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    OpenPayerBilling CodesInfectious Agent Antigen DetectionCPT cpt-87283-measles-rubeola-antigen-detection-immunofluorescence
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    CPT 87283: Measles (Rubeola) Antigen Detection by Immunofluorescence

    CPT code 87283 describes a laboratory procedure for detection of Rubeola (Measles virus, MeV) antigens using immunofluorescent antibody staining with fluorescence microscopy; this is a virology antigen detection test typically performed as a specialty laboratory diagnostic service in hospital or reference laboratory settings and is used when direct identification of measles viral antigen in clinical specimens is required.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric outpatient infectious disease clinic evaluates a 2-year-old child presenting with fever, cough, conjunctivitis, and a maculopapular rash after recent exposure to a household contact with confirmed measles. The clinician orders laboratory confirmation to detect measles virus antigen from a nasopharyngeal swab. A medical laboratory technologist or lab analyst in a hospital or public health laboratory performs an immunofluorescent antibody stain followed by fluorescence microscopy to detect rubeola (Measles virus) antigen. Specimen collection, accessioning, staining, microscopic analysis, and documentation of results occur under the laboratory’s standard operating procedures. Results are reported to the ordering clinician and to public health authorities per local reporting regulations.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87283Infectious agent antigen detection by immunofluorescent stain; rubeola (measles) virusPrimary procedure: detection of measles virus antigen by immunofluorescence and fluorescence microscopy.
    87252Infectious agent antigen detection by immunofluorescent stain; respiratory syncytial virus (RSV)Alternative or additional rapid antigen immunofluorescence test when viral respiratory panel is needed.
    87661Infectious agent detection by nucleic acid (DNA or RNA); respiratory syncytial virus, amplified probe techniqueMolecular testing that may be ordered alongside or following antigen testing for higher sensitivity.
    87430Infectious agent antigen detection by immunoassay, direct; streptococcus, group A (e.g., rapid strep)Example of other point-of-care antigen tests performed in clinical workflow for differential diagnosis of febrile rash illness.
    87804Infectious agent antigen detection by immunoassay for multiple viruses (e.g., influenza A/B, RSV)Panel antigen testing that may be performed in parallel when assessing viral respiratory infections.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    152WS0006XSports Vision OptometristAn optometrist who offers services designed to care for unique vision care needs of athletes, which may include one of more of the following services:…
    2251G0304XGeriatric Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Geriatric Physical Therapy, who has d…
    311Z00000XCustodial Care FacilityA facility providing care that serves to assist an individual in the activities of daily living, such as assistance in walking, getting in and out of …
    208VP0014XInterventional Pain Medicine PhysicianInterventional Pain Medicine is the discipline of medicine devoted to the diagnosis and treatment of pain and related disorders principally with the a…
    172V00000XCommunity Health WorkerCommunity health workers (CHW) are lay members of communities who work either for pay or as volunteers in association with the local health care syste…
    103GC0700XDeactivated - Clinical Neuropsychologist

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV)blue cross blue shield - louisiana2026-09-15

    Related Codes

    CPT-87260-ADENOVIRUS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87260: Adenovirus Antigen Detection by Immunofluorescence

    CPT-87265-BORDETELLA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87265: Bordetella Antigen Detection by Immunofluorescence

    CPT-87267-ENTEROVIRUS-DFA-ANTIGEN-DETECTION

    CPT 87267: Enterovirus Antigen Detection by DFA

    CPT-87269-GIARDIA-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87269: Giardia Antigen Detection by Immunofluorescence

    CPT-87270-CHLAMYDIA-TRACHOMATIS-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87270: Chlamydia trachomatis Antigen Detection by Immunofluorescence

    CPT-87271-CMV-DFA-ANTIGEN-DETECTION

    CPT 87271: CMV Antigen Detection by Direct Fluorescent Antibody

    CPT-87272-CRYPTOSPORIDIUM-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87272: Cryptosporidium Antigen Immunofluorescent Test

    CPT-87273-HSV-2-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87273: HSV-2 Antigen Detection by Immunofluorescence

    CPT-87274-HSV-1-ANTIGEN-IMMUNOFLUORESCENCE

    CPT 87274: HSV-1 Antigen Detection by Immunofluorescence

    CPT-87275-INFLUENZA-B-IMMUNOFLUORESCENT-ANTIGEN-DETECTION

    CPT 87275: Influenza B Antigen Detection by Immunofluorescence

    Showing 1–10 of 167

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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