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    v1.0.28
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86367-cd34-stem-cell-count-lab
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    CPT 86367: CD34+ Stem Cell Enumeration

    CPT code 86367 describes a laboratory test performed to quantify CD34-positive hematopoietic stem/progenitor cells in a patient specimen, typically a peripheral blood sample, using flow cytometry or other appropriate cell-counting methods; the service is a laboratory diagnostic test usually provided in a clinical laboratory or hospital laboratory setting and used to assess stem cell mobilization or availability for transplantation or cellular therapies.

    For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old male with relapsed acute myeloid leukemia is undergoing evaluation for autologous hematopoietic stem cell collection. Peripheral blood is sampled following mobilization with granulocyte colony-stimulating factor. The laboratory performs a flow cytometry-based enumeration to count total CD34+ hematopoietic progenitor cells in the specimen to determine adequacy for collection and to time apheresis. Results guide the clinical team on whether to proceed with apheresis, repeat mobilization, or administer plerixafor. Typical workflow: order placed by hematology/oncology; phlebotomy collects peripheral blood into appropriate anticoagulant tubes; specimen transported to the clinical laboratory; technologist performs flow cytometric staining for CD34 and viable cell gating; analyst runs acquisition, counts CD34+ events, calculates cells/µL and total yield estimates; report released to ordering provider. Typical site of service: hospital-based outpatient oncology infusion center, ambulatory phlebotomy lab, or hospital clinical laboratory.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86367Immunohematology and blood banking procedure; CD34 (stem cell) countPrimary procedure: enumeration of CD34+ stem cells in a patient specimen.
    86356Immunohematology and blood banking; CD34 enumeration by flow cytometry (alternate code)Alternative coding sometimes used for CD34 testing depending on payer or technique; relates as an alternate method of enumeration.
    88184Flow cytometry, cell surface markers, per specimen; single platform absolute countPerformed when flow cytometric absolute counting methods are used to quantify CD34+ cells; technically related to 86367 when platform-specific code applies.
    36415Collection of venous blood by venipuncturePreceding procedure: blood draw required to obtain specimen for CD34 testing.
    36514Insertion of non-tunneled centrally inserted catheter for apheresisPerformed when central venous access is required for stem cell apheresis following adequate CD34 counts.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    2080P0207XPediatric Hematology & Oncology PhysicianA pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
    207QA0401XAddiction Medicine (Family Medicine) PhysicianA family medicine physician who specializes in the diagnosis and treatment of addictions.
    163WH1000XHospice Registered NurseNursing Service Providers · Registered Nurse
    261QR1300XRural Health Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    204E00000XOral & Maxillofacial Surgery (D.M.D.)Oral and maxillofacial surgeons are trained to recognize and treat a wide spectrum of diseases, injuries and defects in the head, neck, face, jaws and…
    163WP0200XPediatric Registered NurseNursing Service Providers · Registered Nurse
    363LS0200XSchool Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C91.10Chronic lymphocytic leukemia of B-cell type not having achieved remission
    C92.00Acute myeloblastic leukemia, not having achieved remission
    C92.10Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
    C95.00Acute leukemia of unspecified cell type not having achieved remission
    C95.10Chronic leukemia of unspecified cell type not having achieved remission
    D47.9Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified
    D61.01Constitutional (pure) red blood cell aplasia
    D61.02Shwachman-Diamond syndrome
    D61.9Aplastic anemia, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    9 rows

    PolicyPayerEffective Date
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01
    Allergy Testinguniverahealthcare2026-07-16
    Omalizumab (Xolair) and related biologics coverageMass General Brigham Health Plan2026-07-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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