Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.30
    OpenPayerBilling CodesFluid washings, Hybridization and Sex Chromatin Identification ProceduresCPT cpt-88108-cytopathology-fluid-smear-concentration-technique
    Ask Trek AI about this page

    CPT 88108: Cytopathology Concentration Smear Preparation and Interpretation

    Medicare pays $48 on average nationally for this procedure.

    CPT code 88108 describes cytopathology service in which an analyst prepares and interprets smears from non-cervical/non-vaginal fluids, washings, or brushings using a concentration technique; service type is cytopathology specimen preparation and interpretation, typically performed in a clinical laboratory or pathology department from body fluid or brushing samples.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

    Customize your policy alerts

    Sign up for cpt 88108 policy alerts

    Get alerted when payer policies referencing 88108 are released or updated.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • Facility ComparisonBeds, revenue & payer mix
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to the hospital with progressive shortness of breath and a moderate pleural effusion identified on chest radiograph. Thoracentesis is performed and pleural fluid is submitted to the pathology laboratory. A cytotechnologist or cytology analyst prepares concentrated smears using a concentration technique (for example, cytocentrifugation or cytospin) to concentrate cells from the pleural fluid, excluding cervical or vaginal specimens, and performs microscopic interpretation for cellular abnormalities, infection, inflammation, or malignancy. The workflow typically includes accessioning the specimen, preparing concentrated smears, staining (Diff-Quik, Papanicolaou), microscopic review by the analyst, documentation of findings, and communication of critical or suspicious results to the ordering clinician. Final diagnosis or report may involve reflex ancillary testing (immunocytochemistry, flow cytometry, or molecular testing) if indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88112Cytopathology, cervical or vaginal (any reporting method), requiring interpretation by a physician, automated screening may be includedNot used for non-gynecologic fluids; distinguishes gynecologic Pap testing from fluid concentration techniques
    88185Cytopathology, review of fine needle aspirate (FNA) smears by a pathologist; preparation and interpretationRelated when an FNA is performed on a mass in conjunction with pleural or peritoneal fluid cytology
    88342Immunohistochemistry, per single antigen; used when immunostains are performed on cytology cell block preparationsAncillary test commonly performed after initial 88108 interpretation when immunophenotyping is needed
    88182Cytopathology, thin layer preparation, non-gyn, interpretation by a physicianAlternative non-concentration preparation technique for non-gynecologic specimens
    88104Cytopathology, cervical or vaginal (Pelvic) smear interpretation by physicianIncluded to contrast gynecologic cytology coding; not billed with 88108 which excludes cervical or vaginal fluids

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    367A00000X
    3418M1120X
    225XG0600X
    2278P1004X
    225B00000X
    170300000X
    207QS1201X

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-88104-CYTOPATHOLOGY-SMEAR-PREP-AND-INTERPRETATION

    CPT 88104: Cytopathology Smear Preparation and Interpretation

    CPT-88106-NON-GYNECOLOGIC-CYTOPATHOLOGY-SMEAR-SIMPLE-FILTER

    CPT 88106: Cytopathology Smear of Non-Cervical Fluids

    CPT-88112-LIQUID-BASED-CYTOPATHOLOGY-SELECTIVE-CELLULAR-ENHANCEMENT

    CPT 88112: Selective Cellular Enhancement for Cytopathology

    CPT-88120-URINARY-TRACT-IN-SITU-HYBRIDIZATION-MORPHOMETRIC-ANALYSIS

    CPT 88120: In Situ Hybridization on Urinary Tract Specimen, 3–5 Probes

    CPT-88121-URINARY-TRACT-IN-SITU-HYBRIDIZATION-MORPHOMETRY

    CPT 88121: Urine In Situ Hybridization with 3–5 Probes

    CPT-88125-FORENSIC-CYTOPATHOLOGY-TECHNICAL-SERVICE

    CPT 88125: Cytopathology Specimen Analysis for Forensic Testing

    CPT-88130-SEX-CHROMATIN-BARR-BODY-ANALYSIS

    CPT 88130: Sex Chromatin (Barr Body) Analysis

    CPT-88140-PERIPHERAL-BLOOD-SMEAR-SEX-CHROMATIN-IDENTIFICATION

    CPT 88140: Peripheral Blood Smear for Sex Chromatin Identification

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.