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    v1.0.30
    OpenPayerBilling CodesEsophagogastroduodenoscopy ProceduresCPT cpt-43235-diagnostic-esophagogastroduodenoscopy-egd
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    CPT 43235: Esophagogastroduodenoscopy, Diagnostic

    Medicare pays $335 and commercial payers pay $655 on average nationally for this procedure.

    CPT code 43235 describes an esophagogastroduodenoscopy (EGD) diagnostic procedure in which a provider passes an endoscope through the mouth into the esophagus, stomach, and duodenum for visualization and possible specimen collection by brushing or washing; service type: diagnostic endoscopy, typical site of service: outpatient endoscopy suite or hospital-based endoscopy unit.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    National Reimbursement Benchmarks

    Nationally, Medicare’s mean allowed amount for CPT 43235 sits at $335.20 while BUCA’s mean commercial rate is substantially higher at $655.40, reflecting a commercial-to-Medicare gap of $320.20. That delta highlights the common pattern of commercial averages outpacing Medicare for this service, with BUCA about 95% above Medicare on mean rates.

    Dispersion varies meaningfully by payer. Blue Cross Blue Shield exhibits one of the widest interquartile spreads (P75–P25 = $889.30), followed by BUCA (P75–P25 = $622.70) and UnitedHealth Group (P75–P25 = $268.60). Aetna and Cigna show tighter IQRs at $214.00 and $257.30 respectively, indicating more compressed rate distributions for those payers.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient presents to a gastroenterology clinic with a 3-month history of intermittent epigastric pain (R10.13), reflux symptoms consistent with gastro-esophageal reflux disease (K21.9), intermittent nausea (R11.0), and new onset melena or worsening dyspepsia raising concern for peptic ulcer disease (K25.9, K29.70). After outpatient evaluation including history, physical exam, and failure of initial medical therapy, the gastroenterologist schedules an esophagogastroduodenoscopy for diagnostic evaluation. The procedure involves insertion of an upper endoscope through the mouth to visualize the esophagus, stomach, and duodenum, assess mucosal abnormalities, obtain washings or brushings if needed, and consider targeted biopsies. Typical workflow includes pre-procedure consent and sedation assessment, procedure performed in an endoscopy suite or hospital outpatient endoscopy unit, recovery in a monitored recovery area, pathology processing if specimens obtained, and follow-up visit to discuss findings and pathology results.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43239

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RG0100X
    207Q00000X
    207R00000X
    207LP4000X
    207PS0010X
    207RH0000X
    152W00000X
    103T00000X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    E86.0Dehydration
    K21.9Gastro-esophageal reflux disease without esophagitis
    K22.2Esophageal obstruction
    K25.9Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K26.9Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K27.9Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
    K28.9Gastrojejunal ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K29.70Gastritis, unspecified, without bleeding
    K29.71Gastritis, unspecified, with bleeding
    K31.84Gastroparesis

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-43210-ESOPHAGOGASTRODUODENOSCOPY-WITH-FUNDOPLICATION

    CPT 43210: Esophagogastroduodenoscopy with Fundoplication

    CPT-43236-UPPER-ENDOSCOPY-SUBMUCOSAL-INJECTION

    CPT 43236: Esophagogastroduodenoscopy with Submucosal Injection

    CPT-43237-UPPER-ENDOSCOPY-WITH-ENDOSCOPIC-ULTRASOUND-EUS

    CPT 43237: Esophagogastroduodenoscopy with Endoscopic Ultrasound

    CPT-43238-ENDOSCOPIC-ULTRASOUND-FNA-BIOPSY-UPPER-GI

    CPT 43238: Endoscopic Ultrasound with FNA/Biopsy

    CPT-43239-ESOPHAGOGASTRODUODENOSCOPY-WITH-BIOPSY

    CPT 43239: Esophagogastroduodenoscopy with Biopsy

    CPT-43240-ENDOSCOPIC-PSEUDOCYST-DRAINAGE-STENT-PLACEMENT

    CPT 43240: Endoscopic Drainage of Gastrointestinal Pseudocyst

    CPT-43241-UPPER-ENDOSCOPY-WITH-TUBE-OR-CATHETER-PLACEMENT

    CPT 43241: EGD with Enteral Tube or Catheter Placement

    CPT-43242-EUS-GUIDED-FNA-BIOPSY-UPPER-GI

    CPT 43242: EUS-Guided Upper GI Fine Needle Aspiration/Biopsy

    CPT-43243-ENDOSCOPIC-SCLEROTHERAPY-ESOPHAGUS-STOMACH

    CPT 43243: Endoscopic Sclerotherapy of Esophagus/Stomach/Duodenum

    CPT-43244-ENDOSCOPIC-VARICEAL-BAND-LIGATION

    CPT 43244: Endoscopic Variceal Band Ligation

    Showing 1–10 of 25

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

    Esophagogastroduodenoscopy, with biopsy, single or multiple
    Offers targeted mucosal biopsy when tissue sampling is required in addition to diagnostic visualization performed with 43235.

    | 43248 | Esophagogastroduodenoscopy, with insertion of guide wire followed by dilation | Performed when a stricture requiring guide wire-assisted dilation is identified during diagnostic EGD.

    | 43249 | Esophagogastroduodenoscopy, with balloon dilation | Performed when endoscopic balloon dilation of a narrowing is needed after diagnostic endoscopy.

    | 43251 | Esophagogastroduodenoscopy, with removal of tumor(s), polyp(s), or other lesion(s) | Performed when lesion removal or polypectomy is done during the endoscopic session following diagnostic evaluation.

    | 43259 | Esophagogastroduodenoscopy, with endoscopic ultrasound examination | Performed when endoscopic ultrasound is required for further staging or evaluation of submucosal lesions identified during diagnostic EGD.