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    OpenPayerBilling CodesAbnormal findings on examination of blood, without diagnosisICD-10-CM r77-other-abnormalities-of-plasma-proteins
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    ICD-10-CM Code For Other Abnormalities Of Plasma Proteins: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group R77 includes abnormal laboratory findings of plasma proteins such as paraproteinemia, monoclonal gammopathy, and other atypical serum protein results without a definitive underlying diagnosis. These ICD-10-CM diagnosis codes are used to document clinical scenarios where abnormal protein electrophoresis or serum protein testing is identified, capturing disease severity, organ involvement, or clinical complexity relevant to hematologic or immunologic evaluation. Accurate coding within the ICD-10-CM R77 group supports proper claim adjudication / complete clinical documentation / appropriate reimbursement.

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    ICD-10-CM R77: Other Abnormalities Of Plasma Proteins Overview

    The diagnoses in this group represent abnormal laboratory findings related to plasma proteins, such as paraproteins or other abnormal serum protein fractions detected on blood testing. These findings target hematologic and immunologic assessments rather than a definitive disease diagnosis. Accurate coding matters for reimbursement because it documents the clinical reason for testing and supports medical necessity for services related to evaluation and monitoring.

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    When to Use

    Use a code from this group when laboratory testing reveals abnormal plasma protein results and no definitive diagnosis has been established to explain the finding. These codes are appropriate for reporting the clinical finding that prompted further evaluation, monitoring, or referral.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    R77.0Abnormality of albumin
    R77.1Abnormality of globulin
    R77.2Abnormality of alphafetoprotein
    R77.8Other specified abnormalities of plasma proteins
    R77.9Abnormality of plasma protein, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    947Signs and Symptoms with MCC
    948Signs and Symptoms without MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with new-onset generalized edema and fatigue; initial laboratory testing shows markedly low serum albumin with preserved liver enzymes and no obvious nephrotic-range proteinuria on urinalysis, prompting evaluation for hypoalbuminemia of unclear cause. A diagnosis from this group is assigned to document the abnormal plasma protein finding pending further workup. Typical codes: R77.1, R77.9
    • A middle-aged patient in an outpatient hematology clinic undergoing evaluation for monoclonal gammopathy has serum protein electrophoresis and immunofixation demonstrating an abnormal M‑protein spike without signs or symptoms of multiple myeloma or related organ damage. The abnormal plasma protein laboratory result is coded to record the finding while the patient is observed for progression. Typical codes: R77.0, R77.9
    • A hospitalized patient with sepsis develops sudden changes in serum immunoglobulin levels and abnormal total protein measurements noted on daily chemistry panels; these abnormalities are documented as contributing lab findings and as a comorbidity affecting ongoing management. A code from this group is used to capture the abnormal plasma protein values observed during the acute illness. Typical codes: R77.2, R77.8

    Related Codes

    R70-ELEVATED-ERYTHROCYTE-SEDIMENTATION-RATE

    ICD-10-CM Code For Elevated Erythrocyte Sedimentation Rate And Abnormality Of Plasma Viscosity: Group Overview

    R71-ABNORMALITY-OF-RED-BLOOD-CELLS

    ICD-10-CM Code For Abnormality Of Red Blood Cells: Group Overview

    R73-ELEVATED-BLOOD-GLUCOSE-LEVEL

    ICD-10-CM Code For Elevated Blood Glucose Level: Group Overview

    R74-ABNORMAL-SERUM-ENZYME-LEVELS

    ICD-10-CM Code For Abnormal Serum Enzyme Levels: Group Overview

    R75-INCONCLUSIVE-HIV-LABORATORY-EVIDENCE

    ICD-10-CM Code For Inconclusive Laboratory Evidence Of Human Immunodeficiency Virus: Group Overview

    R76-OTHER-ABNORMAL-IMMUNOLOGICAL-FINDINGS

    ICD-10-CM Code For Other Abnormal Immunological Findings In Serum: Group Overview

    R78-FINDINGS-OF-DRUGS-AND-OTHER-SUBSTANCES

    ICD-10-CM Code For Findings Of Drugs And Other Substances Not Normally Found In Blood: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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