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    v1.0.30
    OpenPayerBilling CodesInfectious Agent Antigen DetectionCPT cpt-87623-hpv-low-risk-nucleic-acid-detection
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    CPT 87623: HPV Low‑Risk Nucleic Acid Detection

    CPT code 87623 describes a laboratory nucleic acid detection test for human papillomavirus (HPV) low‑risk types (for example, types 6, 11, 42, 43, and 44), performed by a lab analyst to identify viral genetic material; service type: molecular diagnostic infectious disease testing; typical site of service: clinical laboratory or hospital laboratory where specimens are processed for HPV nucleic acid testing.

    For related coverage guidance, see recent payer policy updates: Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatment, HIV/AIDS Pharmacologic Prevention and Treatment, Long-Acting Injectable Antiretroviral Agents for HIV.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old female presents to a gynecology clinic for evaluation of genital warts and follow-up after abnormal cervical cytology. The clinician performs a genital examination and collects a specimen (swab or tissue) appropriate for nucleic acid testing. The specimen is sent to the clinical laboratory where a molecular analyst performs an HPV nucleic acid detection assay specifically targeting low-risk HPV types such as 6, 11, 42, 43, and 44 (CPT 87623). Results are used to confirm presence of low-risk HPV strains associated with condyloma acuminata or to guide counseling and topical or procedural treatment decisions. Typical workflow: office visit and specimen collection by an OB/GYN, family medicine, or dermatology clinician; specimen transport to a reference or hospital laboratory; laboratory processing and reporting by a molecular diagnostics technologist; final report routed back to ordering clinician for follow-up.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87623Infectious agent detection by nucleic acid (DNA or RNA); HPV, low-risk types (e.g., 6,11,42,43,44)Primary laboratory test for detecting low-risk HPV types.
    87210Smear, primary source with interpretation; microbial direct smear and/or wet mount for infectious agentsMay be performed at point of care to evaluate visible genital lesions prior to or concurrent with molecular testing.
    88142Cytopathology, cervical or vaginal; cytologic preparation with manual screening under a rapid prep methodCervical cytology often ordered alongside HPV testing for evaluation of abnormal Pap results.
    87621Infectious agent detection by nucleic acid (DNA or RNA); HPV, high-risk types, e.g., 16,18,31,33,35Performed when high-risk oncogenic HPV screening is indicated; complements low-risk testing when clinical suspicion includes oncogenic strains.
    88174Cervical or vaginal cytology with HPV testing (automated) — reflex or co-testing codes vary by payerOften part of co-testing strategies where cytology and HPV testing are combined in cervical screening workflows.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    207Q00000X
    207N00000X
    363A00000X
    207L00000X
    208VP0000X
    2084N0008X
    2081H0002X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A63.0Anogenital (venereal) warts
    B97.7Papillomavirus as the cause of diseases classified elsewhere
    D06.9Carcinoma in situ of cervix, unspecified
    D07.0Carcinoma in situ of endometrium
    N48.89Other specified disorders of penis
    N76.0Acute vaginitis
    N76.1Subacute and chronic vaginitis
    N76.2Acute vulvitis
    N87.0Mild cervical dysplasia
    N87.1Moderate cervical dysplasia

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    HIV/AIDS Pharmacologic Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01

    Related Codes

    CPT-87260-ADENOVIRUS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

    CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87265: Bordetella Antigen Detection by Immunofluorescence

    CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

    CPT 87267: Enterovirus Antigen Detection by DFA

    CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87269: Giardia Antigen Detection by Immunofluorescence

    CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

    CPT-87271-CMV-DFA-ANTIGEN-DETECTION

    CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

    CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

    CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

    CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

    CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87275: Influenza B Antigen Detection by Immunofluorescence

    Showing 1–10 of 167

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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