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    v1.0.28
    OpenPayerBilling CodesInfectious Agent Antigen DetectionCPT cpt-87502-multiplex-influenza-nucleic-acid-detection-2-subtypes
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    CPT 87502: Multiplex Influenza Nucleic Acid Detection, 2 Targets

    Commercial payers pay $170 on average nationally for this procedure.

    CPT code 87502 describes a laboratory nucleic acid detection test using multiplex amplified probe technique (with or without multiplex reverse transcription) to identify the presence of multiple influenza virus types or subtypes and is reported for the first two types or subtypes; this is a molecular diagnostic service typically performed in a clinical laboratory or pathology setting for respiratory infection evaluation.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    National Reimbursement Benchmarks

    National commercial reimbursement for CPT 87502 centers around BUCA’s average commercial rate of $170.10, which serves as a midpoint against a wide spectrum among major payers. Blue Cross Blue Shield carries one of the highest central tendencies with a median of $216.20 and a mean of $221.60, while Cigna and Aetna sit lower with medians near $92.70 and $95.80 respectively. UnitedHealth Group’s median of $57.50 and mean of $78.70 place it toward the lower end of the scale, illustrating meaningful variation across carriers.

    Dispersion measured by the interquartile range (P75–P25) highlights differences in contract variability: Blue Cross Blue Shield has a tight IQR of $30.30 ($232.20–$201.90), indicating relatively concentrated rates, whereas Aetna’s IQR is $66.10 ($143.70–$76.60) and Cigna’s is $70.90 ($130.90–$60.00), both showing broader spread. UnitedHealth Group’s IQR of $57.60 ($95.80–$40.20) sits between these, signaling moderate variability compared with BUCA’s commercial quartiles ($185.60–$140.60 gives an IQR of $45.00).

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old adult presents to a primary care clinic in mid-winter with 3 days of fever, cough, myalgias, sore throat, and nasal congestion. The clinician documents influenza-like illness and collects a nasopharyngeal swab for molecular testing. The specimen is sent to the outpatient clinical laboratory or hospital molecular lab. The laboratory performs nucleic acid amplification with multiplex amplified probe technique (and reverse transcription as required) to detect and differentiate two influenza virus types/subtypes. Results are reported to the ordering Family Medicine physician and uploaded to the electronic health record for treatment decisions, antiviral prescribing, and public health reporting if a novel strain is identified. Typical workflow steps: specimen collection in clinic or ED, accessioning in lab, multiplex nucleic acid extraction and amplification, result validation by lab personnel, and transmission of results to the ordering provider and public health as indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87400Infectious agent antigen detection by enzyme immunoassay technique, qualitative or semiquantitative; influenza virus, direct or indirect immunofluorescent antibody stainingAlternative antigen-based influenza testing method; may be performed in point-of-care settings prior to or instead of molecular testing

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    291U00000XClinical Medical Laboratory(1) A clinical laboratory is a facility for the biological, microbiological, serological, chemical, immunohematological, hematological, biophysical, c…
    207ZP0102XAnatomic Pathology & Clinical Pathology PhysicianA pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    2251H1200XHand Physical TherapistRespiratory, Developmental, Rehabilitative and Restorative Service Providers · Physical Therapist
    247ZC0005XClinical Laboratory Director (Non-physician)An individual who is state-licensed as a clinical laboratory director and meets the qualifications in the Clinical Laboratory Improvement Amendments o…
    364SC0200XCritical Care Medicine Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    225XL0004XLow Vision Occupational TherapistOccupational therapists enable children and adults with visual impairment to engage in their chosen daily living activities safely and as independentl…
    246XS1301XSonography Specialist/Technologist CardiovascularA cardiovascular sonography technologist operates special equipment to create images and conduct tests of the cardiovascular system. They work with ph…

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV)blue cross blue shield - louisiana2026-09-15

    Related Codes

    CPT-87260-ADENOVIRUS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

    CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87265: Bordetella Antigen Detection by Immunofluorescence

    CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

    CPT 87267: Enterovirus Antigen Detection by DFA

    CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87269: Giardia Antigen Detection by Immunofluorescence

    CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

    CPT-87271-CMV-DFA-ANTIGEN-DETECTION

    CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

    CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

    CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

    CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

    CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87275: Influenza B Antigen Detection by Immunofluorescence

    Showing 1–10 of 167

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

    87804
    Infectious agent antigen detection by immunoassay with direct optical observation; influenza
    Rapid antigen test option commonly used in clinics or EDs; may be used as an initial screen before ordering molecular test 87502
    87631Infectious agent detection by nucleic acid (DNA or RNA); respiratory virus, multiplex reverse transcription and amplified probe technique, multiple types or subtypes, 3-5 targetsLarger-panel multiplex molecular test covering additional respiratory viruses; used when broader pathogen coverage is clinically indicated beyond the two-target scope of 87502
    87632Infectious agent detection by nucleic acid (DNA or RNA); respiratory virus, multiplex reverse transcription and amplified probe technique, multiple types or subtypes, 6-11 targetsExpanded respiratory pathogen panel often used when differential diagnosis includes multiple viral targets; may be ordered instead of or in addition to 87502 depending on clinical need