Summary & Overview
HCPCS Level II S0106: Bupropion HCl Sustained‑Release 150 mg, 60 Tablets
HCPCS Level II code S0106 denotes a 60‑tablet bottle of bupropion HCl sustained‑release 150 mg. This code identifies a common outpatient prescription product used in the management of depressive disorders and for smoking cessation support in clinical practice. Nationally, accurate identification of drug product codes like S0106 matters for pharmacy reimbursement, claims adjudication, utilization tracking, and formulary management.
Key payers included in this overview are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise briefing on the clinical product described by the code, the typical site of service, and the administrative context for billing and coverage. The publication outlines what readers can expect regarding benchmarks and coverage patterns (where available), common billing modifiers associated with pharmacy and outpatient services, and the clinical context for the medication’s use.
The content also highlights typical pharmacy service-line considerations such as dispensing unit, packaging (60 tablets per bottle), and sustained‑release formulation implications for dosing and utilization. Data not available in the input are explicitly noted elsewhere, and the material is presented for national audiences seeking a practical reference on HCPCS Level II code S0106.
Billing Code Overview
HCPCS Level II code S0106 represents bupropion hcl sustained release tablet, 150 mg, per bottle of 60 tablets. The service type is prescription medication dispensing for a sustained-release formulation of bupropion hydrochloride. The typical site of service is outpatient pharmacy dispensing or other community pharmacy settings where prescription medications are dispensed to patients.
Clinical & Coding Specifications
Clinical Context
A 34-year-old outpatient diagnosed with major depressive disorder presents to a primary care clinic for medication management. The clinician prescribes S0106 (bupropion HCl sustained release 150 mg, bottle of 60) as part of an antidepressant regimen. Typical workflow: provider documents diagnosis and medication indication in the electronic health record, verifies prior medication history and contraindications (seizure disorder, eating disorder, concomitant MAOI use), writes or electronically transmits the prescription to the in-house pharmacy or external pharmacy, and creates medication administration and counseling notes in the chart. Pharmacy dispenses the medication, records lot and NDC information, and bills the patient’s medical or pharmacy benefit depending on payer policy. Follow-up visits assess efficacy, side effects, and adherence; dose adjustments or additional therapies are documented in subsequent encounters.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier | Use when no specific modifier applies to the dispensed medication claim. |
22 | Increased procedural services |