Provider Administered Drug Program (PADP) — Prior Authorization and PADP Drug List
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Defines the Provider Administered Drug Program (PADP) managed by Prime Therapeutics (Magellan Rx Management) for Florida Blue and Health Options, specifying which provider settings, member products, and HCPCS/J-codes require prior authorization and are managed under the program.
No material clinical or coverage changes in this revision.
Coverage Criteria
The following member products, provider types and benefit arrangements are excluded from MRxM (PADP) management: Medicare Part B Primary, FEP (Federal Employee Program), BlueCard Host, Be Healthy, Medicare Advantage HMO & PPO, Medicare Supplement, and CareCentrix providers when services are In‑State Home or Ambulatory Infusion Suite (AIS) (CareCentrix will perform prior authorization for those CareCentrix cases). In addition, drugs that are covered and processed through the Pharmacy Benefit (PBM or Part D) are not managed by MRxM. Providers participating in Florida Blue PADP should confirm whether the member’s benefit arrangement places the drug under PADP or routes prior authorization elsewhere prior to administration.
When billing with unclassified/unspecified HCPCS, note that drugs associated to J9999 are NOT accepted with C9399. Per the PADP guidance, Magellan Rx Management (MRxM) authorizations will not be applied when claims are billed with C9399. Ensure the correct HCPCS is used—once CMS assigns a permanent HCPCS to a product it will be added to the PADP Drug List and managed through MRxM.
HCPCS / J-code Lists
| A9513 | LUTETIUM LU 177 |
| A9543 | IBRITUMOMAB TIUXETAN |
| A9590 | IODINE I-131 IOBENGUANE |
| A9600 | STRONTIUM SR-89 CHLORIDE |
| A9604 | SAMARIUM SM-153 LEXIDRONAM |
| A9606 | RADIUM RA223 DICHLORIDE THER |
| A9607 | LUTETIUM (177LU) VIPIVOTIDE TETRAXETAN |
| A9699 | UNCLASSIFIED RADIOPHARMACEUTICAL |
| J0013 | ESKETAMINE (SPRAVATO) |
| J0129 | ABATACEPT (ORENCIA IV) |
| J1439 | INJECTAFER / FERRIC CARBOXYMALTOSE |
| J1440 | REBYOTA / FECAL MICROBIOTA, LIVE-JSLM |
| J1442 | NEUPOGEN / FILGRASTIM |
| J1447 | GRANIX / TBO-FILGRASTIM |
| J1448 | COSELA / TRILACICLIB |
| J1449 | ROLVEDON / EFLAPEGRASTIM-XNST |
| J1453 | EMEND / FOSAPREPITANT |
| J1454 | AKYNZEO / FOSNETUPITANT & PALONOSE |
| J1458 | NAGLAZYME / GALSULFASE |
| J1459 | PRIVIGEN / HUMAN IMMUNE GLOBULIN |
| J7324 | HIGH MOLECULAR WEIGHT HYALURONAN INJECTION |
| J7325 | HYLAN G-F 20 (SYNVISC / SYNVISC ONE) |
| J7326 | CROSS-LINKED HYALURONATE (GEL-ONE) |
| J7327 | HIGH MOLECULAR WEIGHT HYALURONAN (MONOVISC) |
| J7328 | HYALURONAN/DERIVATIVE (GEL-SYN) |
| J7329 | HYALURONAN/DERIVATIVE (TRIVISC) |
| J7331 | SYNOJOYNE (SYNOJOYT) |
| J7332 | TRILURON |
| J7352 | AFAMELANOTIDE (SCENESSE) |
| J7354 | CANTHARIDIN (YCANTH) |
| J9314 | |
| J9316 | PHESGO; PERTUZUMAB, TRASTUZUMAB, and HYALURONIDASE-ZZXF |
| J9317 | TRODELVY; SACITUZUMAB GOVITECAN-HZIY |
| J9318 | ROMIDEPSIN, non-lyophilied |
| J9319 | ISTODAX; ROMIDEPSIN, lyophilied |
| J9321 | EPKINLY; EPCORITAMAB-BYSP |
| J9322 | PEMETREXED |
| J9323 | PEMETREXED |
| J9324 | PEMYRDI RTU / PEMETREXED |
| J9325 | IMLYGIC; TALIMOGENE LAHERPAREPVEC |
| J3590 | Unclassified drug/biological |
| J9999 | Not otherwise classified drugs (J9999 used as unspecified) |
| J1599 | Unclassified drugs — immune globulin IV referenced |
| J3402 | New HCPCS effective 10/01/2025 referenced for remestemcel-L-RKND |
| J9184 | Gemcitabine — new HCPCS reference (effective 01/01/2026) for AVGEMSI |
| J9256 | Nipocalimab — new HCPCS reference (effective 01/01/2026) for IMAAVY |
| J9282 | Mitomycin — new HCPCS reference (effective 01/01/2026) for ZUSDURI |
| J9011 | Datopotamab deruxtecan — new HCPCS reference (effective 10/01/2025) for DATROWAY |
| Q5160 | New Q-code referenced for bevacizumab biosimilar (effective 01/01/2026) |
| Q5154 | New Q-code referenced for omalizumab (effective 10/01/2025) |
Provider Actions & Billing Rules
Prior Authorization Required
Providers must obtain prior authorization for physician-administered drugs listed on the PADP Drug List (including drugs billed to unclassified/NOC HCPCS) before administration. Claims for listed HCPCS/J/Q codes submitted without required prior authorization may be denied and payment withheld; the member cannot be held responsible for charges denied due to missing authorization.
- Prior authorization is required for all PADP-listed HCPCS/J/Q codes and associated drug products prior to service.
- If a prior authorization is not obtained as required by the member benefit arrangement, payment for the service may be denied.
- Providers participating in Florida Blue Utilization Management Programs (PADP) must request prior authorization through Magellan Rx Management (Prime Therapeutics Management MPS division).
PADP Unclassified HCPCS Drugs — Prior Authorization Required
PADP includes a list of specifically coded HCPCS/J/Q drugs and a list of drugs currently billed to unclassified or NOC codes (for example J9999, J1599, J3590, A9699, Q9999). Prior authorization is required for both specifically listed HCPCS codes and those on the PADP Unclassified HCPCS Drug List.
Documentation Expectations for Prior Authorization
Document clinical rationale and supporting medical records when submitting prior authorization requests. Include diagnosis, prior treatments, relevant labs/imaging, and planned administration details (dose, frequency, place of service).
- Documentation supporting medical necessity must be available for review and may be required to complete the PADP prior authorization.
- When member product requires a specialist referral or home nursing prior authorization, these are reviewed separately by Florida Blue per normal processes.
Unclassified HCPCS / HCPCS Assignment & Billing Guidance
Billing and coding guidance for NOC/unclassified and newly assigned HCPCS: continue to bill using the applicable unclassified/NOC HCPCS (J9999, J1599, J3590, A9699, etc.) for products not yet assigned a permanent HCPCS. Once CMS assigns a permanent HCPCS to a drug previously billed to an unspecified/NOC code, the new HCPCS will be included in the PADP Drug List and managed by Magellan Rx Management.
- Do not bill drugs associated to J9999 with C9399; MRxM authorizations will not be applied when billing C9399.
- C-codes are billable only in the Hospital Outpatient setting for specified drugs; other settings must use the unspecified drug HCPCS until a permanent HCPCS is assigned by CMS.
- When a new permanent HCPCS is assigned, the permanent code will be added to the PADP Drug List and prior authorization requirements will follow that listing.
Benefit-Arrangement Based Requirements
Prior authorization requirements depend on the member benefit arrangement and provider contract. Some member products require prior authorization for PADP drugs (see PADP member benefit lists); others may be eligible for a Voluntary Predetermination of Select Services (VPSS). Verify the member's product and applicable provider arrangement before administering drugs.
- Member benefit arrangements that require prior authorization include BlueCare HMO, SimplyBlue, My Blue (prior auth in addition to referral when applicable), BlueSelect, BlueOptions ACA/CE, and BlueChoice where applicable.
- If a provider contract or member arrangement does not require prior authorization, providers may request a VPSS for PADP drugs; VPSS reviews for PADP drugs are performed by Prime Therapeutics Management MPS division.
- A separate authorization for administration/per diem services is not required when the member product requires prior authorization for the drug unless specifically identified.
Background
The Provider Administered Drug Program (PADP) utilization management program is intended to ensure proposed provider‑administered medications meet medical necessity under the member’s benefit plan and to manage utilization for select physician/healthcare professional administered medications. PADP has been managed by Prime Therapeutics Management (formerly Magellan Rx Management) since July 2009. Participating Florida Blue providers are required to obtain prior authorization for PADP‑listed drugs before administration; claims for PADP drugs submitted without required prior authorization may be denied and the member cannot be held responsible for denied charges.
Definitions
Site of Care Applicability
Obtain PA for PADP drugs in outpatient settings
PADP prior authorization and management apply when drugs are administered in outpatient settings (on‑ and off‑campus), ambulatory surgery centers, home, clinics, offices, ambulatory infusion suites (AIS), and other outpatient centers; ensure PA is obtained for services in these settings.
Use C‑codes only in Hospital Outpatient when allowed
C‑codes are only billable for the specified drug services within the Hospital Outpatient setting; other settings must bill with the corresponding unspecified drug HCPCS until CMS assigns a listed HCPCS.
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