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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j2430-pamidronate-disodium-injection-30mg
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    HCPCS Level II J2430: Injection, pamidronate disodium, per 30 mg

    HCPCS Level II code J2430 represents administration billing for the medication pamidronate disodium formulated for injection, described as Injection, pamidronate disodium, per 30 mg; this code is used when reporting the drug itself for infusion or IV administration in settings such as outpatient infusion centers, hospital outpatient departments, or physician office infusion suites and reflects the per‑30 mg billing unit for the injectable bisphosphonate used in conditions requiring intravenous pamidronate.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with bone metastases from breast or prostate cancer, or with multiple myeloma, who requires intravenous bisphosphonate therapy for reduction of skeletal-related events and relief of bone pain. The oncology clinic receives an order for J2430 (pamidronate disodium, per 30 mg). The workflow includes verification of the diagnosis and prior authorization if needed, review of renal function and serum calcium, preparation of the dose in the outpatient infusion suite or hospital infusion center, administration via slow IV infusion over the recommended time (per institutional protocol), monitoring for infusion reactions and hypocalcemia during and for a period after infusion, documentation of lot numbers and administered units, and billing using J2430 multiplied by the number of 30 mg units infused. Typical sites of service are outpatient hospital infusion center, physician office infusion suite, or ambulatory infusion centers serving oncology and hematology patients.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96413Chemotherapy administration, IV infusion technique; up to 1 hour, single or initial substance/drugUsed when pamidronate is administered and infusion time falls within this billing window for IV therapeutic infusion

    96415 | Chemotherapy administration, IV infusion technique; each additional hour (List separately in addition to code for primary infusion) | Billed for extended infusion durations beyond the initial hour when clinically indicated

    96365 | Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hour | Alternative for non-chemotherapy therapeutic infusions in physician office settings when payer allows

    96366 | Each additional hour (List separately in addition to code for primary infusion) | Used for additional time beyond the initial infusion period for non-chemotherapy infusions

    99070 | Supplies and materials (e.g., saline flushes, IV tubing) provided by the physician over and above those usually included with the service | Billed when additional supplies used for preparation/administration of pamidronate are not included in infusion code

    36415 | Collection of venous blood by venipuncture | Performed prior to infusion for baseline labs such as serum creatinine and calcium

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    193200000XMulti-Specialty GroupA business group of one or more individual practitioners, who practice with different areas of specialization.
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    2255R0406XBlind Rehabilitation Specialist/TechnologistRespiratory, Developmental, Rehabilitative and Restorative Service Providers · Specialist/Technologist
    2084P0005XNeurodevelopmental Disabilities PhysicianA neurologist who specializes in the treatment of individuals with developmental delays and learning disorders associated with cerebral palsy, spina b…
    385HR2060XChild Intellectual and/or Developmental Disabilities Respite CareA facility or distinct part of a facility that provides short term, residential care to children diagnosed with intellectual and/or developmental disa…

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    1 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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