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Gastrointestinal Manometry
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Defines Aetna's coverage and medical necessity criteria for gastrointestinal manometry procedures (antroduodenal, anorectal, colonic, and high-resolution esophageal manometry) and lists procedures considered experimental/investigational; applies to Aetna members.
No material clinical or coverage changes in this revision.
Medical Necessity and Coverage Criteria
Antroduodenal manometry — medically necessary indications
Covered when specific indications are met
Requires prior testing of gastric emptying/electrogastrography and documentation of failed conservative therapy.
Anorectal manometry — medically necessary indications
Covered when evaluating anorectal function
Include rectal balloon testing and documentation of symptoms and prior evaluation (eg, digital rectal exam, failed conservative measures).
Colonic manometry — medically necessary indications (pediatrics)
Covered to guide surgical decision-making in pediatric refractory cases
Manometry should include prolonged recording (minimum 6 hours) and provocation testing as appropriate; testing is typically available at specialized centers to distinguish pathophysiologic subtypes and inform surgical planning.
Esophageal manometry — medically necessary indications
Covered for esophageal motility evaluation
Perform after endoscopy has ruled out structural or inflammatory lesions; use CPT codes for esophageal motility studies when criteria are met.
Covered with criteria (select cases)
Coverage considerations reflect limited evidence and specialized use:
Available in select centers; evidence is limited and mainly observational (see supporting literature).
Selection and specialized center availability are emphasized in guideline and review statements.
Not routinely medically necessary
Not routinely covered / insufficient evidence
Routine use for chronic constipation or as a first-line diagnostic test lacks evidence of added value and is considered not medically necessary outside of select refractory or pre-surgical contexts.
Indications for esophageal high-resolution (impedance) manometry
Coverage aligned with guideline-recommended indications
Guidelines recommend HRM prior to antireflux surgery and as the preferred modality for characterizing motility disorders.
HRIM with postprandial monitoring is recommended in specific scenarios by guideline statements.
Indications for anorectal and colonic manometry in pediatric Hirschsprung disease
Pediatric postoperative Hirschsprung disease evaluation
ARM protocols and outcomes in this population are heterogeneous; use standardized protocols where possible.
Evidence is limited and heterogeneous; testing is typically low-resolution in published pediatric series and should be interpreted by experienced teams.
Antroduodenal manometry, anorectal manometry, colonic motility studies, and high-resolution esophageal manometry are addressed by this policy. In particular, antroduodenal manometry is considered medically necessary for members with dyspepsia, gastroparesis, or chronic intestinal pseudo-obstruction who have unexplained upper gastrointestinal symptoms (for example, nausea or vomiting) when gastric emptying is normal or equivocal and severe symptoms persist despite empiric conservative management. Anorectal manometry (including rectal sensation, tone, and compliance testing) is medically necessary for evaluation of anorectal function (eg, chronic constipation, fecal incontinence). Colonic manometry is considered medically necessary to guide surgical decision-making in children with refractory colonic motility/defecatory disorders. High-resolution esophageal manometry is considered medically necessary for diagnosis of esophageal motility disorders in persons with dysphagia (including achalasia, rumination syndrome, or PPI-refractory chest pain) and for preoperative evaluation prior to anti-reflux surgery.
Colonic manometry is not appropriate for most patients and is generally limited to research settings or specialized centers; available clinical use is primarily in selected centers where results may inform management of refractory cases. UpToDate and guideline summaries note that, although colonic manometry provides detailed information about motor patterns and can categorize normal, myopathic, or neuropathic patterns, there is currently insufficient evidence that this information has added value for routine management of chronic constipation in general clinical practice.
Evidence for the routine use of high-resolution colonic manometry in the post-operative evaluation of children with Hirschsprung disease is limited and heterogeneous. Guidelines (American Pediatric Surgical Association) recommend colonic manometry when colonic motility studies are abnormal to better determine the location and nature of dysmotility, but systematic reviews highlight sparse, low-quality, and methodologically variable studies that limit broad conclusions about diagnostic performance and clinical impact.
Antroduodenal manometry can characterize fasting and postprandial motor patterns of the distal stomach and proximal small bowel, but its incremental clinical value is limited when standard tests of gastric function are abnormal. If gastric emptying studies or electrogastrography already demonstrate delayed emptying or abnormal myoelectrical activity, antroduodenal manometry generally does not provide additional actionable information and should be reserved for the specific indications listed in this policy.
Routine use of colonic manometry for evaluation of chronic constipation or as a first-line diagnostic test lacks evidence of added value. Reviews and guideline statements emphasize that the test is resource-intensive, available in only selected centers, and has not been shown in well-designed studies to improve management or outcomes for most patients; therefore its routine application is not supported.
Diagnosis of Ineffective Esophageal Motility (IEM) by high-resolution manometry relies on manometric thresholds (for example, distal contractile integral <450 mmHg·s·cm in ≥50% of ten liquid swallows), but manometric classification alone does not consistently correlate with symptom severity or impaired esophageal function. Studies and reviews note that many patients with IEM may have normal bolus transit or minimal symptoms, so manometric findings should be interpreted in the context of clinical presentation and additional diagnostic data before directing therapy.
Procedure and Diagnosis Codes
| 91010 | Esophageal motility (manometric study of the esophagus and/or gastroesophageal junction) study with interpretation and report. |
| +91013 | with stimulation or perfusion (eg, stimulant, acid or alkali perfusion). |
| 91117 | Colon motility (manometric) study, minimum 6 hours continuous recording (including provocations tests, eg, meal, intracolonic balloon distension, pharmacologic agents, if performed), with interpretation and report. |
| 91120 | Rectal sensation, tone, and compliance test (ie, response to graded balloon distention). |
| 91122 | Anorectal manometry. |
| 91020 | Gastric motility (manometric studies). |
| 43235 | Esophagogastroduodenoscopy, flexible, transoral; diagnostic (when performed). |
| K21.00-K21.9 | Gastro-esophageal reflux disease. |
| K22.4 | Dyskinesia of esophagus. |
| K30 | Functional dyspepsia. |
| K31.84 | Gastroparesis. |
| K56.0-K56.7 | Paralytic ileus and intestinal obstruction without hernia [includes chronic intestinal pseudo-obstruction]. |
| K59.00-K59.09 | Constipation. |
| K59.8 | Other specified functional intestinal disorders. |
| R11.0-R11.2 | Nausea and vomiting. |
| R15.0 | Incomplete defecation. |
| MRI capsule marker | Magnetic resonance imaging (MRI) capsule marker methods- no specific code. |
| No codes listed |
Provider Requirements, Prior Authorization, and Documentation
Prior Authorization / Coverage‑Linked Codes
Prior authorization is required for gastrointestinal manometry procedures when coverage is linked to medical necessity criteria. Include relevant CPT/ICD-10 codes and documentation with the prior authorization request.
- Prior authorization required when selection criteria must be met.
- Attach applicable procedure and diagnosis codes with request.
Prior Authorization for Specialized Motility Testing
Specialized motility testing (eg, antroduodenal manometry, prolonged or pediatric colonic manometry, high‑resolution esophageal manometry) requires prior authorization when used to establish diagnosis or to guide management or surgery. Requests should state the specific motility test, indication, and prior test results.
- Specify test type (eg, antroduodenal, colonic, anorectal, high‑resolution esophageal).
- Provide clinical indication and prior work‑up results (see Required Clinical Documentation callout).
Prior Authorization Requirement (Follow Clinical Policy Bulletin Procedures)
Prior authorization must follow the Clinical Policy Bulletin procedures; absence of authorization or supporting documentation may result in denial. Providers should use payer prior authorization portals or contact the plan per standard procedures.
- Follow Aetna/CPB prior authorization process.
- Lack of required documentation or authorization increases denial risk.
Experimental / Investigational Triggers Denial
The policy designates certain procedures as experimental/investigational for indications not listed as medically necessary. Requests for these indications will be denied.
- Antroduodenal manometry not covered for indications outside listed medically necessary uses.
- Colonic motility studies not covered for indications outside listed medically necessary uses.
- MRI capsule marker methods for whole gut transit are investigational.
Guideline‑Based Limitation Risk
Some services are limited by guideline recommendations and consensus statements (eg, use of colonic manometry primarily in specialized centers, HRM preferred over conventional manometry). Requests inconsistent with guideline‑based limitations may be denied or require additional justification.
- Colonic manometry generally limited to selected/refractory patients or research/specialty centers.
- High‑resolution esophageal manometry preferred over conventional for many indications.
- Guideline-based limits may require additional documentation of necessity.
Policy History and Review Dates Noted
Policy history and review dates: Effective date, last review, and next scheduled review are documented in the policy. Include these if relevant to administrative review.
- Effective: 05/14/2002
- Last Review: 09/11/2023
- Next Review: 07/11/2024
Codes to Include with Documentation
Include the following codes with documentation when submitting prior authorization or claims: covered CPT codes when selection criteria are met and relevant ICD‑10 diagnoses. If an investigational or not‑covered code/indication is submitted, provide rationale and supporting evidence.
- Attach CPT code(s) for the specific manometry procedure.
- Attach ICD‑10 diagnosis codes supporting the medical necessity.
- If applicable, include related procedure codes (eg, 43235 EGD) used in the diagnostic pathway.
Documentation to Support Surgical Decision‑Making
Documentation should support use of manometry to guide surgical decision‑making when applicable (eg, colonic manometry results used to decide colectomy or cecostomy). Provide description of how results influenced planned surgery and prior non‑surgical management.
- Describe how manometry findings affect the surgical plan (eg, presence/absence of HAPCs, response to provocation).
- Include prior conservative treatments tried and outcomes.
- Provide surgical indication and anticipated benefit tied to manometry results.
Required Clinical Documentation (e.g., Endoscopy First, HRM Preferred)
Required clinical documentation includes: prior diagnostic testing (eg, endoscopy/EGD results, gastric emptying studies, electrogastrography), description of symptoms (eg, dysphagia, refractory constipation, nausea/vomiting), trial of conservative therapies, and rationale for the selected motility test. For esophageal symptoms, endoscopy should generally precede manometry; high‑resolution manometry is preferred.
- Recent endoscopy results when evaluating dysphagia or pre‑antireflux surgery.
- Gastric emptying and/or electrogastrography results when considering antroduodenal manometry.
- Clinical history and severity, including duration of symptoms.
- Documentation of trials of conservative/medical therapies and responses (see Trial of Conservative Therapies callout).
- Specific test protocol (eg, duration of colonic manometry, provocation maneuvers).
Trial of Conservative Therapies Before Invasive Testing
A trial of conservative therapies is required before invasive motility testing such as antroduodenal manometry in many indications. Document specific empiric therapeutic trials and their duration and response.
- Document trials of antiemetic and/or prokinetic agents for nausea/vomiting.
- Document conservative management for constipation or defecatory disorders, including biofeedback and pharmacologic therapies.
- Record duration and lack of adequate response to conservative measures.
Placeholder Provider Action (Not Specified)
No additional provider action specified in this document beyond the requirements above; follow payer instructions for submission and contact the plan for questions.
- If uncertain, contact Aetna for clarification or prior authorization support.
Clinical Background and Scope
Antroduodenal manometry measures contractile activity of the distal stomach and proximal small bowel using a catheter with perfusion ports or solid-state transducers. Recordings typically span from 5 to 24 hours and include assessment of fasting and postprandial motor patterns; interpretation requires specialized expertise and is intended to evaluate complex or unexplained upper gastrointestinal motor disorders when prior, less-invasive testing and conservative therapies have not provided an explanation or resolution.
Definitions and Key Terms
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