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    v1.0.30
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j2182-mepolizumab-injection-1mg
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    HCPCS J2182: Injection, mepolizumab, 1 mg

    HCPCS Level II code J2182 describes a single unit of mepolizumab injection, 1 mg, an injectable monoclonal antibody preparation typically administered as an intravenous or subcutaneous biological therapy in outpatient infusion centers, physician offices, or specialty clinics for conditions requiring anti–IL‑5 therapy.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult or adolescent with severe eosinophilic asthma or eosinophilic granulomatosis with polyangiitis receiving subcutaneous biologic therapy. The patient presents to an outpatient infusion clinic, specialty pharmacy clinic, or physician office for administration of J2182 (mepolizumab, 1 mg). The clinical workflow includes verification of patient identity and insurance, review of recent clinical notes and indication, confirmation of recent blood eosinophil count and prior authorization status, preparation of the prefilled syringe or vial, administration via subcutaneous injection, observation for immediate adverse reactions (typically 15–30 minutes), and documentation of lot number, dose, route, site, and any reactions.

    Typical site of service: outpatient infusion clinic, specialty clinic, injection suite, or physician office.

    Common clinical scenario: a patient with uncontrolled severe eosinophilic asthma on inhaled controller therapy with elevated blood eosinophils who qualifies for mepolizumab by guideline criteria and payer coverage, returns every 4 weeks for subcutaneous injection. The visit includes review of control, interval adverse events, and recording of medication administration details.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96401Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic (single or initial substance/drug)Used when payers classify biologic injections under parenteral drug administration codes; documents the professional administration service when required.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommonly used to report the administration service for a subcutaneous biologic injection like mepolizumab when separate administration code is billable.
    99070Supplies and materials (e.g., bandages, syringes) provided by the physician over and above those usually included with the procedureUsed to report ancillary supplies not included in the drug J-code billing when payer allows.
    36415Collection of venous blood by venipunctureUsed when a blood eosinophil count or other labs are drawn at the visit to assess therapy response or safety.
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityOften billed when the clinician provides evaluation and management services on the same day as the injection and documentation meets E/M criteria.

    Note: If facility billing applies, drug J-code J2182 is billed for the mepolizumab product and the related administration CPT codes are billed per payer rules.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RP1001X
    207RI0011X
    363A00000X
    163W00000X
    207L00000X
    261QP2300X
    2083T0002X
    103TC1900X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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