HCPCS J1448: Injection, trilaciclib, 1mg

HCPCS Level II code J1448 describes a 1 mg injectable dose of trilaciclib, used as an intravenous pharmacologic agent to protect bone marrow during cytotoxic chemotherapy; service type: injection/infusion medication administration; typical site of service: hospital outpatient infusion center or oncology clinic.

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HCPCS J1448: Injection, trilaciclib, 1mg

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Get alerted when payer policies referencing J1448 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical patient is an adult receiving myelotoxic chemotherapy for extensive-stage small cell lung cancer or another malignancy where prophylactic myeloprotection is indicated. The oncology clinic schedules J1448 (injection, trilaciclib, 1 mg) to be administered intravenously prior to cytotoxic chemotherapy on the day of treatment. The workflow includes verification of the chemotherapy order, review of current blood counts and infusion history, confirmation of indications and consent, preparation of the appropriate trilaciclib dose by pharmacy, and administration by an infusion nurse or oncology-trained clinician in an outpatient infusion center or hospital oncology unit. Vital signs and pre-infusion assessment are completed, the drug is infused per protocol before the cytotoxic agent, and the patient is monitored for immediate adverse reactions. Documentation includes the drug name and J1448 HCPCS code, NDC or lot number if required by payer, dose administered (in mg), route (intravenous), start and stop times, applicable modifier(s), and associated ICD-10 diagnosis that supports medical necessity for myeloprotection during chemotherapy.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, infusion technique, up to 1 hour, single or initial substance/drug	Commonly performed immediately after `J1448` when trilaciclib is given prior to chemotherapy; documents the administration of the cytotoxic agent
`96415`	Chemotherapy administration, each additional hour (list separately in addition to code for primary infusion)	Used when chemotherapy infusion extends beyond the initial hour following trilaciclib premedication
`96417`	Chemotherapy administration, each additional sequential infusion of a new drug, up to 1 hour	Applicable when multiple sequential IV chemotherapeutic agents are administered after trilaciclib
`96360`	Intravenous infusion, hydration; initial, 31 minutes to 1 hour	May be billed when IV hydration is provided alongside trilaciclib and chemotherapy
`96374`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intravenous push, single or initial substance	For facilities that bill an injection code for drug administration technique when applicable

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
33	Modifier 33 was created by the American Medical Association in response to the Affordable Care Act to identify services provided for preventive intent. It is appended to CPT/HCPCS codes that could be…	- Use modifier -33 when a CPT/HCPCS service that can be billed as either preventive or diagnostic/treatment is provided with preventive intent and aligns with USPSTF A or B recommendations or other…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
363LA2200X	Adult Health Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
242T00000X	Perfusionist	A perfusionist operates extracorporeal circulation and autotransfusion equipment during any medical situation where it is necessary to support or temp…
207T00000X	Neurological Surgery Physician	A neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
207VF0040X	Urogynecology and Reconstructive Pelvic Surgery (Obstetrics & Gynecology) Physician	A subspecialist in Urogynecology and Reconstructive Pelvic Surgery is a physician in Urology or Obstetrics and Gynecology who, by virtue of education …

Related ICD-10-CM Codes

25 rows

ICD-10-CM Code	Description
C16.9	Malignant neoplasm of stomach, unspecified
C18.9	Malignant neoplasm of colon, unspecified
C20	Malignant neoplasm of rectum
C22.0	Liver cell carcinoma
C22.9	Malignant neoplasm of liver, not specified as primary or secondary
C25.9	Malignant neoplasm of pancreas, unspecified
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C34.91	Malignant neoplasm of unspecified part of right bronchus or lung
C45.9	Mesothelioma, unspecified
C50.912	Malignant neoplasm of unspecified site of left female breast

Showing 1–10 of 25

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, infusion technique, up to 1 hour, single or initial substance/drug	Commonly performed immediately after `J1448` when trilaciclib is given prior to chemotherapy; documents the administration of the cytotoxic agent
`96415`	Chemotherapy administration, each additional hour (list separately in addition to code for primary infusion)	Used when chemotherapy infusion extends beyond the initial hour following trilaciclib premedication
`96417`	Chemotherapy administration, each additional sequential infusion of a new drug, up to 1 hour	Applicable when multiple sequential IV chemotherapeutic agents are administered after trilaciclib
`96360`	Intravenous infusion, hydration; initial, 31 minutes to 1 hour	May be billed when IV hydration is provided alongside trilaciclib and chemotherapy
`96374`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intravenous push, single or initial substance	For facilities that bill an injection code for drug administration technique when applicable

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
33	Modifier 33 was created by the American Medical Association in response to the Affordable Care Act to identify services provided for preventive intent. It is appended to CPT/HCPCS codes that could be…	- Use modifier -33 when a CPT/HCPCS service that can be billed as either preventive or diagnostic/treatment is provided with preventive intent and aligns with USPSTF A or B recommendations or other…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
363LA2200X	Adult Health Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
207RC0000X	Cardiovascular Disease Physician	An internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
242T00000X	Perfusionist	A perfusionist operates extracorporeal circulation and autotransfusion equipment during any medical situation where it is necessary to support or temp…
207T00000X	Neurological Surgery Physician	A neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
207VF0040X	Urogynecology and Reconstructive Pelvic Surgery (Obstetrics & Gynecology) Physician	A subspecialist in Urogynecology and Reconstructive Pelvic Surgery is a physician in Urology or Obstetrics and Gynecology who, by virtue of education …

Related ICD-10-CM Codes

25 rows

ICD-10-CM Code	Description
C16.9	Malignant neoplasm of stomach, unspecified
C18.9	Malignant neoplasm of colon, unspecified
C20	Malignant neoplasm of rectum
C22.0	Liver cell carcinoma
C22.9	Malignant neoplasm of liver, not specified as primary or secondary
C25.9	Malignant neoplasm of pancreas, unspecified
C34.90	Malignant neoplasm of unspecified part of unspecified bronchus or lung
C34.91	Malignant neoplasm of unspecified part of right bronchus or lung
C45.9	Mesothelioma, unspecified
C50.912	Malignant neoplasm of unspecified site of left female breast

Showing 1–10 of 25

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS J1448: Injection, trilaciclib, 1mg

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HCPCS J1448: Injection, trilaciclib, 1mg

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J1448 represent and where is it typically used?

What documentation elements are specified for billing J1448?

Which modifiers might apply when billing J1448 and why?

Which CPT or administration codes are commonly reported alongside J1448?

What clinical indications and provider specialties are associated with trilaciclib (J1448) use?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J1448 represent and where is it typically used?

What documentation elements are specified for billing J1448?

Which modifiers might apply when billing J1448 and why?

Which CPT or administration codes are commonly reported alongside J1448?

What clinical indications and provider specialties are associated with trilaciclib (J1448) use?

References