HCPCS Level II J1458: Injection, galsulfase, 1 mg

HCPCS Level II code J1458 represents the billed drug product galsulfase, 1 mg, for injection, typically used as an enzyme replacement therapy administered by intravenous infusion; service type is drug administration and the typical site of service is an outpatient infusion center or hospital outpatient department.

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HCPCS Level II J1458: Injection, galsulfase, 1 mg

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Sign up for hcpcs J1458 policy alerts

Get alerted when payer policies referencing J1458 are released or updated.

Monitor payer policy activity

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Clinical & Coding Specifications

Clinical Context

A typical patient is a pediatric or adult with mucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome) who requires regular enzyme replacement therapy with galsulfase. The patient arrives to an outpatient infusion center or hospital infusion clinic for scheduled intravenous administration. Verification steps include confirming the prescription for J1458 (galsulfase, 1 mg), recent weight-based dose calculation, current labs (renal and hepatic function), and documentation of prior infusion tolerance. Nursing prepares the dose under aseptic technique, inspects the product for particulate matter, and administers via peripheral or central IV access over the manufacturer-recommended infusion time with vital sign monitoring and emergency medications available. Typical workflow elements: insurance eligibility and prior authorization confirmation, medication reconciliation, dose verification by pharmacist, informed consent for infusion risks, administration with continuous monitoring for infusion-related reactions, documentation of lot number and units billed as J1458 per milligram, and post-infusion observation prior to discharge to home or routine follow-up visits.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Used to report the professional component of the initial infusion administration if payer requires a CPT for infusion time for drug infusion services in the outpatient setting.
`96366`	Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)	Used when the infusion extends beyond the first hour and payers require time-based add-on coding.
`96367`	Intravenous infusion, additional sequential infusion of a new drug, up to 1 hour	Used if a second distinct infusion drug is administered during the same encounter.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Occasionally used for alternative routes if protocol calls for non-IV injection, though `J1458` is typically IV.
`36415`	Collection of venous blood by venipuncture	Used for pre-infusion labs such as baseline chemistries or antibody testing related to therapy.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
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Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
174400000X	Specialist	An individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
2084N0400X	Neurology Physician	A Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…
163WH0200X	Home Health Registered Nurse	Nursing Service Providers · Registered Nurse
207XX0005X	Sports Medicine (Orthopaedic Surgery) Physician	An orthopaedic surgeon trained in sports medicine provides appropriate care for all structures of the musculoskeletal system directly affected by part…
225CA2400X	Assistive Technology Practitioner Rehabilitation Counselor	Respiratory, Developmental, Rehabilitative and Restorative Service Providers · Rehabilitation Counselor

Related ICD-10-CM Codes

22 rows

ICD-10-CM Code	Description
E34.8	Other specified endocrine disorders
E34.9	Endocrine disorder, unspecified
E75.3	Sphingolipidosis, unspecified
E75.4	Neuronal ceroid lipofuscinosis
E75.5	Other lipid storage disorders
E76.1	Mucopolysaccharidosis, type II
E76.3	Mucopolysaccharidosis, unspecified
E76.9	Glucosaminoglycan metabolism disorder, unspecified
E84.0	Cystic fibrosis with pulmonary manifestations
E88.09	Other disorders of plasma-protein metabolism, not elsewhere classified

Showing 1–10 of 22

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Used to report the professional component of the initial infusion administration if payer requires a CPT for infusion time for drug infusion services in the outpatient setting.
`96366`	Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)	Used when the infusion extends beyond the first hour and payers require time-based add-on coding.
`96367`	Intravenous infusion, additional sequential infusion of a new drug, up to 1 hour	Used if a second distinct infusion drug is administered during the same encounter.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Occasionally used for alternative routes if protocol calls for non-IV injection, though `J1458` is typically IV.
`36415`	Collection of venous blood by venipuncture	Used for pre-infusion labs such as baseline chemistries or antibody testing related to therapy.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
[object Object]

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
174400000X	Specialist	An individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
2084N0400X	Neurology Physician	A Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…
163WH0200X	Home Health Registered Nurse	Nursing Service Providers · Registered Nurse
207XX0005X	Sports Medicine (Orthopaedic Surgery) Physician	An orthopaedic surgeon trained in sports medicine provides appropriate care for all structures of the musculoskeletal system directly affected by part…
225CA2400X	Assistive Technology Practitioner Rehabilitation Counselor	Respiratory, Developmental, Rehabilitative and Restorative Service Providers · Rehabilitation Counselor

Related ICD-10-CM Codes

22 rows

ICD-10-CM Code	Description
E34.8	Other specified endocrine disorders
E34.9	Endocrine disorder, unspecified
E75.3	Sphingolipidosis, unspecified
E75.4	Neuronal ceroid lipofuscinosis
E75.5	Other lipid storage disorders
E76.1	Mucopolysaccharidosis, type II
E76.3	Mucopolysaccharidosis, unspecified
E76.9	Glucosaminoglycan metabolism disorder, unspecified
E84.0	Cystic fibrosis with pulmonary manifestations
E88.09	Other disorders of plasma-protein metabolism, not elsewhere classified

Showing 1–10 of 22

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J1458: Injection, galsulfase, 1 mg

Sign up for hcpcs J1458 policy alerts

HCPCS Level II J1458: Injection, galsulfase, 1 mg

Sign up for hcpcs J1458 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J1458 represent?

What clinical and documentation steps are typically required before administering and billing J1458?

Which related CPT codes might be reported alongside J1458 for the infusion service?

What ICD-10 diagnosis codes are commonly associated with billing J1458?

Which payers cover J1458 and does the page provide reimbursement amounts?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J1458 represent?

What clinical and documentation steps are typically required before administering and billing J1458?

Which related CPT codes might be reported alongside J1458 for the infusion service?

What ICD-10 diagnosis codes are commonly associated with billing J1458?

Which payers cover J1458 and does the page provide reimbursement amounts?

References