evaluation, payer negotiations, and financial decision-making.