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    OpenPayerBilling CodesFluid washings, Hybridization and Sex Chromatin Identification ProceduresCPT cpt-88106-non-gynecologic-cytopathology-smear-simple-filter
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    CPT 88106: Cytopathology Smear of Non-Cervical Fluids

    Medicare pays $47 on average nationally for this procedure.

    CPT code 88106 describes the preparation and interpretation of smears from non-cervical or non-vaginal cytopathology fluids, washings, or brushings using a simple filter method; this is a cytopathology procedure performed by an analyst (pathologist or cytotechnologist) and represents a diagnostic cytology interpretation service, typically provided in a pathology or cytology laboratory setting or hospital lab where fluid or brushing specimens are processed and examined.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to a hospital outpatient laboratory after a thoracentesis for pleural effusion associated with suspected malignancy. The interventionalist collects pleural fluid and sends a portion to the cytology laboratory. A cytotechnologist or cytopathology analyst prepares smears of the fluid using a simple filter (non-cervical) method, examines the cellular material microscopically, and issues an interpretation for the clinician. The service typically occurs in the hospital laboratory, an independent pathology/cytology lab, or an outpatient surgical center. Common clinical workflow steps: sample receipt and accessioning, preparation of filter smears, microscopic review and interpretation, documentation in the laboratory information system, and communication of results to the ordering provider for correlation with radiology and clinical findings.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88102Cytopathology, smears, cervical or vaginal (Papanicolaou test), screeningAlternative cytology smear code for cervical/vaginal samples; distinguishes cervical/vaginal from non-cervical fluids.
    88104Cytopathology, fluid, washings, or brushings, except cervical or vaginal, requiring interpretation by physician (direct smears)Covers cytology preparations that may be more extensive or use different methods than the simple filter method in 88106; used for comparable non-cervical specimens.
    88108Cytopathology, fluid, washings, or brushings, except cervical or vaginal; each additional fluid/ specimenUsed when multiple separate non-cervical fluid specimens require individual cytologic interpretation in the same encounter.
    88112Cytopathology, immunocytochemistry, per specimenAncillary immunocytochemical studies that may be performed on cell blocks or smears after initial review of 88106 preparations.
    88305Surgical pathology, gross and microscopic examination, intermediate complexityPerformed when cytology suggests a need for tissue biopsy and histopathologic correlation; commonly follows cytology findings prompting tissue diagnosis.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207R00000X
    207K00000X
    208000000X
    208D00000X
    363L00000X
    261QE0800X
    207VE0102X
    2084B0040X

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-88104-CYTOPATHOLOGY-SMEAR-PREP-AND-INTERPRETATION

    CPT 88104: Cytopathology Smear Preparation and Interpretation

    CPT-88108-CYTOPATHOLOGY-FLUID-SMEAR-CONCENTRATION-TECHNIQUE

    CPT 88108: Cytopathology Concentration Smear Preparation and Interpretation

    CPT-88112-LIQUID-BASED-CYTOPATHOLOGY-SELECTIVE-CELLULAR-ENHANCEMENT

    CPT 88112: Selective Cellular Enhancement for Cytopathology

    CPT-88120-URINARY-TRACT-IN-SITU-HYBRIDIZATION-MORPHOMETRIC-ANALYSIS

    CPT 88120: In Situ Hybridization on Urinary Tract Specimen, 3–5 Probes

    CPT-88121-URINARY-TRACT-IN-SITU-HYBRIDIZATION-MORPHOMETRY

    CPT 88121: Urine In Situ Hybridization with 3–5 Probes

    CPT-88125-FORENSIC-CYTOPATHOLOGY-TECHNICAL-SERVICE

    CPT 88125: Cytopathology Specimen Analysis for Forensic Testing

    CPT-88130-SEX-CHROMATIN-BARR-BODY-ANALYSIS

    CPT 88130: Sex Chromatin (Barr Body) Analysis

    CPT-88140-PERIPHERAL-BLOOD-SMEAR-SEX-CHROMATIN-IDENTIFICATION

    CPT 88140: Peripheral Blood Smear for Sex Chromatin Identification

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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