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    v1.0.28
    OpenPayerBilling CodesQualitative or Semiquantitative ImmunoassaysCPT cpt-86756-serum-immunoassay-respiratory-syncytial-virus-rsv
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    CPT 86756: Respiratory Syncytial Virus (RSV) Immunoassay, Serum

    CPT code 86756 describes a laboratory immunoassay performed by a lab analyst to detect respiratory syncytial virus (RSV) antigen in a patient’s serum; this is a diagnostic laboratory service typically billed as a pathology/clinical laboratory test and usually performed in an outpatient laboratory or hospital laboratory setting.

    For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

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    Table of contents

    Progress1 / 7

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A 9-month-old infant presents to the pediatric urgent care clinic in winter with a 3-day history of cough, nasal congestion, wheezing and increased work of breathing. The clinician performs a focused respiratory exam and documents hypoxemia by pulse oximetry and increased respiratory effort. A nasopharyngeal swab or serum sample is collected and sent to the hospital laboratory where a medical technologist performs an immunoassay to detect respiratory syncytial virus (RSV). Results are reported to the ordering clinician to guide cohorting, infection control, and supportive care decisions such as supplemental oxygen, nebulized bronchodilators, or admission for monitoring. Typical workflow: specimen collection at point of care, transport to the clinical laboratory, accessioning, performance of the immunoassay by the lab analyst, quality control review, result verification by a licensed provider or laboratory director, and electronic reporting into the patient’s record and to infection control as needed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87804Infectious agent antigen detection by immunoassay with direct optical observation; respiratory syncytial virus (RSV)Alternate rapid antigen detection method for RSV from respiratory specimens; may be performed at point of care or laboratory and used instead of or prior to serum immunoassay
    87420Infectious agent detection by nucleic acid (DNA or RNA); RSV, amplified probe techniqueMolecular RSV testing (PCR) with higher sensitivity; commonly ordered when definitive diagnosis is required or when immunoassay is negative but clinical suspicion remains
    87449Infectious agent detection by nucleic acid; respiratory viral panel, multiplexMultiplex molecular panel that includes RSV among other respiratory viruses; ordered when broader viral testing is clinically indicated
    87070Culture, bacterial; any source, screening only, with isolation and presumptive identification of isolatesLess commonly used for viral detection but may be performed for bacterial co-infection evaluation in respiratory illness
    87400Infectious agent detection by nucleic acid; influenza A and B, amplified probe techniqueInfluenza testing often performed alongside RSV testing during respiratory season to differentiate pathogens

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    174400000XSpecialistAn individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
    103TH0100XHealth Service PsychologistA psychologist, certified/licensed at the independent practice level in his/her state, who is duly trained and experienced in the delivery of direct, …
    2472V0600XVeterinary TechnicianNone
    2082S0105XSurgery of the Hand (Plastic Surgery) PhysicianA plastic surgeon with additional training in the investigation, preservation, and restoration by medical, surgical and rehabilitative means of all st…
    163WX0106XOccupational Health Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    B97.4Respiratory syncytial virus as the cause of diseases classified elsewhere
    B97.89Other viral agents as the cause of diseases classified elsewhere
    J00Acute nasopharyngitis [common cold]
    J02.9Acute pharyngitis, unspecified
    J06.9Acute upper respiratory infection, unspecified
    J10.1Influenza due to other identified influenza virus with other respiratory manifestations
    J11.1Influenza due to unidentified influenza virus with other respiratory manifestations
    J12.1Respiratory syncytial virus pneumonia
    J15.9Unspecified bacterial pneumonia
    J18.9Pneumonia, unspecified organism

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Allergy/Clinical Immunology1 / 3

    9 rows

    PolicyPayerEffective Date
    Diagnosis of Idiopathic Environmental IntoleranceOscar Health2026-10-01
    Allergen Testingblue cross blue shield - louisiana2026-09-15
    Allergen TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Hereditary Angioedema - EkterlyCigna2026-08-15
    Omalizumab products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab Products (Xolair, Omlyclo) coveragePremera Bluecross2026-08-01
    Omalizumab ProductsPremera Bluecross2026-08-01
    Allergy Testinguniverahealthcare2026-07-16
    Omalizumab (Xolair) and related biologics coverageMass General Brigham Health Plan2026-07-01

    Related Codes

    86803-QUALITATIVE-OR-SEMIQUANTITATIVE-IMMUNOASSAYS-HEPATITIS-C

    CPT 86803: Hepatitis C Antibody Immunoassay in Serum

    CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

    CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

    CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

    CPT 86001: Allergen-Specific IgG Assay, Technical Component

    CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

    CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

    CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

    CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

    CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

    CPT 86008: Allergen Component–Specific IgE Assay

    CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

    CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

    CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

    CPT 86021: Leukocyte Antibody Identification Laboratory Test

    CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

    CPT 86022: Platelet Antibody Detection and Identification

    CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

    CPT 86023: Platelet-Associated Immunoglobulin Assay

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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