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HCPCS J1576: Immune Globulin (Panzyga) IV, 500 mg

HCPCS Level II code J1576 represents administration of immune globulin (Panzyga), intravenous, non-lyophilized (liquid), per 500 mg. This code is used to bill for doses of a plasma-derived immunoglobulin product delivered intravenously for immune replacement or modulation. Nationally, accurate coding for intravenous immunoglobulin (IVIG) products is important for standardized reimbursement, clinical documentation, and supply-chain management given the high cost and frequent use in immunodeficiency, autoimmune, and neurologic conditions.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of clinical context for IVIG administration, descriptions of typical sites of service (hospital outpatient infusion centers, physician office infusion suites, ambulatory infusion centers), and what to expect in billing practice when using J1576 for Panzyga dosing. The publication outlines common billing considerations, benchmarking topics, and recent policy themes relevant to high-cost biologic infusions. Data not available in the input for specific reimbursement rates, associated taxonomies, ICD-10 diagnoses, and related codes are noted as unavailable in the input.

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Billing Code Overview

HCPCS Level II code J1576 describes an intravenous injection of immune globulin (Panzyga), non-lyophilized (liquid), measured per 500 mg. The service represents administration of a plasma-derived immune globulin formulation used for immune modulation or replacement therapies.

Service type: Intravenous infusion/therapeutic infusion

Typical site of service: Hospital outpatient infusion center, physician office infusion suite, or ambulatory infusion center

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HCPCS J1576: Immune Globulin (Panzyga) IV, 500 mg

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Get alerted when payer policies referencing J1576 are released or updated.

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Billing Code Overview

Service type: Intravenous infusion/therapeutic infusion

Typical site of service: Hospital outpatient infusion center, physician office infusion suite, or ambulatory infusion center

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with primary immunodeficiency or a patient with an autoimmune or neurologic condition requiring intravenous immune globulin (IVIG) therapy who presents to an outpatient infusion center or hospital outpatient department for medication administration. The product administered is J1576 (immune globulin, Panzyga, intravenous, liquid, 500 mg unit). Clinical workflow: patient arrives for scheduled infusion following prior authorization and documented diagnosis; nursing performs baseline vitals and allergy review; an IV is established (peripheral or central access) and the IVIG is prepared and checked by pharmacy for dose calculation based on patient weight and concentration; infusion is initiated at a slow rate with vital sign monitoring and escalation of rate per protocol if tolerated; any infusion reactions are managed per institutional guidelines; infusion documentation includes lot numbers, units administered, start/stop times, infusion rate changes, and concomitant medications. Typical sites of service include outpatient infusion centers, hospital outpatient departments, and inpatient wards for acute or complex cases. Common accompanying processes include pre-infusion laboratory evaluation (e.g., CBC, CMP), management of infusion-related adverse effects, and coordination of payer authorization and billing using appropriate modifiers.

Coding Specifications

Modifier	Description	When to Use
`00`	No modifier	Default; when no specific modifier applies to the service
`22`	Increased procedural services	Use when IVIG administration requires substantially greater resources (e.g., extensive nursing time for severe infusion reactions)
`23`	Unusual anesthesia	Rare for IVIG; apply if unexpected anesthesia is required for infusion-related procedures
`52`	Reduced services	Use when a planned full infusion is partially reduced (e.g., infusion stopped early for clinical reasons)
`53`	Discontinued procedure	Use when the infusion is started but terminated due to adverse reaction or clinical instability
`54`	Surgical care only	Typically not applicable; reserved for surgical contexts
`55`	Postoperative management only	Not typically applicable for IVIG administration
`56`	Preoperative management only	Not typically applicable for IVIG administration
`62`	Two surgeons	Not applicable to IVIG infusion; reserved for surgical procedures
`76`	Repeat procedure by same provider	Use when a repeated IVIG infusion is administered by the same provider on the same day
`78`	Return to OR	Not applicable to IVIG infusion
`80`	Assistant surgeon	Not applicable to IVIG infusion
`82`	Assistant surgeon (when qualified resident unavailable)	Not applicable to IVIG infusion
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery	Not applicable to IVIG infusion
`CQ`	Service furnished by a resident, not teaching physician	Use if a resident provided the infusion without attending involvement per payer rules

Taxonomy Code	Specialty	Notes
`207RH0000X`	Hematology & Oncology	Hematologists frequently manage primary immunodeficiency and coordinate IVIG therapy
`2080P0207X`	Allergy & Immunology	Allergists/immunologists commonly prescribe and oversee IVIG for immunodeficiency and autoimmune conditions
`207L00000X`	Infusion Therapy	Infusion specialists and advanced practice nurses provide IVIG administration and monitoring
`261QA1900X`	Hospitalist Medicine	Hospitalists manage inpatient IVIG infusions for acute indications
`207K00000X`	Neurology	Neurologists order IVIG for conditions such as CIDP and Guillain-Barré syndrome

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`D80.0`	Hereditary hypogammaglobulinemia	Primary immunodeficiency treated with regular IVIG replacement therapy
`D83.0`	Common variable immunodeficiency	IVIG is standard treatment to prevent infections and maintain IgG levels
`D84.9`	Immunodeficiency, unspecified	IVIG may be indicated when immunodeficiency is documented and replacement therapy is required
`G61.0`	Guillain-Barré syndrome	IVIG is a first-line immune-modulating therapy for acute GBS
`G61.81`	Chronic inflammatory demyelinating polyneuropathy (CIDP)	IVIG is an FDA-approved therapy for CIDP to improve neurologic function and slow progression
`M35.9`	Systemic involvement of connective tissue disease, unspecified	IVIG used as immunomodulatory therapy in select autoimmune connective tissue disorders
`M32.10`	Systemic lupus erythematosus, organ or system involvement unspecified	IVIG may be used in refractory or severe autoimmune manifestations as adjunctive therapy

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, infusion technique; intravenous, up to 1 hour, single or initial drug	Often used for billing IV infusion nursing time for therapies like IVIG when payer guidance permits documenting infusion administration duration
`96415`	Each additional hour (chemotherapy/infusion)	Used to report extended infusion time beyond the initial hour when applicable to IVIG infusions requiring prolonged administration
`36415`	Collection of venous blood by venipuncture	Commonly performed prior to infusion for baseline laboratory monitoring (e.g., CMP, CBC)
`36561`	Insertion of tunneled centrally inserted central venous catheter, without subcutaneous port	Performed when long-term or repeated IVIG infusions require central access
`96360`	Intravenous infusion, hydration; initial, 31 minutes to 1 hour	Sometimes used per payer rules for non-chemotherapy infusion administration of IVIG if specific infusion codes are not accepted

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS J0120: Injection, Tetracycline, Up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS J0122: Injection, Eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS J0131: Injection Acetaminophen, 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS J0134: Injection, Acetaminophen (Fresenius Kabi), 10 mg

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`00`	No modifier	Default; when no specific modifier applies to the service
`22`	Increased procedural services	Use when IVIG administration requires substantially greater resources (e.g., extensive nursing time for severe infusion reactions)
`23`	Unusual anesthesia	Rare for IVIG; apply if unexpected anesthesia is required for infusion-related procedures
`52`	Reduced services	Use when a planned full infusion is partially reduced (e.g., infusion stopped early for clinical reasons)
`53`	Discontinued procedure	Use when the infusion is started but terminated due to adverse reaction or clinical instability
`54`	Surgical care only	Typically not applicable; reserved for surgical contexts
`55`	Postoperative management only	Not typically applicable for IVIG administration
`56`	Preoperative management only	Not typically applicable for IVIG administration
`62`	Two surgeons	Not applicable to IVIG infusion; reserved for surgical procedures
`76`	Repeat procedure by same provider	Use when a repeated IVIG infusion is administered by the same provider on the same day
`78`	Return to OR	Not applicable to IVIG infusion
`80`	Assistant surgeon	Not applicable to IVIG infusion
`82`	Assistant surgeon (when qualified resident unavailable)	Not applicable to IVIG infusion
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery	Not applicable to IVIG infusion
`CQ`	Service furnished by a resident, not teaching physician	Use if a resident provided the infusion without attending involvement per payer rules

Taxonomy Code	Specialty	Notes
`207RH0000X`	Hematology & Oncology	Hematologists frequently manage primary immunodeficiency and coordinate IVIG therapy
`2080P0207X`	Allergy & Immunology	Allergists/immunologists commonly prescribe and oversee IVIG for immunodeficiency and autoimmune conditions
`207L00000X`	Infusion Therapy	Infusion specialists and advanced practice nurses provide IVIG administration and monitoring
`261QA1900X`	Hospitalist Medicine	Hospitalists manage inpatient IVIG infusions for acute indications
`207K00000X`	Neurology	Neurologists order IVIG for conditions such as CIDP and Guillain-Barré syndrome

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`D80.0`	Hereditary hypogammaglobulinemia	Primary immunodeficiency treated with regular IVIG replacement therapy
`D83.0`	Common variable immunodeficiency	IVIG is standard treatment to prevent infections and maintain IgG levels
`D84.9`	Immunodeficiency, unspecified	IVIG may be indicated when immunodeficiency is documented and replacement therapy is required
`G61.0`	Guillain-Barré syndrome	IVIG is a first-line immune-modulating therapy for acute GBS
`G61.81`	Chronic inflammatory demyelinating polyneuropathy (CIDP)	IVIG is an FDA-approved therapy for CIDP to improve neurologic function and slow progression
`M35.9`	Systemic involvement of connective tissue disease, unspecified	IVIG used as immunomodulatory therapy in select autoimmune connective tissue disorders
`M32.10`	Systemic lupus erythematosus, organ or system involvement unspecified	IVIG may be used in refractory or severe autoimmune manifestations as adjunctive therapy

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96413`	Chemotherapy administration, infusion technique; intravenous, up to 1 hour, single or initial drug	Often used for billing IV infusion nursing time for therapies like IVIG when payer guidance permits documenting infusion administration duration
`96415`	Each additional hour (chemotherapy/infusion)	Used to report extended infusion time beyond the initial hour when applicable to IVIG infusions requiring prolonged administration
`36415`	Collection of venous blood by venipuncture	Commonly performed prior to infusion for baseline laboratory monitoring (e.g., CMP, CBC)
`36561`	Insertion of tunneled centrally inserted central venous catheter, without subcutaneous port	Performed when long-term or repeated IVIG infusions require central access
`96360`	Intravenous infusion, hydration; initial, 31 minutes to 1 hour	Sometimes used per payer rules for non-chemotherapy infusion administration of IVIG if specific infusion codes are not accepted

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS J0120: Injection, Tetracycline, Up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS J0122: Injection, Eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS J0131: Injection Acetaminophen, 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS J0134: Injection, Acetaminophen (Fresenius Kabi), 10 mg

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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HCPCS J1576: Immune Globulin (Panzyga) IV, 500 mg

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Billing Code Overview

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HCPCS J1576: Immune Globulin (Panzyga) IV, 500 mg

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

HCPCS J1576: Immune Globulin (Panzyga) IV, 500 mg

Sign up for hcpcs J1576 policy alerts

Billing Code Overview

HCPCS J1576: Immune Globulin (Panzyga) IV, 500 mg

Sign up for hcpcs J1576 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does HCPCS code J1576 represent?

Where is J1576 typically administered and what is the usual clinical workflow?

Which CPT codes are commonly billed in conjunction with J1576 for infusion services?

What modifiers and special coding situations should be considered when billing J1576?

Which diagnoses are commonly associated with billing J1576?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What does HCPCS code J1576 represent?

Where is J1576 typically administered and what is the usual clinical workflow?

Which CPT codes are commonly billed in conjunction with J1576 for infusion services?

What modifiers and special coding situations should be considered when billing J1576?

Which diagnoses are commonly associated with billing J1576?

References