CPT code 86701 represents an immunoassay performed on patient serum to detect antibodies to human immunodeficiency virus 1 (HIV-1). As a commonly ordered serologic test in diagnostic and screening pathways for suspected or confirmed HIV exposure, this laboratory procedure is a staple in both outpatient and inpatient care. Nationally, accurate coding and consistent coverage policy for antibody testing affect clinical workflows, public health reporting, and laboratory reimbursement.

Major national payers included in this analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of payer coverage patterns, typical sites of service and clinical context for ordering, and comparisons to related hepatitis and hepatic function laboratory studies. The publication summarizes common billing and administrative considerations, lists relevant clinical scenarios tied to common ICD-10 diagnoses, and maps closely related laboratory CPT codes for clinicians and coding professionals.

This briefing is intended to give laboratory directors, billing staff, and clinician leaders a concise reference on the clinical purpose of CPT code 86701, the payer landscape, and how this test fits with adjacent laboratory services used in evaluating infectious and hepatic presentations.