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    OpenPayerBilling CodesAplastic and other anemias and other bone marrow failure syndromesICD-10-CM d61-other-aplastic-anemias
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    ICD-10-CM Code For Other Aplastic Anemias And Other Bone Marrow Failure Syndromes: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D61 includes aplastic anemias and other bone marrow failure syndromes such as idiopathic aplastic anemia, drug-induced marrow aplasia, and other specified and unspecified marrow failure disorders that lead to decreased production of blood cells. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving pancytopenia or isolated cytopenias resulting from marrow failure, capturing severity, etiology, and treatment implications. Accurate coding within the ICD-10-CM D61 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM D61: Other Aplastic Anemias And Other Bone Marrow Failure Syndromes Overview

    This group includes diagnoses for aplastic anemias and other conditions causing bone marrow failure that impair hematopoiesis. They target the hematologic system and result in pancytopenia or isolated cytopenias with risk for infection and bleeding. Accurate coding matters for appropriate clinical documentation and impacts reimbursement and resource allocation.

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    When to Use

    Use a code from this group when clinical documentation indicates marrow failure as the cause of cytopenias, including pancytopenia or isolated anemia, neutropenia, or thrombocytopenia due to aplasia. Select the specific code that reflects documented etiology when available, such as drug-induced or other specified causes.

    ICD-10-CM Codes

    13 rows

    ICD-10-CM CodeDescription
    D61.01Constitutional (pure) red blood cell aplasia
    D61.02Shwachman-Diamond syndrome
    D61.03Fanconi anemia
    D61.09Other constitutional aplastic anemia
    D61.1Drug-induced aplastic anemia
    D61.2Aplastic anemia due to other external agents
    D61.3Idiopathic aplastic anemia
    D61.810Antineoplastic chemotherapy induced pancytopenia
    D61.811Other drug-induced pancytopenia
    D61.818Other pancytopenia
    D61.82Myelophthisis
    D61.89Other specified aplastic anemias and other bone marrow failure syndromes
    D61.9Aplastic anemia, unspecified

    DRG Codes

    12 rows

    DRG CodeDescription
    808Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC
    809Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC
    810Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC
    820Lymphoma and Leukemia with Major O.R. Procedures with MCC
    821Lymphoma and Leukemia with Major O.R. Procedures with CC
    822Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
    823Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
    824Lymphoma and Non-Acute Leukemia with Other Procedures with CC
    825Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
    840Lymphoma and Non-Acute Leukemia with MCC
    841Lymphoma and Non-Acute Leukemia with CC
    842Lymphoma and Non-Acute Leukemia without CC/MCC

    Typical Clinical Scenarios

    • An adult with recent onset fatigue, mucosal bleeding, and petechial rash presents to the emergency department after a syncopal episode. Laboratory tests reveal severe pancytopenia with markedly decreased reticulocyte count and a hypocellular bone marrow biopsy without infiltration or fibrosis, consistent with an acute bone marrow failure syndrome; an acquired aplastic process is diagnosed and urgent hematology referral is arranged. Typical codes: D61.01, D61.02
    • A middle-aged patient with a history of long-term exposure to benzene and prior chemotherapy develops progressive anemia and neutropenia over months, leading to chronic transfusion dependence and recurrent infections; marrow evaluation shows persistent hypoplasia without malignant transformation. This represents a chronic, secondary aplastic anemia related to environmental and therapeutic exposures, coded to reflect the chronic marrow failure state. Typical codes: D61.3, D61.2
    • A hospitalized patient with multi-organ failure after a severe viral infection is noted to have new-onset pancytopenia; workup attributes the cytopenias to a post-infectious marrow aplasia with ongoing sepsis complicating management. In this context the marrow failure is a complication/comorbidity of the acute infectious illness and critical care course and is coded accordingly. Typical codes: D61.09, D61.811

    Related Codes

    D60-ACQUIRED-PURE-RED-CELL-APLASIA

    ICD-10-CM Code For Acquired Pure Red Cell Aplasia Erythroblastopenia: Group Overview

    D62-ACUTE-POSTHEMORRHAGIC-ANEMIA

    ICD-10-CM Code For Acute Posthemorrhagic Anemia: Group Overview

    D63-ANEMIA-IN-CHRONIC-DISEASES

    ICD-10-CM Code For Anemia In Chronic Diseases Classified Elsewhere: Group Overview

    D64-OTHER-ANEMIAS

    ICD-10-CM Code For Other Anemias: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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