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    v1.0.28
    OpenPayerBilling CodesAbnormal findings on examination of blood, without diagnosisICD-10-CM r74-abnormal-serum-enzyme-levels
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    ICD-10-CM Code For Abnormal Serum Enzyme Levels: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group R74 includes abnormal serum enzyme levels such as elevated transaminases, alkaline phosphatase, and other enzyme abnormalities that indicate possible liver, biliary, or muscle pathology. These ICD-10-CM diagnosis codes are used to document laboratory-detected enzyme abnormalities when a definitive underlying diagnosis has not been established, capturing severity and organ involvement when specified. Accurate coding within the ICD-10-CM R74 group supports complete clinical documentation and appropriate claim adjudication.

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    ICD-10-CM R74: Abnormal Serum Enzyme Levels Overview

    This group represents abnormal findings of serum enzyme concentrations detected on laboratory testing, typically involving hepatic or muscle enzymes. It targets biochemical abnormalities rather than a specific disease diagnosis and may signal liver injury, muscle damage, or other metabolic disturbances. Accurate coding matters because it distinguishes laboratory abnormalities from definitive disease diagnoses and supports appropriate clinical documentation and claim processing.

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    When to Use

    Assign a code from this group when laboratory tests show abnormal serum enzyme levels and no definitive cause has been documented in the medical record. Use these codes to report the abnormal test result while further evaluation or diagnosis is pending.

    ICD-10-CM Codes

    4 rows

    ICD-10-CM CodeDescription
    R74.01Elevation of levels of liver transaminase levels
    R74.02Elevation of levels of lactic acid dehydrogenase [LDH]
    R74.8Abnormal levels of other serum enzymes
    R74.9Abnormal serum enzyme level, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    947Signs and Symptoms with MCC
    948Signs and Symptoms without MCC

    Typical Clinical Scenarios

    • An adult patient presents to urgent care with new-onset jaundice, dark urine, and right upper quadrant discomfort after starting a statin two weeks ago. Liver function tests show a marked isolated elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with otherwise unremarkable imaging and no established hepatic diagnosis; a code from this group is used to capture the abnormal serum enzyme findings pending further workup and medication review. Typical codes: R74.02
    • A middle-aged patient with long-standing type 2 diabetes is seen at a routine primary care visit for monitoring; laboratory studies reveal chronically mild-to-moderate elevations of alkaline phosphatase without symptoms, and prior hepatobiliary imaging has been nondiagnostic. The abnormal enzyme result is recorded as a finding to document abnormal blood chemistry in the context of chronic disease management and to prompt surveillance. Typical codes: R74.8
    • An older adult is admitted from the emergency department after a fall and is found on admission labs to have isolated elevated gamma-glutamyl transferase (GGT) and alkaline phosphatase during evaluation for bone pain and suspected metastatic disease. Because no definitive diagnosis explaining the enzyme elevations is yet established at admission, an abnormal serum enzyme level code is assigned as a comorbidity to document the lab abnormality affecting inpatient evaluation. Typical codes: R74.01, R74.9

    Related Codes

    R70-ELEVATED-ERYTHROCYTE-SEDIMENTATION-RATE

    ICD-10-CM Code For Elevated Erythrocyte Sedimentation Rate And Abnormality Of Plasma Viscosity: Group Overview

    R71-ABNORMALITY-OF-RED-BLOOD-CELLS

    ICD-10-CM Code For Abnormality Of Red Blood Cells: Group Overview

    R73-ELEVATED-BLOOD-GLUCOSE-LEVEL

    ICD-10-CM Code For Elevated Blood Glucose Level: Group Overview

    R75-INCONCLUSIVE-HIV-LABORATORY-EVIDENCE

    ICD-10-CM Code For Inconclusive Laboratory Evidence Of Human Immunodeficiency Virus: Group Overview

    R76-OTHER-ABNORMAL-IMMUNOLOGICAL-FINDINGS

    ICD-10-CM Code For Other Abnormal Immunological Findings In Serum: Group Overview

    R77-OTHER-ABNORMALITIES-OF-PLASMA-PROTEINS

    ICD-10-CM Code For Other Abnormalities Of Plasma Proteins: Group Overview

    R78-FINDINGS-OF-DRUGS-AND-OTHER-SUBSTANCES

    ICD-10-CM Code For Findings Of Drugs And Other Substances Not Normally Found In Blood: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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