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    v1.0.30
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86036-antineutrophil-cytoplasmic-antibody-analyis
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    CPT 86036: Antineutrophil Cytoplasmic Antibody (ANCA) Immunoassay

    CPT code 86036 describes an immunoassay test to detect antineutrophil cytoplasmic antibodies (ANCA), reporting patterns such as pANCA or cANCA; this laboratory immunoassay service is used to help distinguish among autoimmune vasculitides and related disorders, typically performed on serum or plasma in a clinical laboratory or hospital laboratory setting.

    For related coverage guidance, see recent payer policy updates: Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policy, Allergy Testing and Injections, Allergy Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient with new-onset systemic symptoms of fatigue, low-grade fever, and unexplained weight loss presents to rheumatology after routine labs show an elevated erythrocyte sedimentation rate and persistent hematuria on urinalysis. The clinician suspects a small-vessel vasculitis such as granulomatosis with polyangiitis or microscopic polyangiitis and orders serologic testing including 86036 (antineutrophil cytoplasmic antibody, ANCA) to detect pANCA or cANCA patterns. A phlebotomy is performed in an outpatient clinic or hospital laboratory; serum is sent to the clinical immunology lab where a fluorescence immunoassay is used to detect ANCA titers and patterns. Results are interpreted by a laboratory director and reported to the ordering provider to guide further diagnostic workup (e.g., imaging, tissue biopsy) and treatment planning (e.g., immunosuppressive therapy). Typical sites of service include outpatient physician offices, hospital outpatient laboratories, and independent reference laboratories. Common patient scenarios include evaluation of suspected systemic vasculitis, workup of unexplained renal involvement with hematuria/proteinuria, assessment of autoimmune disease flares, or differentiation among autoimmune syndromes presenting with pulmonary and renal manifestations.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80053Comprehensive metabolic panelRoutine chemistry panel often ordered concurrently to assess renal function when ANCA-associated vasculitis is suspected
    85025Complete blood count (CBC) with automated differentialOrdered alongside to evaluate for anemia, leukocytosis, or other hematologic abnormalities that accompany systemic inflammation
    83970Drug assay, qualitative; immunoassaySometimes ordered in parallel when medication effects or toxicities need exclusion during diagnostic workup
    88305Surgical pathology, gross and microscopic examinationIf tissue biopsy (e.g., renal or nasal biopsy) is obtained to confirm vasculitis, pathology reporting is billed separately
    86769Antibody; tissue transglutaminase, IgA (example immunology panel code)Represents additional immunology tests that may be ordered in autoimmune workups alongside ANCA testing

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207K00000X
    2080P0206X
    174400000X
    1710I1002X
    193400000X
    302R00000X
    261QC1500X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    D86.9Sarcoidosis, unspecified
    E06.3Autoimmune thyroiditis
    I77.6Arteritis, unspecified
    J84.10Pulmonary fibrosis, unspecified
    K83.1Obstruction of bile duct
    L40.54Psoriatic juvenile arthropathy
    M05.79Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement
    M06.9Rheumatoid arthritis, unspecified
    M13.0Polyarthritis, unspecified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    10 rows

    PolicyPayerEffective Date
    Allergy Testing, Including Selected Blood, Serum and Cellular Testing and Toxicity Testing Corporate Medical Policybcbsvermont2026-11-01
    Allergy Testing and InjectionsUnitedHealthcare2026-10-01
    Allergy TestingProvidence Health Plan2026-10-01
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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