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    v1.0.28
    OpenPayerBilling CodesInfectious Agent Antigen DetectionCPT cpt-87484-ehrlichia-chaffeensis-nucleic-acid-test
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    CPT 87484: Ehrlichia chaffeensis Nucleic Acid Amplification Test

    CPT code 87484 describes a nucleic acid amplification test using an amplified probe technique to detect DNA or RNA from the bacterium Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis (HME); service type: infectious disease molecular diagnostic testing using amplified probe nucleic acid detection; typical site of service: outpatient laboratory or hospital laboratory performing molecular diagnostics.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient presents to an urgent care clinic in late spring with 5 days of fever, headache, malaise, myalgias, and a history of a recent tick bite while hiking. The clinician performs an evaluation for tick-borne illnesses and orders nucleic acid amplification testing for Ehrlichia chaffeensis using an amplified probe technique (87484). A single peripheral blood specimen is collected and sent to an affiliated molecular diagnostics laboratory. The laboratory performs the amplified probe assay and returns a result used by the clinician to confirm or exclude human monocytic ehrlichiosis (HME). Typical site of service includes outpatient clinics, urgent care centers, emergency departments, and specialized infectious disease or hospital laboratories. The clinical workflow: patient evaluation → specimen collection (blood) → courier to lab → molecular amplified probe testing (87484) → result reporting and clinician-directed treatment decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureTypical specimen collection performed prior to molecular testing for 87484.
    80061Lipid panel (example of routine chemistry panels)Common concurrent laboratory tests ordered during acute illness evaluation in outpatient or ED settings.
    87535Infectious agent detection by nucleic acid (e.g., Babesia)Other tick-borne pathogen molecular tests that may be ordered alongside 87484 to evaluate febrile patients with tick exposure.
    87476Detection of Borrelia burgdorferi (Lyme) amplified probeMolecular testing for other tick-borne organisms often considered in the differential diagnosis.
    86580Skin or wound allergen testing (example service)Ancillary laboratory services occasionally performed but not commonly directly related; included to represent other lab workflows.
    G0480Drug testing, presumptive (not specific to this procedure)Represents additional laboratory testing that may be performed in the acute evaluation workflow.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    146E00000XCommunity ParamedicA Community Paramedic is trained in responding to a scene and arranging appointments and transportation to alternate destinations through established …
    320800000XMental Illness Community Based Residential Treatment FacilityA home-like residential facility providing psychiatric treatment and psycho/social rehabilitative services to individuals diagnosed with mental illnes…
    207RI0011XInterventional Cardiology PhysicianAn area of medicine within the subspecialty of cardiology, which uses specialized imaging and other diagnostic techniques to evaluate blood flow and p…

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    A69.20Lyme disease, unspecified
    A69.21Meningitis due to Lyme disease
    A77.0Spotted fever due to Rickettsia rickettsii
    A77.8Other spotted fevers
    A77.9Spotted fever, unspecified
    A92.9Mosquito-borne viral fever, unspecified
    B34.9Viral infection, unspecified
    B37.9Candidiasis, unspecified
    J02.9Acute pharyngitis, unspecified
    J06.9Acute upper respiratory infection, unspecified

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    9 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-87260-ADENOVIRUS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

    CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87265: Bordetella Antigen Detection by Immunofluorescence

    CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

    CPT 87267: Enterovirus Antigen Detection by DFA

    CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87269: Giardia Antigen Detection by Immunofluorescence

    CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

    CPT-87271-CMV-DFA-ANTIGEN-DETECTION

    CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

    CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

    CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

    CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

    CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87275: Influenza B Antigen Detection by Immunofluorescence

    Showing 1–10 of 167

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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